ID A0A2H3IS19_9EURO Unreviewed; 387 AA.
AC A0A2H3IS19;
DT 31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT 31-JAN-2018, sequence version 1.
DT 27-MAR-2024, entry version 12.
DE SubName: Full=3-beta hydroxysteroid dehydrogenase/isomerase {ECO:0000313|EMBL:PCG96887.1};
GN ORFNames=PENO1_066010 {ECO:0000313|EMBL:PCG96887.1};
OS Penicillium occitanis (nom. inval.).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium.
OX NCBI_TaxID=290292 {ECO:0000313|EMBL:PCG96887.1, ECO:0000313|Proteomes:UP000218381};
RN [1] {ECO:0000313|EMBL:PCG96887.1, ECO:0000313|Proteomes:UP000218381}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CL100 {ECO:0000313|EMBL:PCG96887.1,
RC ECO:0000313|Proteomes:UP000218381};
RX PubMed=28951729; DOI=10.3389/fmicb.2017.01627;
RA Bravo-Ruiz G., Sassi A.H., Marcet-Houben M., Di Pietro A., Gargouri A.,
RA Gabaldon T., Roncero M.I.G.;
RT "Regulatory Mechanisms of a Highly Pectinolytic Mutant of Penicillium
RT occitanis and Functional Analysis of a Candidate Gene in the Plant Pathogen
RT Fusarium oxysporum.";
RL Front. Microbiol. 8:1627-1627(2017).
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004406}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004406}.
CC -!- SIMILARITY: Belongs to the 3-beta-HSD family.
CC {ECO:0000256|ARBA:ARBA00009219}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PCG96887.1}.
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DR EMBL; NPFK01000200; PCG96887.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2H3IS19; -.
DR STRING; 290292.A0A2H3IS19; -.
DR OrthoDB; 1133at2759; -.
DR Proteomes; UP000218381; Unassembled WGS sequence.
DR GO; GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IEA:InterPro.
DR GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-KW.
DR GO; GO:0006694; P:steroid biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR002225; 3Beta_OHSteriod_DH/Estase.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43245; BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA; 1.
DR PANTHER; PTHR43245:SF51; SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY 42E, MEMBER 2; 1.
DR Pfam; PF01073; 3Beta_HSD; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Isomerase {ECO:0000313|EMBL:PCG96887.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000218381}.
FT DOMAIN 20..300
FT /note="3-beta hydroxysteroid dehydrogenase/isomerase"
FT /evidence="ECO:0000259|Pfam:PF01073"
SQ SEQUENCE 387 AA; 42786 MW; 60A6D138D3C2C952 CRC64;
MSEQIPQTNH PEKDEGLKVI ITGGAGCIGF ATIKSLLKHH PNASIHVLDL TIPSLEVYPF
SNFQEKKNQL HFYKADITSP TSLSAVFDAV RPQAVIHTAS IIPSAARKRQ LNNEGLWKVN
VEGTRNILDI AERTEEVKAL VYTSSCDAVK PDSWMDFVNA TESSTQHLRD TDIKGWDNGA
KAAAETLVLS SDLRIKTCAI RTHGVVGTLD QNLFPLVATS PRKISLGSGK NLYDFTSADN
VGLAHVLAMN NLLGLSSTNK DREEKESANR RAFFITDGNP KPFRELQEMI WRVVDDDDPE
ASYAKYTVIP VWLFKGILKI AGLFTKATIS PVEVGDAVSM RYYDIGEARR VLGYRPEGNK
GLEESMRDAS EWWKMSSMSI SAKGGKK
//