ID   A0A2H3IB83_9EURO        Unreviewed;       919 AA.
AC   A0A2H3IB83;
DT   31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT   31-JAN-2018, sequence version 1.
DT   24-JAN-2024, entry version 15.
DE   RecName: Full=Anaphase-promoting complex subunit 2 {ECO:0000256|ARBA:ARBA00016068};
GN   ORFNames=PENO1_056340 {ECO:0000313|EMBL:PCG98786.1};
OS   Penicillium occitanis (nom. inval.).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium.
OX   NCBI_TaxID=290292 {ECO:0000313|EMBL:PCG98786.1, ECO:0000313|Proteomes:UP000218381};
RN   [1] {ECO:0000313|EMBL:PCG98786.1, ECO:0000313|Proteomes:UP000218381}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CL100 {ECO:0000313|EMBL:PCG98786.1,
RC   ECO:0000313|Proteomes:UP000218381};
RX   PubMed=28951729; DOI=10.3389/fmicb.2017.01627;
RA   Bravo-Ruiz G., Sassi A.H., Marcet-Houben M., Di Pietro A., Gargouri A.,
RA   Gabaldon T., Roncero M.I.G.;
RT   "Regulatory Mechanisms of a Highly Pectinolytic Mutant of Penicillium
RT   occitanis and Functional Analysis of a Candidate Gene in the Plant Pathogen
RT   Fusarium oxysporum.";
RL   Front. Microbiol. 8:1627-1627(2017).
CC   -!- SIMILARITY: Belongs to the cullin family. {ECO:0000256|PROSITE-
CC       ProRule:PRU00330, ECO:0000256|RuleBase:RU003829}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PCG98786.1}.
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DR   EMBL; NPFK01000153; PCG98786.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2H3IB83; -.
DR   STRING; 290292.A0A2H3IB83; -.
DR   OrthoDB; 2786196at2759; -.
DR   Proteomes; UP000218381; Unassembled WGS sequence.
DR   GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:InterPro.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR   Gene3D; 1.20.1310.10; Cullin Repeats; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR044554; APC2-like.
DR   InterPro; IPR014786; APC2_C.
DR   InterPro; IPR016158; Cullin_homology.
DR   InterPro; IPR036317; Cullin_homology_sf.
DR   InterPro; IPR001373; Cullin_N.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR45957; ANAPHASE-PROMOTING COMPLEX SUBUNIT 2; 1.
DR   PANTHER; PTHR45957:SF1; ANAPHASE-PROMOTING COMPLEX SUBUNIT 2; 1.
DR   Pfam; PF08672; ANAPC2; 1.
DR   Pfam; PF00888; Cullin; 1.
DR   SMART; SM01013; APC2; 1.
DR   SMART; SM00182; CULLIN; 1.
DR   SUPFAM; SSF75632; Cullin homology domain; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS50069; CULLIN_2; 1.
PE   3: Inferred from homology;
KW   Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW   Cell division {ECO:0000256|ARBA:ARBA00022618};
KW   Mitosis {ECO:0000256|ARBA:ARBA00022776};
KW   Reference proteome {ECO:0000313|Proteomes:UP000218381};
KW   Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT   DOMAIN          571..784
FT                   /note="Cullin family profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50069"
FT   REGION          805..824
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   919 AA;  102729 MW;  BB7066FA0A895161 CRC64;
     MSQIDPLARS RKRVFNSVFA PVELSEYAPT PLATPALGST AAGQPFGSAT VSKTAVSEVP
     VPEAVIWNRA WHSAAEFLQF PDRTFDTPSS YLEYAKHNSL KKQITPEAAE ALTYLMSPSS
     PGRYLYQGLK ESDLIYWYCN EIRRHFITNV QPILCTALKK GLEGDPLTQT MRCLHLTQHT
     YFTPFWDHVA PNLDPTETDT SHSRLKETFQ SIVAHSLPSK RISDLLEESI RNAAVDILGI
     SQARDDEADD TESNDMEIDQ QLSIIYRLWK EMSPETARYE VISEYHDDRM SQSRNRLLTL
     LHAMQEFGLG GHRAQKVFAQ VMNDMMTEFI IVSYKEQWDS PSLVREHLCL WVENVFARLA
     VEVLEILQPS SGDMDDDIIN VRLDDVGKWQ EIGLARLGAL RTSELFDVIV HWDSSSGAIE
     DLKQYTTHTA SRFSLSTAFV GTLTQRLLHP GASTAEILKL YISIIRAFSL LDPKGVLLDR
     AARPIRKYLR DRDDTVQVIV GGLLADPSDA DNAEDKETLV ELATELNTAH QRNLQNDSGE
     LDWDDMSWMP DPIDAAADYK KSKGADVVGS LISLFDSKEA FVKELQSMLS ERLLKKKPNF
     DQETSVLELL KVRFGDGALQ ACEVMLRDVL DSKRVDTVIR DDQELAGQQL PAWGKAAPAQ
     KSYNIPQLHS KILSKFFWPA IQDQPFDVPE EIKTLQERYS AGFEALKQSR KLTWLNSLGH
     VTVELDMEDR VFTDEVTTWQ ATVIYAFQPG SRSDNAPVTK TVAEVAETLK MSAALVRSAC
     LYWVSKRILT ETQRDSFRVL EVLPNDGDHE MSTSGDQEGA DPSATEADAA AAADAAAAAA
     AKETAHAAAM EKMNLYWQFI VGMLTNQGAM PLQRIIMMLK IAVPGGFPFG NEELREFLAG
     MVAQGKLEIV SGGSYKLVR
//