ID A0A2H3KKG8_9CHLR Unreviewed; 1795 AA.
AC A0A2H3KKG8;
DT 31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT 31-JAN-2018, sequence version 1.
DT 24-JAN-2024, entry version 15.
DE RecName: Full=Alpha-2-macroglobulin {ECO:0008006|Google:ProtNLM};
GN ORFNames=A9Q02_15485 {ECO:0000313|EMBL:PDV98429.1};
OS Candidatus Chloroploca asiatica.
OC Bacteria; Chloroflexota; Chloroflexia; Chloroflexales; Chloroflexineae;
OC Oscillochloridaceae; Candidatus Chloroploca.
OX NCBI_TaxID=1506545 {ECO:0000313|EMBL:PDV98429.1, ECO:0000313|Proteomes:UP000220922};
RN [1] {ECO:0000313|EMBL:PDV98429.1, ECO:0000313|Proteomes:UP000220922}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B7-9 {ECO:0000313|EMBL:PDV98429.1,
RC ECO:0000313|Proteomes:UP000220922};
RA Lavstsen T., Jespersen J.S.;
RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PDV98429.1}.
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DR EMBL; LYXE01000101; PDV98429.1; -; Genomic_DNA.
DR Proteomes; UP000220922; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004866; F:endopeptidase inhibitor activity; IEA:InterPro.
DR Gene3D; 1.50.10.20; -; 1.
DR Gene3D; 2.60.40.1930; -; 1.
DR Gene3D; 2.60.40.3710; -; 2.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR011625; A2M_N_BRD.
DR InterPro; IPR041246; Bact_MG10.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR001599; Macroglobln_a2.
DR InterPro; IPR032812; SbsA_Ig.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR PANTHER; PTHR40094; ALPHA-2-MACROGLOBULIN HOMOLOG; 1.
DR PANTHER; PTHR40094:SF1; UBIQUITIN DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF07703; A2M_BRD; 1.
DR Pfam; PF13205; Big_5; 4.
DR Pfam; PF17973; bMG10; 1.
DR SMART; SM01360; A2M; 1.
DR SMART; SM01359; A2M_N_2; 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000220922};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..32
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 971..1106
FT /note="Alpha-2-macroglobulin bait region"
FT /evidence="ECO:0000259|SMART:SM01359"
FT DOMAIN 1150..1243
FT /note="Alpha-2-macroglobulin"
FT /evidence="ECO:0000259|SMART:SM01360"
SQ SEQUENCE 1795 AA; 190814 MW; A1304CDC8EE51A68 CRC64;
MAVLRLLARI WLVLLGTTTL VLVLAVLARW FIPLTPWASV PTLLAINPPD GAVDVRPRDA
LALQFAVPMN RASVEQALSI EPLVPGDLLW SPDAQTLTLR PTERLTSAMT YTVRLDQVAL
SRWWRPLEDP VEVVFRTAVE PAVLAALPKG DGIALDTAVA LVFSQPMVAP DQVQQPFTPT
FLQLEPSAEV AGQWLDQFTL LIRPLRPLLP ATDYTVTVAA TLTDLRGIEL GTPVSWAFAT
RWPVWHSRTP EPGASAVTPR TTLSFVLDAP VPLEQLRQAL VMSPTIEGEL ATAQVGATQV
VTFTPTSGWA YGTSYAVQLG ESPSGQRGAA EIWRFQVEPQ PRLIAFFPGQ GQILPPEETI
RLIFSTPMDA TSLEANVRFE PPVADLALTT SSSEVLLRPE LEPSTLYTLT VAADARDRNG
EPLGTDAVVS LRTAPATPSL AVPGAFADLV SLEPSMPATL DLALRNVSGL NVSLYPLDQP
ALLRFMALRP EERAGFVPER YGQAPSRIWR APGTTGPDQL VRQSLPIGPV DGEPLDPGAY
YVRLTTPEGP RADLVVLVNT TRLLVQHYPN QVLIWASDRA GTPRGDLPVA LFRNERLVAR
GRTDANGTWI ASGLTENTGS LLALTEDGEP AVVQTDWRLV TPDATRPSFS ALLFPDQSIY
HPGETITVTG FAGQQSGNLL ASPPTCRLQL RQPIGNPVGL ATTCQFEPTT GLVSGTLVLA
SRTAPGPYRL AATLGDAQIL MPVRVVSPGA PSFELKATPL NERELEVTVQ RNGLPPLETR
LAWSLTLEAV APPAPPDGFV ADTPALPTPL TLTGEGQTDA QGRLKLSLPT SGEGLHAMTY
VLLVTIDGQP EPVMVEGVLT PGRNNLALRL PRRLVATDQR SQVEVLVRDG RGQAVANVPV
QLEVLRADNA TAPILTRQMV SDADGLASTE VVQLNPGEYN VLVRSGTVTH QQPLWVYGQR
FIGWSTNERR FALVTDRERY QPGDLARLLI AAPVSQGNIL LTIAGDGLQQ VEVLTVQPGQ
VFNLPITAEM APGIVLGAVI DTGSTYLAGT TRLLVEGEEA AQALRIASSP TEVRPGASVA
LTLTTSADPG QAASDLLVTL GAVEHLPNAV DLRLFAPEPS LAPVIAAVPP QGATVAPARL
NTPQPQLMPL AYRRVPALRP DGETVFAGTL DAPTTAGTWR LTAYAFGSNA RPVADATTLT
TTLPIATRLI APVILGPTDE GQIDLALTNT SPFSRTLTVR ATTSALELTP VSAGGQTISL
APGETTALAW QASLEPQVNE GSVRLAINGD ELGERLEHTL TRTTLLPTLT QQSITVARSG
ALTTRVDLAE SERLVLAFAP GLRAALATQA EALVQISDRS NEEVAALALI AAGLASSNDE
PEARLWVDVA RDALAELEGA QASDGGWGWW PGTTSEPFVT AFALEAQLAV RTLLNDPRPP
DLRAISYLGR VGSTVDADTR AYLTYVLHRA GRSDPGIGGV RSEGLEADGL AFLALTLPVN
QAAPLIDQLS SLAVREPARP GASTAIHWHS EQPGALPRSP TAITGAVTQA LRNRRPGSAD
LPGASQSLLE AWTARGWPSA YDAARVAVAL LPGSPATEAT SVRLTVDGVP VLDTEATVTR
TVRTELATTG LAAQPELRMT TSRDEPYLLA YQLLAVAPPD KARLFVLEQA LLDPTNGAPL
DPANLQVGQL ISIRLTTVII QPTLRADLRV KFPAGIEPLD LSAQAPWIHA AATSHDGQII
RLGGTNLVPG VYTHTITGRA RLAGRYSGPE AQLEALYEPE AGVSVTTDEV LTLAP
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