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Database: UniProt
Entry: A0A2H3Z392_PHODC
LinkDB: A0A2H3Z392_PHODC
Original site: A0A2H3Z392_PHODC 
ID   A0A2H3Z392_PHODC        Unreviewed;       838 AA.
AC   A0A2H3Z392;
DT   31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT   31-JAN-2018, sequence version 1.
DT   31-JUL-2019, entry version 14.
DE   RecName: Full=Urease {ECO:0000256|PIRNR:PIRNR001222};
DE            EC=3.5.1.5 {ECO:0000256|PIRNR:PIRNR001222};
DE   AltName: Full=Urea amidohydrolase {ECO:0000256|PIRNR:PIRNR001222};
GN   Name=LOC103719873 {ECO:0000313|RefSeq:XP_008807555.1};
OS   Phoenix dactylifera (Date palm).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Arecaceae; Coryphoideae;
OC   Phoeniceae; Phoenix.
OX   NCBI_TaxID=42345 {ECO:0000313|Proteomes:UP000228380, ECO:0000313|RefSeq:XP_008807555.1};
RN   [1] {ECO:0000313|Proteomes:UP000228380}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Khalas {ECO:0000313|Proteomes:UP000228380};
RX   PubMed=23917264; DOI=10.1038/ncomms3274;
RA   Al-Mssallem I.S., Hu S., Zhang X., Lin Q., Liu W., Tan J., Yu X.,
RA   Liu J., Pan L., Zhang T., Yin Y., Xin C., Wu H., Zhang G.,
RA   Ba Abdullah M.M., Huang D., Fang Y., Alnakhli Y.O., Jia S., Yin A.,
RA   Alhuzimi E.M., Alsaihati B.A., Al-Owayyed S.A., Zhao D., Zhang S.,
RA   Al-Otaibi N.A., Sun G., Majrashi M.A., Li F., Tala, Wang J., Yun Q.,
RA   Alnassar N.A., Wang L., Yang M., Al-Jelaify R.F., Liu K., Gao S.,
RA   Chen K., Alkhaldi S.R., Liu G., Zhang M., Guo H., Yu J.;
RT   "Genome sequence of the date palm Phoenix dactylifera L.";
RL   Nat. Commun. 4:2274-2274(2013).
RN   [2] {ECO:0000313|RefSeq:XP_008807555.1}
RP   IDENTIFICATION.
RC   TISSUE=Bud {ECO:0000313|RefSeq:XP_008807555.1};
RG   RefSeq;
RL   Submitted (MAR-2019) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2 H(+) + H2O + urea = CO2 + 2 NH4(+);
CC         Xref=Rhea:RHEA:20557, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16199, ChEBI:CHEBI:16526, ChEBI:CHEBI:28938;
CC         EC=3.5.1.5; Evidence={ECO:0000256|PIRNR:PIRNR001222};
CC   -!- COFACTOR:
CC       Name=Ni cation; Xref=ChEBI:CHEBI:25516;
CC         Evidence={ECO:0000256|PIRNR:PIRNR001222,
CC         ECO:0000256|PIRSR:PIRSR001222-51};
CC       Note=Binds 2 nickel ions per subunit.
CC       {ECO:0000256|PIRNR:PIRNR001222, ECO:0000256|PIRSR:PIRSR001222-51};
CC   -!- PATHWAY: Nitrogen metabolism; urea degradation; CO(2) and NH(3)
CC       from urea (urease route): step 1/1.
CC       {ECO:0000256|PIRNR:PIRNR001222}.
CC   -!- PTM: Carbamylation allows a single lysine to coordinate two nickel
CC       ions. {ECO:0000256|PIRSR:PIRSR001222-50}.
CC   -!- SIMILARITY: In the C-terminal section; belongs to the metallo-
CC       dependent hydrolases superfamily. Urease alpha subunit family.
CC       {ECO:0000256|PIRNR:PIRNR001222}.
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DR   RefSeq; XP_008807555.1; XM_008809333.1.
DR   GeneID; 103719873; -.
DR   UniPathway; UPA00258; UER00370.
DR   Proteomes; UP000228380; Genome assembly.
DR   GO; GO:0016151; F:nickel cation binding; IEA:InterPro.
DR   GO; GO:0009039; F:urease activity; IEA:UniProtKB-EC.
DR   GO; GO:0043419; P:urea catabolic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd00375; Urease_alpha; 1.
DR   CDD; cd00407; Urease_beta; 1.
DR   CDD; cd00390; Urease_gamma; 1.
DR   Gene3D; 2.10.150.10; -; 1.
DR   Gene3D; 2.30.40.10; -; 1.
DR   Gene3D; 3.30.280.10; -; 1.
DR   HAMAP; MF_01953; Urease_alpha; 1.
DR   InterPro; IPR006680; Amidohydro-rel.
DR   InterPro; IPR011059; Metal-dep_hydrolase_composite.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   InterPro; IPR008221; Urease.
DR   InterPro; IPR011612; Urease_alpha_N_dom.
DR   InterPro; IPR017950; Urease_AS.
DR   InterPro; IPR005848; Urease_asu.
DR   InterPro; IPR017951; Urease_asu_c.
DR   InterPro; IPR002019; Urease_beta.
DR   InterPro; IPR036461; Urease_betasu_sf.
DR   InterPro; IPR002026; Urease_gamma/gamma-beta_su.
DR   InterPro; IPR036463; Urease_gamma_sf.
