ID A0A2H3J5F4_WOLCO Unreviewed; 1168 AA.
AC A0A2H3J5F4;
DT 31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT 31-JAN-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN ORFNames=WOLCODRAFT_140635 {ECO:0000313|EMBL:PCH36905.1};
OS Wolfiporia cocos (strain MD-104) (Brown rot fungus).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Polyporales; Phaeolaceae; Wolfiporia.
OX NCBI_TaxID=742152 {ECO:0000313|EMBL:PCH36905.1, ECO:0000313|Proteomes:UP000218811};
RN [1] {ECO:0000313|EMBL:PCH36905.1, ECO:0000313|Proteomes:UP000218811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MD-104 {ECO:0000313|EMBL:PCH36905.1,
RC ECO:0000313|Proteomes:UP000218811};
RX PubMed=22745431; DOI=10.1126/science.1221748;
RA Floudas D., Binder M., Riley R., Barry K., Blanchette R.A., Henrissat B.,
RA Martinez A.T., Otillar R., Spatafora J.W., Yadav J.S., Aerts A., Benoit I.,
RA Boyd A., Carlson A., Copeland A., Coutinho P.M., de Vries R.P.,
RA Ferreira P., Findley K., Foster B., Gaskell J., Glotzer D., Gorecki P.,
RA Heitman J., Hesse C., Hori C., Igarashi K., Jurgens J.A., Kallen N.,
RA Kersten P., Kohler A., Kuees U., Kumar T.K.A., Kuo A., LaButti K.,
RA Larrondo L.F., Lindquist E., Ling A., Lombard V., Lucas S., Lundell T.,
RA Martin R., McLaughlin D.J., Morgenstern I., Morin E., Murat C., Nagy L.G.,
RA Nolan M., Ohm R.A., Patyshakuliyeva A., Rokas A., Ruiz-Duenas F.J.,
RA Sabat G., Salamov A., Samejima M., Schmutz J., Slot J.C., St John F.,
RA Stenlid J., Sun H., Sun S., Syed K., Tsang A., Wiebenga A., Young D.,
RA Pisabarro A., Eastwood D.C., Martin F., Cullen D., Grigoriev I.V.,
RA Hibbett D.S.;
RT "The Paleozoic origin of enzymatic lignin decomposition reconstructed from
RT 31 fungal genomes.";
RL Science 336:1715-1719(2012).
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DR EMBL; KB467898; PCH36905.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2H3J5F4; -.
DR STRING; 742152.A0A2H3J5F4; -.
DR OMA; QCYEKDY; -.
DR OrthoDB; 1630at2759; -.
DR Proteomes; UP000218811; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0004521; F:RNA endonuclease activity; IEA:InterPro.
DR GO; GO:0030968; P:endoplasmic reticulum unfolded protein response; IEA:InterPro.
DR GO; GO:0006397; P:mRNA processing; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd09769; Luminal_IRE1; 1.
DR CDD; cd10422; RNase_Ire1; 1.
DR Gene3D; 1.20.1440.180; KEN domain; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR045133; IRE1/2-like.
DR InterPro; IPR010513; KEN_dom.
DR InterPro; IPR038357; KEN_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR13954; IRE1-RELATED; 1.
DR PANTHER; PTHR13954:SF6; NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE; 1.
DR Pfam; PF00069; Pkinase; 1.
DR Pfam; PF06479; Ribonuc_2-5A; 1.
DR SMART; SM00580; PUG; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 1.
DR PROSITE; PS51392; KEN; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022527};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000218811};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..1168
FT /note="non-specific serine/threonine protein kinase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5013796556"
FT DOMAIN 732..1031
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 1034..1166
FT /note="KEN"
FT /evidence="ECO:0000259|PROSITE:PS51392"
FT REGION 548..581
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 597..704
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 920..946
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 548..570
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 602..616
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 632..663
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1168 AA; 126820 MW; 18546580A5683AD5 CRC64;
MTINGLLLAL LTAGKCLAEV SPHRTATRIT DLSTRVAVPH ERYHSGGSDG FDLLDIVLVA
SIDGKLHALN RTSGDSLWSM TASSGVAPVT LGPLVRTQHP DIDPDLTDDD SVHQEVYVVE
PQSGDIFVLP TPNSPLQRLP FSMPQLVDMS PFKFSGDDDA RVFVGKKETS LLLIELETGR
VKATLSSECP WDPFQDLAGP AAFDVDLDEL EGSKQPERPT EVYIGRTDYH VSIYTRPTRP
SSTRPPIQNL SFSVYGPNNE DLALQSLYRH TADSAYIQPL PNGQVLCFKS DALETPKPDP
SLLWGQAFPN PIVAVFDVLH APKRQHPFVL LQPHLRLEDI LPHADLRTSR HPDFDRAFVG
IVEETGSLFA MSPDNFPLVV FGDAGAGRFL DAAPDADADT DGGGDHERDF PSRIDMVARR
AKERSLRRMC RESSTDRRCL TGVRKLESST QSRFSRLLDA APVSAAPMTT DSAQENASGA
SASAGAAAGA DGASVSAVLM WDSQRDYAEV GGKYLGGAAT AQALSAFTAC TLALLVVIWY
AVRSRPDRQR AASSEDKAGP ASDAREEVKA EMPSVNGVTT NGAIAGLPLE LVAGVPPTAS
AEERSETPSP LTLSPSTPGK RVAFLTDDGE SDSPMPDARD TGEEPVGAED TDKEGDAPAT
PGKRKGPRRK RGKKKKGGAA GNGAADGAEQ EKESVEATAA VDSSAEDGKL IVPVEPVSMP
ATPVPAASQS LVVSDTVLGF GSHGTVVFKG SLQGRAVAVK RLLQDFVTLA AREVNILQES
DDHPNVIRYY YQESQANFLY IALELCPASL ADIVERPDNF SDIVLAFEPK RALRQITAGL
RHLHALKIVH RDIKPQNILI SHAKKGVGES AGHRMLISDF GLCRKLDYDQ TSFLPTSHGA
MAAGTVGWRA PEILRGEVKL DDSGGEESQS SRGSVGAPAI GTPTGKPTRL TKSVDIFALG
CLYYYVLTNG GHPFGDRFER ESNILKNAKS LDGLVRFGEE GSEGADLIAR MLSPEAYDRP
DTSTCLLHPY FWDPAKRLTF LQDASDRFEI MCRDPRDPNL TLLETGAFNV VGNDWHSRLD
RLFIENLGKF RKYDGRSVQD LLRALRNKKH HYQDLPDNVK RLLGSMPEGF LAYFTQRFPQ
LLLHVHSVVS ASSLRNESMF RTYYELTD
//
