ID A0A2H3THK5_FUSOX Unreviewed; 1683 AA.
AC A0A2H3THK5;
DT 31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT 31-JAN-2018, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE RecName: Full=Clathrin heavy chain {ECO:0000256|PIRNR:PIRNR002290};
GN ORFNames=BFJ68_g12 {ECO:0000313|EMBL:RKL25368.1}, BFJ69_g5170
GN {ECO:0000313|EMBL:RKK78940.1}, BFJ71_g10544
GN {ECO:0000313|EMBL:RKK91883.1}, FOXYS1_6582
GN {ECO:0000313|EMBL:KAF5262701.1}, FRV6_12270
GN {ECO:0000313|EMBL:SCO88143.1};
OS Fusarium oxysporum (Fusarium vascular wilt).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium;
OC Fusarium oxysporum species complex.
OX NCBI_TaxID=5507 {ECO:0000313|EMBL:SCO88143.1, ECO:0000313|Proteomes:UP000219369};
RN [1] {ECO:0000313|Proteomes:UP000219369}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=V64-1 {ECO:0000313|Proteomes:UP000219369};
RA Guldener U.;
RL Submitted (SEP-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:SCO88143.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=V64-1 {ECO:0000313|EMBL:SCO88143.1};
RA Capua I., De Benedictis P., Joannis T., Lombin L.H., Cattoli G.;
RL Submitted (SEP-2016) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Proteomes:UP000285084, ECO:0000313|Proteomes:UP000285237}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Fo_A13 {ECO:0000313|EMBL:RKK78940.1,
RC ECO:0000313|Proteomes:UP000285084}, Fo_A28
RC {ECO:0000313|EMBL:RKL25368.1, ECO:0000313|Proteomes:UP000285860}, and
RC Fo_CB3 {ECO:0000313|EMBL:RKK91883.1,
RC ECO:0000313|Proteomes:UP000285237};
RX PubMed=30202022; DOI=10.1038/s41598-018-30335-7;
RA Armitage A.D., Taylor A., Sobczyk M.K., Baxter L., Greenfield B.P.,
RA Bates H.J., Wilson F., Jackson A.C., Ott S., Harrison R.J., Clarkson J.P.;
RT "Characterisation of pathogen-specific regions and novel effector
RT candidates in Fusarium oxysporum f. sp. cepae.";
RL Sci. Rep. 8:13530-13530(2018).
RN [4] {ECO:0000313|EMBL:KAF5262701.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL 39464 {ECO:0000313|EMBL:KAF5262701.1};
RA Kim H.-S., Busman M., Brown D.W., Divon H., Uhlig S., Proctor R.H.;
RT "Identification and distribution of gene clusters putatively required for
RT synthesis of sphingolipid metabolism inhibitors in phylogenetically diverse
RT species of the filamentous fungus Fusarium.";
RL Submitted (FEB-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Clathrin is the major protein of the polyhedral coat of
CC coated pits and vesicles. {ECO:0000256|PIRNR:PIRNR002290}.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane
CC {ECO:0000256|PIRNR:PIRNR002290}; Peripheral membrane protein
CC {ECO:0000256|PIRNR:PIRNR002290}; Cytoplasmic side
CC {ECO:0000256|PIRNR:PIRNR002290}. Membrane, coated pit
CC {ECO:0000256|PIRNR:PIRNR002290}; Peripheral membrane protein
CC {ECO:0000256|PIRNR:PIRNR002290}; Cytoplasmic side
CC {ECO:0000256|PIRNR:PIRNR002290}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
CC -!- SIMILARITY: Belongs to the clathrin heavy chain family.
CC {ECO:0000256|PIRNR:PIRNR002290}.
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DR EMBL; JAAFOW010001040; KAF5262701.1; -; Genomic_DNA.
DR EMBL; MRCX01000035; RKK78940.1; -; Genomic_DNA.
DR EMBL; MRCZ01000077; RKK91883.1; -; Genomic_DNA.
DR EMBL; MRCY01000001; RKL25368.1; -; Genomic_DNA.
DR EMBL; FMJY01000007; SCO88143.1; -; Genomic_DNA.
DR VEuPathDB; FungiDB:FOC1_g10012544; -.
DR VEuPathDB; FungiDB:FOC4_g10008526; -.
DR VEuPathDB; FungiDB:FOIG_05043; -.
DR VEuPathDB; FungiDB:FOMG_08086; -.
DR VEuPathDB; FungiDB:FOXG_09267; -.
DR VEuPathDB; FungiDB:FOZG_12550; -.
DR VEuPathDB; FungiDB:HZS61_017299; -.
DR OrthoDB; 5474327at2759; -.
DR Proteomes; UP000219369; Unassembled WGS sequence.
DR Proteomes; UP000285084; Unassembled WGS sequence.
DR Proteomes; UP000285237; Unassembled WGS sequence.
DR Proteomes; UP000285860; Unassembled WGS sequence.
DR Proteomes; UP000558688; Unassembled WGS sequence.
DR GO; GO:0030132; C:clathrin coat of coated pit; IEA:InterPro.
DR GO; GO:0030130; C:clathrin coat of trans-Golgi network vesicle; IEA:InterPro.
DR GO; GO:0071439; C:clathrin complex; IEA:InterPro.
DR GO; GO:0032051; F:clathrin light chain binding; IEA:InterPro.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:UniProtKB-UniRule.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR Gene3D; 1.25.40.730; -; 1.
DR Gene3D; 2.130.10.110; Clathrin heavy-chain terminal domain; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 3.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000547; Clathrin_H-chain/VPS_repeat.
DR InterPro; IPR016025; Clathrin_H-chain_N.
DR InterPro; IPR022365; Clathrin_H-chain_propeller_rpt.
