ID   A0A2H3IYB8_9EURO        Unreviewed;      1035 AA.
AC   A0A2H3IYB8;
DT   31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT   31-JAN-2018, sequence version 1.
DT   08-NOV-2023, entry version 21.
DE   SubName: Full=Ras GTPase-activating protein {ECO:0000313|EMBL:PCH01292.1};
GN   ORFNames=PENO1_043640 {ECO:0000313|EMBL:PCH01292.1};
OS   Penicillium occitanis (nom. inval.).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium.
OX   NCBI_TaxID=290292 {ECO:0000313|EMBL:PCH01292.1, ECO:0000313|Proteomes:UP000218381};
RN   [1] {ECO:0000313|EMBL:PCH01292.1, ECO:0000313|Proteomes:UP000218381}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CL100 {ECO:0000313|EMBL:PCH01292.1,
RC   ECO:0000313|Proteomes:UP000218381};
RX   PubMed=28951729; DOI=10.3389/fmicb.2017.01627;
RA   Bravo-Ruiz G., Sassi A.H., Marcet-Houben M., Di Pietro A., Gargouri A.,
RA   Gabaldon T., Roncero M.I.G.;
RT   "Regulatory Mechanisms of a Highly Pectinolytic Mutant of Penicillium
RT   occitanis and Functional Analysis of a Candidate Gene in the Plant Pathogen
RT   Fusarium oxysporum.";
RL   Front. Microbiol. 8:1627-1627(2017).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PCH01292.1}.
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DR   EMBL; NPFK01000103; PCH01292.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2H3IYB8; -.
DR   STRING; 290292.A0A2H3IYB8; -.
DR   OrthoDB; 22721at2759; -.
DR   Proteomes; UP000218381; Unassembled WGS sequence.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR   CDD; cd00030; C2; 1.
DR   CDD; cd05137; RasGAP_CLA2_BUD2; 1.
DR   Gene3D; 2.60.40.150; C2 domain; 1.
DR   InterPro; IPR000008; C2_dom.
DR   InterPro; IPR035892; C2_domain_sf.
DR   InterPro; IPR039360; Ras_GTPase.
DR   InterPro; IPR023152; RasGAP_CS.
DR   InterPro; IPR001936; RasGAP_dom.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   PANTHER; PTHR10194:SF60; GTPASE-ACTIVATING PROTEIN; 1.
DR   PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR   Pfam; PF00168; C2; 1.
DR   Pfam; PF00616; RasGAP; 1.
DR   SMART; SM00323; RasGAP; 1.
DR   SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR   SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR   PROSITE; PS50004; C2; 1.
DR   PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR   PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE   4: Predicted;
KW   GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW   Reference proteome {ECO:0000313|Proteomes:UP000218381}.
FT   DOMAIN          293..458
FT                   /note="C2"
FT                   /evidence="ECO:0000259|PROSITE:PS50004"
FT   DOMAIN          513..752
FT                   /note="Ras-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50018"
FT   REGION          932..1035
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        954..968
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        986..1014
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1035 AA;  116863 MW;  B4FDAA644A91BFD3 CRC64;
     MKTTCGRMHG ILSFRTATNA QWTSGYCAIN VASGSLIYQA KGEVAMAKTL IPDLRGCHVR
     TMFDTELQST YLSVSTFSSG LGIQLKPHVN ETFDSWLAAL LCWQPIRPKG VQNKRTKPQS
     VAIGDRRIAD RRRNSESTVQ KEAAIIKVGK MLLWEKPSPS GARPESGWQA STQHRNHRTH
     STAWQRVSCT LQENGYFKLF TEADVSLLAV IHLSQLSRCA IQQLEPSVLG DEYCIAIYPQ
     YAALSTTETA SRPVFLSLES RVLFEVWFVL LRAFTIPELY GPETAASEDP TRSQTLINPA
     AASTTDMFRI ERMLSLRITE AKLTGNKNKS EESPKSKKPF DPNEKTFVSD YYAEVLLDGE
     IRAKTAVKQR TSNPFWREEF SFHDLPPILS NASILLKTLN PAQKDWTLIA HGPYSLDSQS
     NPLSVLDDLE LSSHDATSGR VDLRLDELET GVDHEKWWPI IDDRDQVMGE MYMKVRLEEM
     IVLMSHEYEP MSEILHMFPN NLTINMIHLV PTELTRISEI LLNIFQVSGQ AADWISALVE
     DEIDGFDRDT TSTAHHRFRY ATRIHSNDSK ESGQDREVIV RDLGRSATIE ANLLFRGNSL
     LTKALDMHMR RLGKDYLEET IGDRIRDLDE SDPECEVDPL KLRYNRSDEL ARNWRNLISL
     TTLFWKSIAA SASRCPAELR RIFRHVRACA EDRYGDFLRS VTYSSVSGFL FLRFFCPAIL
     NPKLFGLMKE HPRPRAQRTL TLIAKALQGL ANMTNFGNKE PWMEPMNTFL QSNRTAFKEF
     VDSICAIPAE RPAAIVTPQY ATPIQILGRL PPTSREGFPS LPFLIDHARS FAALTKLWLQ
     KAPERLNELE EVEPSVAKFH SLALEIQRRT KECFSKAESA ERPSGNLEMK WEELVESMDR
     SITFYDEASK PATPAAETPL TAPAVVSSHR NSIGYFAPRP SPPPRRSTDA TADGEDETPP
     SSSSATWEHY RLPFAVGRSS DHRESGTSSR NSSQYSLENP DNSKSRQSTI GKEASSKLRL
     LDFVPGPSRR KNKDS
//