ID   A0A2H3T8E2_FUSOX        Unreviewed;       858 AA.
AC   A0A2H3T8E2;
DT   31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT   31-JAN-2018, sequence version 1.
DT   27-MAR-2024, entry version 18.
DE   SubName: Full=Related to A.thaliana hyp1 protein {ECO:0000313|EMBL:SCO85008.1};
GN   ORFNames=FRV6_09135 {ECO:0000313|EMBL:SCO85008.1};
OS   Fusarium oxysporum (Fusarium vascular wilt).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium;
OC   Fusarium oxysporum species complex.
OX   NCBI_TaxID=5507 {ECO:0000313|EMBL:SCO85008.1, ECO:0000313|Proteomes:UP000219369};
RN   [1] {ECO:0000313|Proteomes:UP000219369}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=V64-1 {ECO:0000313|Proteomes:UP000219369};
RA   Guldener U.;
RL   Submitted (SEP-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the CSC1 (TC 1.A.17) family.
CC       {ECO:0000256|ARBA:ARBA00007779}.
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DR   EMBL; FMJY01000005; SCO85008.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2H3T8E2; -.
DR   VEuPathDB; FungiDB:FOC1_h10016686; -.
DR   VEuPathDB; FungiDB:FOC4_h10017501; -.
DR   VEuPathDB; FungiDB:FOIG_08291; -.
DR   VEuPathDB; FungiDB:FOMG_12304; -.
DR   VEuPathDB; FungiDB:FOXG_08369; -.
DR   VEuPathDB; FungiDB:FOZG_06875; -.
DR   VEuPathDB; FungiDB:HZS61_012769; -.
DR   OrthoDB; 366603at2759; -.
DR   Proteomes; UP000219369; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005227; F:calcium-activated cation channel activity; IEA:InterPro.
DR   InterPro; IPR045122; Csc1-like.
DR   InterPro; IPR003864; CSC1/OSCA1-like_7TM.
DR   InterPro; IPR027815; CSC1/OSCA1-like_cyt.
DR   InterPro; IPR032880; Csc1/OSCA1-like_N.
DR   PANTHER; PTHR13018:SF83; CALCIUM PERMEABLE STRESS-GATED CATION CHANNEL 1; 1.
DR   PANTHER; PTHR13018; PROBABLE MEMBRANE PROTEIN DUF221-RELATED; 1.
DR   Pfam; PF14703; PHM7_cyt; 1.
DR   Pfam; PF02714; RSN1_7TM; 1.
DR   Pfam; PF13967; RSN1_TM; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   TRANSMEM        26..47
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        104..122
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        179..199
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        436..462
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        482..509
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        530..551
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        577..604
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        652..669
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        690..710
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        716..735
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          24..197
FT                   /note="CSC1/OSCA1-like N-terminal transmembrane"
FT                   /evidence="ECO:0000259|Pfam:PF13967"
FT   DOMAIN          220..423
FT                   /note="CSC1/OSCA1-like cytosolic"
FT                   /evidence="ECO:0000259|Pfam:PF14703"
FT   DOMAIN          434..708
FT                   /note="CSC1/OSCA1-like 7TM region"
FT                   /evidence="ECO:0000259|Pfam:PF02714"
FT   REGION          288..339
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        302..317
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   858 AA;  97799 MW;  041CE36D0C15E36A CRC64;
     MKNKTDSCWD EKIIDPDTGK SLEVQLVLSL VIGVSAFFLF CFLRPRWPAL YAARKRRLDH
     QLGLPALPNS TFGWIPTLFK ITEEQVLASA GLDAFVFLSF FKMAIRLFSI MAFFATVILL
     PINRSFSDTK SKKGHGGDDT STVPGSFYGT DQNVFSDASF LDILKHKDKT DKSYEKSWLW
     AYVIFTYFFV GLTIYYLNLE TFRVIKFRQD YLGSQSTVTD RTFRLTGIPE DLRSEEKIKD
     LIEKLGVGKV EKVMLCRDWK KLDDLVELRD ATLRRLEGAW ATFLQHQRRK RKSAGHQRRR
     GNGVSQEQED DDQTGENGRL LDSQQEPWDS GDEGRPKVNI RYGTLGLRSR NVDAIDYYEE
     RLRRLDAQVI EARKKTYAPT DMAIVTMDSV ASCQMAIQAR IDPRPGRLLT KLTPAPSDLV
     WRNTYAPRGI RRLKSWAVTL FITALTLAFI FPTIAISSLL SYCTIESNFK PFAKWLQAHG
     VIFSLVQNGL PALVVSLLNV AVPYLYDFLS NHQGMISQGD VELSVISKNY FFTFFNTFFV
     FAVSLSGINF WSRLQDFAKD TSKMPRAIAG DVEKLSIFYI CFIMLQGIGL MPFRILEAGS
     VFLYPFLRWL SKTPRDALEL KKPPVFQYGF FLPTSLLVFN LCLIYSVLAW GYAILIVGTV
     YFCLGYFAFK YMVLYAMDQP QHATGGAWRI ISYRIIVGLL VLEVVMVGRI ATSEAFIQSV
     CILPLLPFTI WYSYYIKQRF EPLTKYIALR AVRADEDPDD AAALDDAFEN EDRPRPSQAI
     LRRGSTLDEY KEKGLQFVNP SLVAPLPQPW IYDEPPPPIP MDDTQTTEET ERPVLQGVDS
     TLGIGDENVW RDNGGNNV
//