ID   A0A2H3TUL8_FUSOX        Unreviewed;       406 AA.
AC   A0A2H3TUL8;
DT   31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT   31-JAN-2018, sequence version 1.
DT   27-MAR-2024, entry version 20.
DE   SubName: Full=Related to extracellular metalloproteinase {ECO:0000313|EMBL:SCO92308.1};
GN   ORFNames=FRV6_16436 {ECO:0000313|EMBL:SCO92308.1};
OS   Fusarium oxysporum (Fusarium vascular wilt).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium;
OC   Fusarium oxysporum species complex.
OX   NCBI_TaxID=5507 {ECO:0000313|EMBL:SCO92308.1, ECO:0000313|Proteomes:UP000219369};
RN   [1] {ECO:0000313|Proteomes:UP000219369}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=V64-1 {ECO:0000313|Proteomes:UP000219369};
RA   Guldener U.;
RL   Submitted (SEP-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the peptidase M4 family.
CC       {ECO:0000256|ARBA:ARBA00009388}.
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DR   EMBL; FMJY01000010; SCO92308.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2H3TUL8; -.
DR   VEuPathDB; FungiDB:FOC1_g10011973; -.
DR   VEuPathDB; FungiDB:FOIG_06178; -.
DR   VEuPathDB; FungiDB:FOMG_08876; -.
DR   VEuPathDB; FungiDB:FOXG_05949; -.
DR   VEuPathDB; FungiDB:FOZG_07649; -.
DR   VEuPathDB; FungiDB:HZS61_013531; -.
DR   OrthoDB; 2679274at2759; -.
DR   Proteomes; UP000219369; Unassembled WGS sequence.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd09597; M4_TLP; 1.
DR   Gene3D; 3.10.170.10; -; 1.
DR   Gene3D; 1.10.390.10; Neutral Protease Domain 2; 1.
DR   InterPro; IPR023612; Peptidase_M4.
DR   InterPro; IPR027268; Peptidase_M4/M1_CTD_sf.
DR   InterPro; IPR001570; Peptidase_M4_C_domain.
DR   InterPro; IPR013856; Peptidase_M4_domain.
DR   InterPro; IPR032475; Protealysin_N_PP.
DR   PANTHER; PTHR43579; -; 1.
DR   PANTHER; PTHR43579:SF1; NEUTRAL METALLOPROTEINASE; 1.
DR   Pfam; PF01447; Peptidase_M4; 1.
DR   Pfam; PF02868; Peptidase_M4_C; 1.
DR   Pfam; PF16485; PLN_propep; 1.
DR   PRINTS; PR00730; THERMOLYSIN.
DR   SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Protease {ECO:0000256|ARBA:ARBA00022670};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT   DOMAIN          60..99
FT                   /note="Protealysin N-terminal propeptide"
FT                   /evidence="ECO:0000259|Pfam:PF16485"
FT   DOMAIN          97..232
FT                   /note="Peptidase M4"
FT                   /evidence="ECO:0000259|Pfam:PF01447"
FT   DOMAIN          236..402
FT                   /note="Peptidase M4 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF02868"
FT   REGION          98..140
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        116..140
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   406 AA;  45235 MW;  37C088AA907E04F6 CRC64;
     MACRHFIVPP HLLRAIADSE ANADKIRHAA RRTLAARDTY TKVRAERMVA LTVPRGYQRQ
     QIIPPHILRS LSQSEESEEN VRDRAKRDLQ HVEGLMQQKL ASSESSGTAE LAKKPSPKRS
     VYDANHTTDE ADLPGKLVRK EGGDKVKDEA VNEAYDNVGI VLGFYKEQFN WNSIDNKNVD
     VSSSVHFGEG YENAFWDPER LQMVYGDGGE FLNNFTGCID VIGHELTHAV TEHTSPLEYT
     GQSGALNEHV SDVFGIMIKQ KVQNEKAHGA DWLIGEDCIL PGVKGVALRS MKAPGTAYDD
     ARFGKDPQPD NMKDYEIIVE DNGGVHIYSG IPNKAFYLAS VAFGGYSWEK AGKIWWETMR
     SGKIAPKCQF KHFADITVEI AEELFGEEAA KIVRKAWTDV GITRGI
//