ID A0A2H3SVK3_FUSOX Unreviewed; 1094 AA.
AC A0A2H3SVK3;
DT 31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT 31-JAN-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=ATP-dependent RNA helicase mtr4 {ECO:0000313|EMBL:RKK78240.1};
DE SubName: Full=Probable ATP dependent RNA helicase {ECO:0000313|EMBL:SCO80442.1};
GN ORFNames=BFJ69_g5741 {ECO:0000313|EMBL:RKK78240.1}, FRV6_04655
GN {ECO:0000313|EMBL:SCO80442.1};
OS Fusarium oxysporum (Fusarium vascular wilt).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium;
OC Fusarium oxysporum species complex.
OX NCBI_TaxID=5507 {ECO:0000313|EMBL:SCO80442.1, ECO:0000313|Proteomes:UP000219369};
RN [1] {ECO:0000313|EMBL:SCO80442.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=V64-1 {ECO:0000313|EMBL:SCO80442.1};
RA Capua I., De Benedictis P., Joannis T., Lombin L.H., Cattoli G.;
RL Submitted (SEP-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000219369}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=V64-1 {ECO:0000313|Proteomes:UP000219369};
RA Guldener U.;
RL Submitted (SEP-2016) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:RKK78240.1, ECO:0000313|Proteomes:UP000285084}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Fo_A13 {ECO:0000313|EMBL:RKK78240.1,
RC ECO:0000313|Proteomes:UP000285084};
RX PubMed=30202022; DOI=10.1038/s41598-018-30335-7;
RA Armitage A.D., Taylor A., Sobczyk M.K., Baxter L., Greenfield B.P.,
RA Bates H.J., Wilson F., Jackson A.C., Ott S., Harrison R.J., Clarkson J.P.;
RT "Characterisation of pathogen-specific regions and novel effector
RT candidates in Fusarium oxysporum f. sp. cepae.";
RL Sci. Rep. 8:13530-13530(2018).
CC -!- SIMILARITY: Belongs to the helicase family. SKI2 subfamily.
CC {ECO:0000256|ARBA:ARBA00010140}.
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DR EMBL; MRCX01000040; RKK78240.1; -; Genomic_DNA.
DR EMBL; FMJY01000002; SCO80442.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2H3SVK3; -.
DR VEuPathDB; FungiDB:FOC1_g10013323; -.
DR VEuPathDB; FungiDB:FOC4_g10007401; -.
DR VEuPathDB; FungiDB:FOIG_00118; -.
DR VEuPathDB; FungiDB:FOMG_00282; -.
DR VEuPathDB; FungiDB:FOXG_11049; -.
DR VEuPathDB; FungiDB:FOZG_00292; -.
DR VEuPathDB; FungiDB:HZS61_000152; -.
DR OrthoDB; 1352at2759; -.
DR Proteomes; UP000219369; Unassembled WGS sequence.
DR Proteomes; UP000285084; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:InterPro.
DR GO; GO:0006401; P:RNA catabolic process; IEA:InterPro.
DR CDD; cd18024; DEXHc_Mtr4-like; 1.
DR CDD; cd13154; KOW_Mtr4; 1.
DR CDD; cd18795; SF2_C_Ski2; 1.
DR Gene3D; 1.10.3380.30; -; 1.
DR Gene3D; 2.40.30.300; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR048392; MTR4-like_stalk.
DR InterPro; IPR025696; MTR4_beta-barrel.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR016438; SKI2-like.
DR InterPro; IPR012961; Ski2/MTR4_C.
DR PANTHER; PTHR12131; ATP-DEPENDENT RNA AND DNA HELICASE; 1.
DR PANTHER; PTHR12131:SF7; EXOSOME RNA HELICASE MTR4; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF08148; DSHCT; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF21408; MTR4-like_stalk; 1.
DR Pfam; PF13234; MTR4_beta-barrel; 1.
DR PIRSF; PIRSF005198; Antiviral_helicase_SKI2; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM01142; DSHCT; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000313|EMBL:SCO80442.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242}.
FT DOMAIN 166..322
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 402..606
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1..92
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 369..400
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..36
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 47..63
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 74..90
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 369..395
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1094 AA; 124045 MW; 5939F72CBE1579A1 CRC64;
MDEMFDVFEG KVDAPSASED ENVPNRKGDT KKRKANAING ENGNAAKTED VDMDAKTESS
KDGDSSDDEE SSESASQQES KRRKKEDGVG PVMTDTFQTA ESREVAGAAT FTEQDSSLVL
SHNIQHQVAL PPDLDYEYVP LSEHKAPEQP ARTWNFKLDP FQSLSVASIE REESVLVSAH
TSAGKTVVAE YAVAQCLKRN QRVIYTSPIK ALSNQKYRDF EAIFGDVGLM TGDVTINPTA
SCLVMTTEIL RSMLYRGSEI MREVAWVVFD EIHYMRDKIR GVVWEETIIM LPDKVRYVFL
SATIPNAFQF AEWIAKIHHQ ACHVVYTDFR PTPLQNYFFP SGGTGARLIV DEKSNFNEQN
FNKVMQEVEE KKGADPNDPN ARQKGKGKNK KTNKGGADSG SDISKIIRMT IKKKFNPVIV
FNFSKRECEN LAMNISSLSF NDDSEKAMVR KVFNSAIESL SEGDRELPQI INLLPLLERG
IGVHHSGLLP ILKETIEILF QESLIKVLFA TETFSIGLNM PAKTVVFTQV TKWDGVKRRP
LTSSEYIQMA GRAGRRGLDA RGIVIMMIDD KLEPDTAKEI VTGHQDRLNS AFYLGYNMIL
NLLRIEAISP EFMLERCFHQ FQNAASVPSL EKELMSLQQE RDNTSIADES TVKDYYQIRQ
QLSAYTKDMR TVIQHPNYSI SYLQPGRLVQ IYNPKDENET IAGTGTDFGW GVIVNQTPRR
APKMGEPEYA PQESYVIDVL LPISRSSADF YPTQPVEDTP MPVGLKPFGD DDDIKFAIVP
CLLTCIKAIS QIRLFLPKEG LKSESEKETL TKSLMEVKRR FPDGLPVLDP IENMEITDDS
FKKLLRKIEV LESRLLANPL HLSPLLPALW DQYHTKVKLT EKVKETKKAI AKAYSIAQMD
ELKSRKRVLR RLGFINDSEV VQLKARVACE ISSTEGHELL LSELLFDRFF NELTPEMCAA
VMSCFIFDEK IETTQLKEEL SKPYREIQAK ARIIAKVSQE CKLEVNEEEY VQKLKWQLME
TVYAWAQGRP FIEICKMTKV YEGSLIRLFR RLEELLRQMG QAAKVMGNDD LTKKFEDSLS
KIRRDIVAAQ SLYL
//
