ID   A0A2H3NPE7_9BACT        Unreviewed;       446 AA.
AC   A0A2H3NPE7;
DT   31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT   31-JAN-2018, sequence version 1.
DT   27-MAR-2024, entry version 18.
DE   SubName: Full=Hydroxymethylglutaryl-CoA synthase {ECO:0000313|EMBL:PEN08830.1};
GN   ORFNames=CRI93_03505 {ECO:0000313|EMBL:PEN08830.1};
OS   Longimonas halophila.
OC   Bacteria; Rhodothermota; Rhodothermia; Rhodothermales; Salisaetaceae;
OC   Longimonas.
OX   NCBI_TaxID=1469170 {ECO:0000313|EMBL:PEN08830.1, ECO:0000313|Proteomes:UP000221024};
RN   [1] {ECO:0000313|EMBL:PEN08830.1, ECO:0000313|Proteomes:UP000221024}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KCTC 42399 {ECO:0000313|EMBL:PEN08830.1,
RC   ECO:0000313|Proteomes:UP000221024};
RA   Goh K.M., Shamsir M.S., Lim S.W.;
RT   "Draft genome of Longimonas halophila.";
RL   Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the thiolase-like superfamily. HMG-CoA synthase
CC       family. {ECO:0000256|ARBA:ARBA00007061}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PEN08830.1}.
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DR   EMBL; PDEP01000002; PEN08830.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2H3NPE7; -.
DR   OrthoDB; 9769523at2; -.
DR   Proteomes; UP000221024; Unassembled WGS sequence.
DR   GO; GO:0004421; F:hydroxymethylglutaryl-CoA synthase activity; IEA:InterPro.
DR   GO; GO:0006084; P:acetyl-CoA metabolic process; IEA:InterPro.
DR   GO; GO:0010142; P:farnesyl diphosphate biosynthetic process, mevalonate pathway; IEA:InterPro.
DR   CDD; cd00827; init_cond_enzymes; 1.
DR   Gene3D; 3.40.47.10; -; 1.
DR   InterPro; IPR013746; HMG_CoA_synt_C_dom.
DR   InterPro; IPR013528; HMG_CoA_synth_N.
DR   InterPro; IPR016039; Thiolase-like.
DR   NCBIfam; NF041302; HMG_CoAsyn_Halo; 1.
DR   PANTHER; PTHR43323; 3-HYDROXY-3-METHYLGLUTARYL COENZYME A SYNTHASE; 1.
DR   PANTHER; PTHR43323:SF2; HYDROXYMETHYLGLUTARYL-COA SYNTHASE; 1.
DR   Pfam; PF08540; HMG_CoA_synt_C; 1.
DR   Pfam; PF01154; HMG_CoA_synt_N; 1.
DR   SUPFAM; SSF53901; Thiolase-like; 2.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000221024}.
FT   DOMAIN          4..174
FT                   /note="Hydroxymethylglutaryl-coenzyme A synthase N-
FT                   terminal"
FT                   /evidence="ECO:0000259|Pfam:PF01154"
FT   DOMAIN          194..406
FT                   /note="Hydroxymethylglutaryl-coenzyme A synthase C-
FT                   terminal"
FT                   /evidence="ECO:0000259|Pfam:PF08540"
SQ   SEQUENCE   446 AA;  49036 MW;  8A3A4F8B814685B7 CRC64;
     MAAVGIDAME IWTGKLVLDL PNTFAPVKDE APAKYTKGLG LTGSSLPDVY EDIVTMGANA
     CKRLMERKGL TPNDIGRIDV ATESSFDRSK PASTYIAGCL EQVFDGDFSH TNKGERKFAC
     LSGTQAIDDA CNWIRAGRHR GRGALVVVTD TALYERDDPG EATQGAGAVA IYITETPSVV
     ALSREQGIGS KDETDFLKPN QQFPSVDGKR SIGVYLDRVR EALHDYESVA GRIHKADVAF
     LPFHTPFPGM VRKAALMTYR HLIDGTDEAN ALRELVGEAP DADAFDDAEA YKKARYDHQK
     AIRKTPLYRE WYEATVQPTL SLSRRTGNWY TGSVHIARAS ALLEAAQHDV DIAGQRMLVG
     SYGSGAQAEM HTETVCPGWH AEIDALTIVE QLDARYDLSF DEYERVHQAH TYDVEVAVEP
     FTTPNNEFVF SGYGAMGERQ YAYVSA
//