ID A0A2H3I8E5_FUSOX Unreviewed; 857 AA.
AC A0A2H3I8E5;
DT 31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT 31-JAN-2018, sequence version 1.
DT 22-FEB-2023, entry version 14.
DE RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN ORFNames=AU210_001315 {ECO:0000313|EMBL:PCD45889.1};
OS Fusarium oxysporum f. sp. radicis-cucumerinum.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium;
OC Fusarium oxysporum species complex.
OX NCBI_TaxID=327505 {ECO:0000313|EMBL:PCD45889.1, ECO:0000313|Proteomes:UP000219602};
RN [1] {ECO:0000313|EMBL:PCD45889.1, ECO:0000313|Proteomes:UP000219602}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Forc016 {ECO:0000313|EMBL:PCD45889.1,
RC ECO:0000313|Proteomes:UP000219602};
RX PubMed=27387256; DOI=10.1111/1462-2920.13445;
RA van Dam P., Fokkens L., Schmidt S.M., Linmans J.H., Kistler H.C., Ma L.J.,
RA Rep M.;
RT "Effector profiles distinguish formae speciales of Fusarium oxysporum.";
RL Environ. Microbiol. 18:4087-4102(2016).
RN [2] {ECO:0000313|EMBL:PCD45889.1, ECO:0000313|Proteomes:UP000219602}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Forc016 {ECO:0000313|EMBL:PCD45889.1,
RC ECO:0000313|Proteomes:UP000219602};
RX PubMed=28831051; DOI=10.1038/s41598-017-07995-y;
RA van Dam P., Fokkens L., Ayukawa Y., van der Gragt M., Ter Horst A.,
RA Brankovics B., Houterman P.M., Arie T., Rep M.;
RT "A mobile pathogenicity chromosome in Fusarium oxysporum for infection of
RT multiple cucurbit species.";
RL Sci. Rep. 7:9042-9042(2017).
CC -!- FUNCTION: Essential component of the vacuolar proton pump (V-ATPase), a
CC multimeric enzyme that catalyzes the translocation of protons across
CC the membranes. Required for assembly and activity of the V-ATPase.
CC {ECO:0000256|RuleBase:RU361189}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC {ECO:0000256|ARBA:ARBA00009904, ECO:0000256|RuleBase:RU361189}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PCD45889.1}.
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DR EMBL; MABQ02000001; PCD45889.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2H3I8E5; -.
DR STRING; 327505.A0A2H3I8E5; -.
DR OrthoDB; 1967517at2759; -.
DR Proteomes; UP000219602; Chromosome 1.
DR GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:InterPro.
DR InterPro; IPR002490; V-ATPase_116kDa_su.
DR InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR PANTHER; PTHR11629:SF63; V-TYPE PROTON ATPASE SUBUNIT A; 1.
DR PANTHER; PTHR11629; VACUOLAR PROTON ATPASES; 1.
DR Pfam; PF01496; V_ATPase_I; 1.
DR PIRSF; PIRSF001293; ATP6V0A1; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Hydrogen ion transport {ECO:0000256|ARBA:ARBA00022781,
KW ECO:0000256|RuleBase:RU361189};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU361189};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361189};
KW Reference proteome {ECO:0000313|Proteomes:UP000219602};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361189};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361189};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361189}.
FT TRANSMEM 422..446
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 458..483
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 548..566
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 578..603
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 642..662
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 754..773
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 785..808
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT REGION 157..183
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 101..128
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 279..306
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 857 AA; 97447 MW; EE072D1148FFD36E CRC64;
MAPKPDTPFR SADMSMVQLY VSNEIGREVV TALGELGLCQ FRDLNEDVSA FQRTFTQEIR
RLDNVERQLR YFYAQMDKIG IPLRKLDLDV ERLASPSTSE IDELAERSQK LEQRVSALNE
SYETLKKREG DLTEWRWVLR EAGSFFDRAH GNVEEIRAST DNDDAPLLSD IEQNQGGPDA
ERSFSGMNIG FVAGVIARDR VASFERILWR TLRGNLYMNQ SEIPEPLIDP TNNEAINKNV
FVIFAHGKEI LNKIRKISES MGADVYNVDE NSDLRRDQIH EVNNRLEDVQ NVLQNTQATL
QAELNQISQS LSAWMVLVAK EKAVYNALNN FSYDSARRTL IAEAWVPTND LPLIRTTLQD
VTNRAGLSVP SIINKIQTNK TPPTYLKTNK ITEGFQTIVN AYGTATYQEV NPAIPVFVTF
PFLFAVMFGD FGHAIIMLSA ALAMIYWEKS LKKVSFELFA MIFYGRYIAL VMAVFSVFTG
LIYNDVFSMS MTLFESAWEF KKPENYTNTT SIVATLREDG HRYPFGLDYA WHGSENDLLF
SNSLKMKMSI LLGWAHMTYS LCFSYINARH FKKPIDIWGN FIPGMIFFQS IFGYLVICIV
YKWSVDWLGT GRQPPGLLNM LIYMFLQPGT IPEGEELYAG QSVVQVILLL LAFVQVPILL
FLKPFYLRWE NSRARAKGYR SIGETSRVSA LDGDDEDANG HGNSFDEDGE GVAMISQNIS
EEHEEFEFSE VMIHQVIHTI EFCLNCVSHT ASYLRLWALS LAHQQLSIVL WSMTLGPALK
MSGVVGVIMI VVCFTMWFFL TIAILVCMEG TSAMLHSLRL AWVESFSKFA EFAGWPFAPF
SFNTLLEESE ELKDYLG
//
