ID A0A2H3SS26_FUSOX Unreviewed; 1143 AA.
AC A0A2H3SS26;
DT 31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT 31-JAN-2018, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE SubName: Full=Related to polycomb group protein MEDEA {ECO:0000313|EMBL:SCO79268.1};
GN ORFNames=BFJ69_g852 {ECO:0000313|EMBL:RKK86628.1}, FRV6_03481
GN {ECO:0000313|EMBL:SCO79268.1};
OS Fusarium oxysporum (Fusarium vascular wilt).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium;
OC Fusarium oxysporum species complex.
OX NCBI_TaxID=5507 {ECO:0000313|EMBL:SCO79268.1, ECO:0000313|Proteomes:UP000219369};
RN [1] {ECO:0000313|Proteomes:UP000219369}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=V64-1 {ECO:0000313|Proteomes:UP000219369};
RA Guldener U.;
RL Submitted (SEP-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:SCO79268.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=V64-1 {ECO:0000313|EMBL:SCO79268.1};
RA Capua I., De Benedictis P., Joannis T., Lombin L.H., Cattoli G.;
RL Submitted (SEP-2016) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:RKK86628.1, ECO:0000313|Proteomes:UP000285084}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Fo_A13 {ECO:0000313|EMBL:RKK86628.1,
RC ECO:0000313|Proteomes:UP000285084};
RX PubMed=30202022; DOI=10.1038/s41598-018-30335-7;
RA Armitage A.D., Taylor A., Sobczyk M.K., Baxter L., Greenfield B.P.,
RA Bates H.J., Wilson F., Jackson A.C., Ott S., Harrison R.J., Clarkson J.P.;
RT "Characterisation of pathogen-specific regions and novel effector
RT candidates in Fusarium oxysporum f. sp. cepae.";
RL Sci. Rep. 8:13530-13530(2018).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-methionine = 3 H(+)
CC + N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:60292, Rhea:RHEA-COMP:15535, Rhea:RHEA-
CC COMP:15548, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856,
CC ChEBI:CHEBI:59789, ChEBI:CHEBI:61961; EC=2.1.1.356;
CC Evidence={ECO:0000256|ARBA:ARBA00000090};
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DR EMBL; MRCX01000004; RKK86628.1; -; Genomic_DNA.
DR EMBL; FMJY01000002; SCO79268.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2H3SS26; -.
DR VEuPathDB; FungiDB:FOC1_g10016174; -.
DR VEuPathDB; FungiDB:FOC4_g10014599; -.
DR VEuPathDB; FungiDB:FOIG_01414; -.
DR VEuPathDB; FungiDB:FOMG_01627; -.
DR VEuPathDB; FungiDB:FOXG_17467; -.
DR VEuPathDB; FungiDB:FOZG_01617; -.
DR VEuPathDB; FungiDB:HZS61_001237; -.
DR OrthoDB; 902834at2759; -.
DR Proteomes; UP000219369; Unassembled WGS sequence.
DR Proteomes; UP000285084; Unassembled WGS sequence.
DR GO; GO:0140951; F:histone H3K27 trimethyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR Gene3D; 2.170.270.10; SET domain; 1.
DR InterPro; IPR026489; CXC_dom.
DR InterPro; IPR045318; EZH1/2-like.
DR InterPro; IPR048360; Ezh2-like_CXC_fung.
DR InterPro; IPR040968; Ezh2_MCSS_fung.
DR InterPro; IPR040595; EZH2_N.
DR InterPro; IPR041355; Pre-SET_CXC.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR PANTHER; PTHR45747; HISTONE-LYSINE N-METHYLTRANSFERASE E(Z); 1.
DR PANTHER; PTHR45747:SF4; HISTONE-LYSINE N-METHYLTRANSFERASE E(Z); 1.
DR Pfam; PF21509; Ezh2-like__CXC_fung; 1.
DR Pfam; PF18600; Ezh2_MCSS_fung; 1.
DR Pfam; PF18601; EZH2_N; 1.
DR Pfam; PF18264; preSET_CXC; 1.
DR Pfam; PF00856; SET; 1.
DR SMART; SM00317; SET; 1.
DR SUPFAM; SSF82199; SET domain; 1.
DR PROSITE; PS51633; CXC; 1.
DR PROSITE; PS50280; SET; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 605..722
FT /note="CXC"
FT /evidence="ECO:0000259|PROSITE:PS51633"
FT DOMAIN 737..866
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT REGION 14..99
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 117..160
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 362..386
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 880..1054
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1084..1143
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 32..89
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 117..154
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 367..386
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 880..906
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 979..993
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1084..1098
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1112..1134
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1143 AA; 128303 MW; 4AE309D7CCC62E4B CRC64;
MASPHLVAIV AGKPDTIDLT GDSDSDYEPH SLVPLNRNNT TTARFTPNFS ISSERPSSTN
APVSPPKLNR STSSIAASQD KQPSASAEPP RPASSVLKLS QKVTTITANS DDAQSMAKLS
SVTASNLASR QVTPTPEKDA SKSTQQTKPA SPKYQTPKKQ EWDVAAIAEK LTQFRQDIKD
GHSRMTSYII ESTKPNERRV LTGKNLFAGL TNKPVPSKKG ETMRIKSKEH TKLKNNKRED
HYSIVRIQTD EERVPRYRFH HVEIKKNILT PNTMLTFVPH LRDLETSEEY KYNVWLQELE
DIDRKSGFKP MSREEKVRIA VRSEFASTVL LYLGTWLDKL SLPGCNRSAL IRYMASREPD
DAITPRQKSD ILNSHRPAES TTPPEANKAA NMFTEAFRRV FHQGQPPTKQ IELRDVLLLD
ESVDSIMETK PTAKDGSSTQ HENEHDAVEY WLGTYSILGC LICFSHSCEH GEYDAQNCKR
TLSILPRLSD TLKRRRRLPY SAADTVNGNG PLSPLCKRNC YRSSPRPVAA SIQRPWDEED
HFILRSTVAT ADRSKVTKDP FCLVAQLLDR DCSDVFNEYQ KLNVSMSPVE PANRLQIRTV
SWYDRFKKTL IGDWESHTKT HEHQKRELSE PCNHEGPCTS ESCICVQHGV LCEKFCGCTV
ENCAYKFTGC ACHSQGKTCL SKGKERPCIC VQLNRECDPD VCGRCGVVER ADPENADNEV
LHSTGCQNCS LQRGQAKSLA LGESQLEGVG YGLFTIEDIA QDDFIIEYVG ELITHDEGVR
REARRGDVFD EESNISYVFT LLDNEGIWVD AATYGNLSRY INHASESDKR GCNITPRILY
VNGEYRIKFT AMRDIKAGEE LFFNYGENFP NLTKKLLDHK VGGKSDQGKK RSRRPNGEGV
ARKNPKTDKK KPGKGKKRAQ AVLDEDDMLA DTLGFAPKPL RKRKKGPFEE DSEEEEYHPT
GTDASIMETP SDGDSDFGNS AARLRKRARQ DGKGAASSHN GKPRGDLKTR GKRGGARPGS
GRPRKYPRKL TSAPMLEHPS ASESQDREDP EERQIVAADT IVPAALQRPQ PVEINDSMEY
ITFSEERTEE SRLLQSQLEE DNDEDDDDDD QDVVVRSRVD RGVRNRRPTA KLRDDGDWIS
GSQ
//