DR InterPro; IPR016341; Clathrin_heavy_chain.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR10292:SF1; CLATHRIN HEAVY CHAIN; 1.
DR PANTHER; PTHR10292; CLATHRIN HEAVY CHAIN RELATED; 1.
DR Pfam; PF00637; Clathrin; 7.
DR Pfam; PF13838; Clathrin_H_link; 1.
DR Pfam; PF01394; Clathrin_propel; 3.
DR PIRSF; PIRSF002290; Clathrin_H_chain; 1.
DR SMART; SM00299; CLH; 7.
DR SUPFAM; SSF48371; ARM repeat; 6.
DR SUPFAM; SSF50989; Clathrin heavy-chain terminal domain; 1.
DR PROSITE; PS50236; CHCR; 7.
PE 3: Inferred from homology;
KW Coated pit {ECO:0000256|PIRNR:PIRNR002290};
KW Cytoplasmic vesicle {ECO:0000256|PIRNR:PIRNR002290};
KW Membrane {ECO:0000256|PIRNR:PIRNR002290};
KW Reference proteome {ECO:0000313|Proteomes:UP000558688}.
FT REPEAT 541..690
FT /note="CHCR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01006"
FT REPEAT 693..835
FT /note="CHCR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01006"
FT REPEAT 841..980
FT /note="CHCR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01006"
FT REPEAT 987..1132
FT /note="CHCR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01006"
FT REPEAT 1136..1277
FT /note="CHCR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01006"
FT REPEAT 1282..1428
FT /note="CHCR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01006"
FT REPEAT 1431..1574
FT /note="CHCR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01006"
FT REGION 1659..1683
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1683 AA; 190605 MW; 29435346A2FC663C CRC64;
MPTLPIKFQE LVQLANVGVD TQSIGFNSCT LESDSYVCVR EKKNEAAQPE VVIIELKNGN
NVTRRPIKAD SAIMHWNRQV IALKAQSRTL QIFDLEQKKK LKSCTMNEDV QFWKWISENE
LGLVTTTSVF HWNVYDAGQD APVKVFQRND NLQGCQIINY RVNSDGKWMV VVGISSQQGR
VVGAMQLYSK DRGISQAIEG HAAAFGTLRL EGAPQDTKFF SFAVRTATGA KLHIVEVDHP
ESNPVFQKKA VDMFFPPEAT NDFPVALQVS QKYGVIYMVT KYGFIHLYDL ETASCIYMNR
ISSETIFTTC TDDGSSGIVG INRKGQVLFV TIDDNNIIPY LLQNPANSEM AIKMASRAGL
PGADNLYARQ FEQLFNAGSY LEAAKVAANS PRGFLRSAET IEKFKRLPVQ PGQMAFTLQY
FGMLLDKGAL NREETLELAQ PVLQQNRKHL LEKWLKEGKL DCSEALGDLV RPYDMNMALT
IYLKAEVPAK VVAGFAETGQ FDKILPYSAQ TGYQPDYIQL LQHIIRINPE KGAEFASALA
NNEQGSLVDL ERVCDIFQGQ GMIQQATAFL LDALKENKPE HARLQTRLLE MNLMHAPQVA
EAILGNEMFT HFDKSRIAQL CEQANLPQKA LELYEDPEAI KRVIVNIPGS PNFNPDWLTT
FFGKLSVEQS LDCLDAMMKT NIRQNLQSVV TIATKYSDLL GAVRLIDLFE KYKTAEGLFY
YLGSIVNLSE DPDVHFKYIE AATKMGQFNE VERLCRDSNV YNPEKVKNFL KEAKLPEQLP
LIIVCDRFNF VHDLILYLYQ NQQFAAIETY VQSVNPTRAP EVIGGLLDVD CDENVIKQLL
QTVNAQAISI DSLVSEVESR NRLKLLLPFL EKTLNEGNQQ QAVFNALAKI YIDSNNNPEK
FLKENDQYDT LTVGKYCEKR DPNLAYIAYS KGQNDLELVN ITNENSMYRA QARYLLERSD
AELWGFVLSE NNIHRRSVVD QVTATAVPEA NDPSKVSVAV AAFLENDLPL ELIELLEKIV
LEPSPFSDNQ NLQNLLMFTA AKADKGRVMD YIHKLDNYNA DEIATACIEV GLFEEAFEIY
KKADNKSAAV DVLIENVVSI DRAQGYAEEV DLPEVWSKVA KAQLDGLRVS DAIESYIKAE
DPRNYLEVIE VATHAGKNED LVKYLRMCRK TLREPAIDTA LAFSYARLDQ LSELEDFLRA
TNVANIEESG DKAYEEGLFE ASKIFYTSIS NWAKLATTLV HLGDYQAAVE CARKANNIKV
WKQVHEACVQ KKEFRLAQIC GLNLIVDAEQ LQTLVKEYER NGYFDELISL LEQGLGLERA
HMGMFTELGI ALSKYHPDRL MEHIKIFWSR MNLPKMIKAC EEANLWPELV FCYYHYDEFD
NAALAVIERP ENSWDHQQFK EIVVKVANLE IYYRAIKFYV EQHPSLITDL LATLTPRIDV
NRVVKIFQKN DDLPLIKPFL LNVQTQNKRV VNEAVNDLLI EEEDYKTLRD SVQNYDNYDA
TELASRLEKH DLIFFRQIAA SIYRKNKRWE KSIALSKQDK LYKDAIETAA LSAKTEIVSD
LLQYFVDIGH RECYTGMLYA CYELIRPDLV LELSWRHGLM DFSMPYMINM LAQQTKDLAL
LKADNEARKA KEQEKEKTDD NTPILGASRL MITAGPGGMG SSPSPAPYGQ ANGFAPQPTG
YGF
//