DR   InterPro; IPR040881; Urease_linker.
DR   InterPro; IPR029754; Urease_Ni-bd.
DR   Pfam; PF01979; Amidohydro_1; 1.
DR   Pfam; PF00449; Urease_alpha; 1.
DR   Pfam; PF00699; Urease_beta; 1.
DR   Pfam; PF00547; Urease_gamma; 1.
DR   Pfam; PF18473; Urease_linker; 1.
DR   PIRSF; PIRSF001222; Urease; 1.
DR   PRINTS; PR01752; UREASE.
DR   SUPFAM; SSF51278; SSF51278; 1.
DR   SUPFAM; SSF51338; SSF51338; 2.
DR   SUPFAM; SSF51556; SSF51556; 1.
DR   SUPFAM; SSF54111; SSF54111; 1.
DR   TIGRFAMs; TIGR01792; urease_alph; 1.
DR   TIGRFAMs; TIGR00192; urease_beta; 1.
DR   TIGRFAMs; TIGR00193; urease_gam; 1.
DR   PROSITE; PS01120; UREASE_1; 1.
DR   PROSITE; PS00145; UREASE_2; 1.
DR   PROSITE; PS51368; UREASE_3; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000228380};
KW   Hydrolase {ECO:0000256|PIRNR:PIRNR001222, ECO:0000256|PROSITE-
KW   ProRule:PRU00700};
KW   Metal-binding {ECO:0000256|PIRNR:PIRNR001222,
KW   ECO:0000256|PIRSR:PIRSR001222-51};
KW   Nickel {ECO:0000256|PIRNR:PIRNR001222, ECO:0000256|PIRSR:PIRSR001222-
KW   51}; Reference proteome {ECO:0000313|Proteomes:UP000228380}.
FT   DOMAIN      399    838       Urease. {ECO:0000259|PROSITE:PS51368}.
FT   ACT_SITE    590    590       Proton donor. {ECO:0000256|PIRSR:
FT                                PIRSR611612-52, ECO:0000256|PROSITE-
FT                                ProRule:PRU00700}.
FT   METAL       404    404       Nickel 1; via tele nitrogen.
FT                                {ECO:0000256|PIRSR:PIRSR001222-51}.
FT   METAL       406    406       Nickel 1; via tele nitrogen.
FT                                {ECO:0000256|PIRSR:PIRSR001222-51}.
FT   METAL       487    487       Nickel 1; via carbamate group.
FT                                {ECO:0000256|PIRSR:PIRSR001222-51}.
FT   METAL       487    487       Nickel 2; via carbamate group.
FT                                {ECO:0000256|PIRSR:PIRSR001222-51}.
FT   METAL       516    516       Nickel 2; via pros nitrogen.
FT                                {ECO:0000256|PIRSR:PIRSR001222-51}.
FT   METAL       542    542       Nickel 2; via tele nitrogen.
FT                                {ECO:0000256|PIRSR:PIRSR001222-51}.
FT   METAL       630    630       Nickel 1. {ECO:0000256|PIRSR:PIRSR001222-
FT                                51}.
FT   BINDING     489    489       Substrate. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00700}.
FT   MOD_RES     487    487       N6-carboxylysine. {ECO:0000256|PIRSR:
FT                                PIRSR001222-50}.
SQ   SEQUENCE   838 AA;  90119 MW;  9C7DA5807902A7D0 CRC64;
     MKLVPREIEK LALHNAGFLA QKRLARGLPL NYTEAVALIA TQILEFVRDG DRTVSELMDI
     GKQLLGRRQV LPAVPHLLDT VQVEGTFKDG TKLITVHDPI VSDNGNLELA LHGSFLPVPS
     FDKFVQNVVD SHPGVLVFGS GKIVPNMGRK AVTLKIVNKA DRPIQIGSHY HFIEVNPSLV
     FDRRRAYGMR LNILAGTATR FEPGDTKYVS LVSIGGAKVI RGGNGIADDP VDASRLEKVM
     DDVVARGFGN EHQPDPSEGI VGENSSFTVE VSREAYANMY GPTTGDKIRL GDTELYAEIE
     RDFAVYGDEC VFGGGKVLRD GMGQATGFPT SSCLDTVITN AVIIDYTGIY KADIGIKGGL
     IVAIGKAGNP DDMDGVLPNM IVGVNTEVIA AEGMIVTAGG IDCHIHFICP QLAQEAISSG
     ITTLVGGGTG PADGTRATTC TPAPFHMQLM LQSTDDLPIN IGFTGKGNSA KPDGLIEIIK
     SGAMGLKLHE DWGSTPAAID NCLTVAEAFD IQVNIHTDTL NESGCVEHTI AAFKDRTIHT
     YHSEGAGGGH APDIIKVCGV KNVLPSSTNP TRPFTSNTVD EHLDMLLVCH HLDKDIREDV
     AFAESRIRAE TIAAEDILHD MGAISIIASD SQAMGRVGEV ITRTWQTAHK MKMQRGRSIE
     FSGSDNDNFR IKRYIAKYTI NPAIANGFSN YVGSIEVEKF ADLVIWKPSF FGAKPEMVIK
     GGVIAWANMG DPNASIPTPE PVMMRPMFGA FGKAASSNSI AFMSKVAKDL GIANEYGLKK
     RVEAVGNVRG LTKLDMKLND ALPKIDVDPE TYTVTANGEA LKCEPASSVP LSRNYFLF
//
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