ID A0A2H3JF43_WOLCO Unreviewed; 1248 AA.
AC A0A2H3JF43;
DT 31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT 31-JAN-2018, sequence version 1.
DT 13-SEP-2023, entry version 16.
DE SubName: Full=Urea amidolyase {ECO:0000313|EMBL:PCH34617.1};
GN ORFNames=WOLCODRAFT_133538 {ECO:0000313|EMBL:PCH34617.1};
OS Wolfiporia cocos (strain MD-104) (Brown rot fungus).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Polyporales; Phaeolaceae; Wolfiporia.
OX NCBI_TaxID=742152 {ECO:0000313|EMBL:PCH34617.1, ECO:0000313|Proteomes:UP000218811};
RN [1] {ECO:0000313|EMBL:PCH34617.1, ECO:0000313|Proteomes:UP000218811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MD-104 {ECO:0000313|EMBL:PCH34617.1,
RC ECO:0000313|Proteomes:UP000218811};
RX PubMed=22745431; DOI=10.1126/science.1221748;
RA Floudas D., Binder M., Riley R., Barry K., Blanchette R.A., Henrissat B.,
RA Martinez A.T., Otillar R., Spatafora J.W., Yadav J.S., Aerts A., Benoit I.,
RA Boyd A., Carlson A., Copeland A., Coutinho P.M., de Vries R.P.,
RA Ferreira P., Findley K., Foster B., Gaskell J., Glotzer D., Gorecki P.,
RA Heitman J., Hesse C., Hori C., Igarashi K., Jurgens J.A., Kallen N.,
RA Kersten P., Kohler A., Kuees U., Kumar T.K.A., Kuo A., LaButti K.,
RA Larrondo L.F., Lindquist E., Ling A., Lombard V., Lucas S., Lundell T.,
RA Martin R., McLaughlin D.J., Morgenstern I., Morin E., Murat C., Nagy L.G.,
RA Nolan M., Ohm R.A., Patyshakuliyeva A., Rokas A., Ruiz-Duenas F.J.,
RA Sabat G., Salamov A., Samejima M., Schmutz J., Slot J.C., St John F.,
RA Stenlid J., Sun H., Sun S., Syed K., Tsang A., Wiebenga A., Young D.,
RA Pisabarro A., Eastwood D.C., Martin F., Cullen D., Grigoriev I.V.,
RA Hibbett D.S.;
RT "The Paleozoic origin of enzymatic lignin decomposition reconstructed from
RT 31 fungal genomes.";
RL Science 336:1715-1719(2012).
CC -!- COFACTOR:
CC Name=biotin; Xref=ChEBI:CHEBI:57586;
CC Evidence={ECO:0000256|ARBA:ARBA00001953};
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DR EMBL; KB467832; PCH34617.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2H3JF43; -.
DR STRING; 742152.A0A2H3JF43; -.
DR OMA; TLQMWNR; -.
DR OrthoDB; 313213at2759; -.
DR Proteomes; UP000218811; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR CDD; cd06850; biotinyl_domain; 1.
DR Gene3D; 2.40.50.100; -; 1.
DR Gene3D; 3.30.1360.40; -; 1.
DR Gene3D; 3.30.470.20; ATP-grasp fold, B domain; 1.
DR Gene3D; 2.40.100.10; Cyclophilin-like; 2.
DR InterPro; IPR011761; ATP-grasp.
DR InterPro; IPR005481; BC-like_N.
DR InterPro; IPR001882; Biotin_BS.
DR InterPro; IPR011764; Biotin_carboxylation_dom.
DR InterPro; IPR005482; Biotin_COase_C.
DR InterPro; IPR000089; Biotin_lipoyl.
DR InterPro; IPR005479; CbamoylP_synth_lsu-like_ATP-bd.
DR InterPro; IPR003778; CT_A_B.
DR InterPro; IPR003833; CT_C_D.
DR InterPro; IPR029000; Cyclophilin-like_dom_sf.
DR InterPro; IPR016185; PreATP-grasp_dom_sf.
DR InterPro; IPR011054; Rudment_hybrid_motif.
DR InterPro; IPR011053; Single_hybrid_motif.
DR NCBIfam; TIGR00724; urea_amlyse_rel; 1.
DR PANTHER; PTHR18866; CARBOXYLASE:PYRUVATE/ACETYL-COA/PROPIONYL-COA CARBOXYLASE; 1.
DR PANTHER; PTHR18866:SF33; METHYLCROTONOYL-COA CARBOXYLASE SUBUNIT ALPHA, MITOCHONDRIAL-RELATED; 1.
DR Pfam; PF02785; Biotin_carb_C; 1.
DR Pfam; PF00289; Biotin_carb_N; 1.
DR Pfam; PF00364; Biotin_lipoyl; 1.
