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Database: UniProt
Entry: A0A2H3T3A4_FUSOX
LinkDB: A0A2H3T3A4_FUSOX
Original site: A0A2H3T3A4_FUSOX 
ID   A0A2H3T3A4_FUSOX        Unreviewed;       201 AA.
AC   A0A2H3T3A4;
DT   31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT   31-JAN-2018, sequence version 1.
DT   22-FEB-2023, entry version 13.
DE   RecName: Full=Dihydrofolate reductase {ECO:0000256|ARBA:ARBA00018886};
DE            EC=1.5.1.3 {ECO:0000256|ARBA:ARBA00012856};
GN   ORFNames=FRV6_07355 {ECO:0000313|EMBL:SCO83142.1};
OS   Fusarium oxysporum (Fusarium vascular wilt).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium;
OC   Fusarium oxysporum species complex.
OX   NCBI_TaxID=5507 {ECO:0000313|EMBL:SCO83142.1, ECO:0000313|Proteomes:UP000219369};
RN   [1] {ECO:0000313|Proteomes:UP000219369}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=V64-1 {ECO:0000313|Proteomes:UP000219369};
RA   Guldener U.;
RL   Submitted (SEP-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- PATHWAY: Cofactor biosynthesis; tetrahydrofolate biosynthesis; 5,6,7,8-
CC       tetrahydrofolate from 7,8-dihydrofolate: step 1/1.
CC       {ECO:0000256|ARBA:ARBA00004903}.
CC   -!- SIMILARITY: Belongs to the dihydrofolate reductase family.
CC       {ECO:0000256|RuleBase:RU004474}.
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DR   EMBL; FMJY01000004; SCO83142.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2H3T3A4; -.
DR   VEuPathDB; FungiDB:FOC1_g10013563; -.
DR   VEuPathDB; FungiDB:FOC4_g10010544; -.
DR   VEuPathDB; FungiDB:FOIG_05606; -.
DR   VEuPathDB; FungiDB:FOMG_04862; -.
DR   VEuPathDB; FungiDB:FOXG_02192; -.
DR   VEuPathDB; FungiDB:FOZG_05034; -.
DR   VEuPathDB; FungiDB:HZS61_010091; -.
DR   OrthoDB; 1118873at2759; -.
DR   UniPathway; UPA00077; UER00158.
DR   Proteomes; UP000219369; Unassembled WGS sequence.
DR   GO; GO:0004146; F:dihydrofolate reductase activity; IEA:UniProtKB-EC.
DR   GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR   GO; GO:0006545; P:glycine biosynthetic process; IEA:InterPro.
DR   GO; GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0046654; P:tetrahydrofolate biosynthetic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd00209; DHFR; 1.
DR   Gene3D; 3.40.430.10; Dihydrofolate Reductase, subunit A; 1.
DR   InterPro; IPR012259; DHFR.
DR   InterPro; IPR024072; DHFR-like_dom_sf.
DR   InterPro; IPR017925; DHFR_CS.
DR   InterPro; IPR001796; DHFR_dom.
DR   PANTHER; PTHR48069; DIHYDROFOLATE REDUCTASE; 1.
DR   PANTHER; PTHR48069:SF3; DIHYDROFOLATE REDUCTASE; 1.
DR   Pfam; PF00186; DHFR_1; 1.
DR   PRINTS; PR00070; DHFR.
DR   SUPFAM; SSF53597; Dihydrofolate reductase-like; 1.
DR   PROSITE; PS00075; DHFR_1; 1.
DR   PROSITE; PS51330; DHFR_2; 1.
PE   3: Inferred from homology;
KW   NADP {ECO:0000256|ARBA:ARBA00022857};
KW   One-carbon metabolism {ECO:0000256|ARBA:ARBA00022563};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002}.
FT   DOMAIN          5..199
FT                   /note="DHFR"
FT                   /evidence="ECO:0000259|PROSITE:PS51330"
SQ   SEQUENCE   201 AA;  22877 MW;  F3E3BF1620DD5B25 CRC64;
     MQSLELNLIV AATRNMGIGL HGTMPWQGLR KEMKYFARVT TRVPPQASSS SINAVIMGRK
     TWDSIPTKFR PLKDRLNIVI SRSAPSKLPG KVEPSEPVRV QSLELALQYA RAHSDVGRIF
     VIGGAQIYDA ALRLPEARRI LLTSIERDFD CDTFFPVDLK DGSWERKSRE ELQEWTGEEI
     EEGGQEEAGT KYEFQMWEKH D
//
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