ID A0A2H5AUY7_9ACTN Unreviewed; 733 AA.
AC A0A2H5AUY7;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=Multidrug transporter {ECO:0000313|EMBL:AUG75958.1};
GN ORFNames=CFP65_1041 {ECO:0000313|EMBL:AUG75958.1};
OS Kitasatospora sp. MMS16-BH015.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Kitasatospora.
OX NCBI_TaxID=2018025 {ECO:0000313|EMBL:AUG75958.1, ECO:0000313|Proteomes:UP000239175};
RN [1] {ECO:0000313|EMBL:AUG75958.1, ECO:0000313|Proteomes:UP000239175}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MMS16-BH015 {ECO:0000313|EMBL:AUG75958.1,
RC ECO:0000313|Proteomes:UP000239175};
RA Kim S.B., Yun B.-R.;
RT "Genome sequence of Kitasatospora sp. MMS16-BH015.";
RL Submitted (NOV-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC (TC 2.A.6) family. MmpL subfamily. {ECO:0000256|ARBA:ARBA00010157}.
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DR EMBL; CP025394; AUG75958.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2H5AUY7; -.
DR KEGG; kit:CFP65_1041; -.
DR OrthoDB; 2365435at2; -.
DR Proteomes; UP000239175; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR004869; MMPL_dom.
DR InterPro; IPR000731; SSD.
DR PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR PANTHER; PTHR33406:SF6; MEMBRANE PROTEIN SCO0839-RELATED; 1.
DR Pfam; PF03176; MMPL; 2.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000239175};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 195..216
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 223..245
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 257..276
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 297..322
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 334..355
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 388..408
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 548..565
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 572..596
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 602..625
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 646..667
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 679..705
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 241..355
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
SQ SEQUENCE 733 AA; 76022 MW; 47D88D3033163061 CRC64;
MIRALTGYST RNPWKVILIW VLLGITLTGV SGTLMYRVTQ TQTGDFLPRG YDSAAALRIA
EERFGVKPDA NAVTVLVART DGAKLGEADQ RKIAASAEKL AHQRVVTPKL KDDAPAFLGE
DYSQTPSVQS LMLAPDGRFQ LLSAGLVGNS LDPALQRTFK AFRDSARAEF AAQGLRTGFT
GGLADSVDAA DADEVAGKIT GALVMALIVL LNVLVFRGVL AAILPLIAVT LIGGAASGAV
IGIAMLTGVK LDPGTPMLIQ VVLIGIGVDY LIFLLFRFRE RLRARPEADR KELAGETAGR
VGTAITSAAL TIVAAFATLG VASFGQFRVL GPAIAVSVLV MLLGSLTLMP ALLAVCGRKM
FWPSRALMLE PRPGVAARLA DLVTRRPVLA ALGSLALLAA LAAGVIGIRM DYGFGSDGPK
TAATATAAEI SRALPAGVSD PTTVYVTAKD SARPLDGPAG LDGLERALGA VPGVGKVGAT
TLSPDHRAAR IDLYLTADQQ SQQARDLVAG PLRAAVAAHT PAGLTAHLGG TAAIFTDVAT
VVDHDLRIVF PVAAALIALI LFMLLRSLLA PAVLLISVGL CFAATLGAST LVFQHAAGNP
GVAFTLPLVL FLFVVALGTD YNILITDRIR EEMARPGSAR SAVARALRHT APAIATAALV
LAGSFAALGA TPASRQVGFA TALGILLSAF LLSMVLVPAV ATLLGRSIWW PLRPRSTPEP
AAPPREPAHA ARY
//