DR Pfam; PF02786; CPSase_L_D2; 1.
DR Pfam; PF02626; CT_A_B; 1.
DR Pfam; PF02682; CT_C_D; 1.
DR SMART; SM00796; AHS1; 1.
DR SMART; SM00797; AHS2; 1.
DR SMART; SM00878; Biotin_carb_C; 1.
DR SUPFAM; SSF50891; Cyclophilin-like; 2.
DR SUPFAM; SSF56059; Glutathione synthetase ATP-binding domain-like; 1.
DR SUPFAM; SSF160467; PH0987 N-terminal domain-like; 1.
DR SUPFAM; SSF52440; PreATP-grasp domain; 1.
DR SUPFAM; SSF51246; Rudiment single hybrid motif; 1.
DR SUPFAM; SSF51230; Single hybrid motif; 1.
DR PROSITE; PS50975; ATP_GRASP; 1.
DR PROSITE; PS50979; BC; 1.
DR PROSITE; PS00188; BIOTIN; 1.
DR PROSITE; PS00866; CPSASE_1; 1.
DR PROSITE; PS00867; CPSASE_2; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00409}; Biotin {ECO:0000256|ARBA:ARBA00023267};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Lyase {ECO:0000313|EMBL:PCH34617.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00409}; Reference proteome {ECO:0000313|Proteomes:UP000218811}.
FT DOMAIN 3..471
FT /note="Biotin carboxylation"
FT /evidence="ECO:0000259|PROSITE:PS50979"
FT DOMAIN 127..328
FT /note="ATP-grasp"
FT /evidence="ECO:0000259|PROSITE:PS50975"
SQ SEQUENCE 1248 AA; 136375 MW; 71ADE759E15333F7 CRC64;
MDVGHKLLVA NRGEIAVRVL RTAKRLGLRT VAIYTRTDAT SPHVVLADES VALNPDDTDS
VSNARGYLDA ETIVAICRAH RVTLVHPGYG FLSENAHFAS LLAEAGVTFL GPKNETIQAM
GLKHEARILA TAVDVPLVPG SQGLIENVED AVLLADRIGY PVMLKSTAGG GGMGLVMCQN
ANELRVKFVA TQERATTLFK NGGVFLERYY PSARHVEVQV FGNGLGHAIH IGERECSVQR
RHQKVIEESP SPFMIGYPDV GQRMCTAAIR LCQHINYASA GTVEFLVDDA TGDFFFLEMN
TRLQVEHPVT EATNPGLDIV ELMIRQGVAE RNTELGGLAA NQLSQEPYNI PSHKRPLHAI
EARVYCENPA AQFKPSPGVL QKVEFMQAEW LRVETWVETG TTVTPYFDPL VCKLIVTGTN
RQQAIDRLEV ALAGCKVHGP PNNMAYLRAI CQSEVFRAGN TMTTYLDTFN FVPRTMDVLS
GGLETTVQDY PGRRIGMGIP RGGPMDSLAF RAANILVGND PGTEALEITL VGCKVLFHVP
TVIAVAGAPV RVTVNGQEAQ TWSSILVPAG GKVAVGTINS VGFRAYLAVR GGFPEIPVYL
GSKSTSIGLG GYQGRALTAG DHLALGDCGP VQDEQPTTVP DSLRPSYPSD WVIYCLQGPH
CDEEFVTAEG IEKFCSTKWK VSTSSNRMGI RLEGPSILWA RRTGGEGGSH PSNIHDNGYA
FGTINVNGDT PVILTNDGPD MGGYTCLCTI ATEELWKIGQ LRPGSTVQFR RISPAQSVSM
VALRERYFTQ LAEAARSSAL KSVPEKADLF DQVFEDCSQD PKIHTIVPLE GSMRPKVVFR
QAGDSAILVE FGELQLDFML RARIHAFETE LRRRSVQGIW SLAPCIRSTM IHYDPCSISQ
AALLSVLVDV ETSLPDNLEE TVFPARRITF PIVLDDRWNR EALQRYMRSI RDEAAYLPSN
IEYLARNNGL AGGVEEALKA LISSDWLVFG VGFYMACPFL IPIDPRCRLV GQKMNPSRTF
TPRGAVGIAG LVAAIYPIES PGGYQLFGRS LSPWQTWGKG PDFDLEKPWL LQPFDQVAFQ
PVTEEEYIQL ESQLDAGRYA FKIEPSNFSI SEYSSFIRGI SEQVKQFKER QARGVESEEA
RETELFAKWV ERKAEAHSTV HETANSNDAF AVGDGIVSSM SASIWRIKCK PGDVISSAGD
VVVILEAMKT EINIEAGEEN IGRKVMGFGK GVKEGAAVNA GDVLVVLQ
//
