ID A0A2H5AZ62_9ACTN Unreviewed; 1524 AA.
AC A0A2H5AZ62;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Non-ribosomal peptide synthetase {ECO:0000313|EMBL:AUG77446.1};
GN ORFNames=CFP65_2621 {ECO:0000313|EMBL:AUG77446.1};
OS Kitasatospora sp. MMS16-BH015.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Kitasatospora.
OX NCBI_TaxID=2018025 {ECO:0000313|EMBL:AUG77446.1, ECO:0000313|Proteomes:UP000239175};
RN [1] {ECO:0000313|EMBL:AUG77446.1, ECO:0000313|Proteomes:UP000239175}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MMS16-BH015 {ECO:0000313|EMBL:AUG77446.1,
RC ECO:0000313|Proteomes:UP000239175};
RA Kim S.B., Yun B.-R.;
RT "Genome sequence of Kitasatospora sp. MMS16-BH015.";
RL Submitted (NOV-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
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DR EMBL; CP025394; AUG77446.1; -; Genomic_DNA.
DR KEGG; kit:CFP65_2621; -.
DR OrthoDB; 2472181at2; -.
DR Proteomes; UP000239175; Chromosome.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0043604; P:amide biosynthetic process; IEA:UniProt.
DR GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProt.
DR GO; GO:0019752; P:carboxylic acid metabolic process; IEA:UniProt.
DR GO; GO:0008610; P:lipid biosynthetic process; IEA:UniProt.
DR GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR GO; GO:0044550; P:secondary metabolite biosynthetic process; IEA:UniProt.
DR CDD; cd05930; A_NRPS; 1.
DR CDD; cd19540; LCL_NRPS-like; 1.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.980; -; 2.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 3.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 1.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR020802; PKS_thioesterase.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR001031; Thioesterase.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 1.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR Pfam; PF00668; Condensation; 1.
DR Pfam; PF00550; PP-binding; 1.
DR Pfam; PF00975; Thioesterase; 1.
DR SMART; SM00823; PKS_PP; 1.
DR SMART; SM00824; PKS_TE; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 2.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 2.
DR PROSITE; PS50075; CARRIER; 1.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000239175}.
FT DOMAIN 982..1057
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 966..985
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1055..1076
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1308..1414
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1357..1384
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1524 AA; 158942 MW; CF7AEE1A6865A1FE CRC64;
MYPLSFAQQG MWFLNQLEGP DATYNVPVTA RLRGPLDTAA LQAALLDVVT RHEALRTVFG
EADGTPHQRV LSPAEAGPAL ELLEVAPAEL DRVLDETARR PFDLARDLPV RARLLRTSPQ
EHVLALVLHH VACDGWSMPP LLRDLSTAYA ARTAGQEPGW APLPVRYSDY TLWQRELLGS
REDPASLISG QLAFWQGALA GLPEELPLPC DRAVPPAAAT SAGATLTLAA DAGLHARLLT
LAQDNGCTLF MVLQAALATL LTRHGAGEDV PLGIPTAGRT DEALDELVGF FVNTVVLRAD
TGGNPTFRQL LLRLRDAATD AYAHQDVPFD QVVEALNPPR GAARHPLFQV MTALAEQRPA
DGLKLTGLTT TMLRRPVDTA KFSLSVDFED RRDQGGRPAG LGIGWEYATD LFEERTVEAL
GDRLLRLLAG AADDPDRPVH ELPLLSAAER RQQLVTWNGP ARAESFVDLP QLVRRWAAER
PEAVAVSDGA VRYTYRELAE RVEQLAGALA AAGTGPDDLT AILSDRNAWF VTAALGALAA
GSGYLALDAT VPEARVRQML ADSGAGLLLT APDLAEPTRA VAGRLPAGVR HVRPGRDTAP
GRPAGGVGPE HLAYAVFTSG STGRPKCVLV PHRGLSNHLL AVAELYGLTE RDTMAFNAPL
TFDVAVWQAL TTTLVGGRVH VIDEDTTRDP RSLVHCVATE RITVLQIVPQ VLRAILDMWD
LDPSTVPGLA GLRWMLVHGE DLPPDLVDRW FARHPDIPLA NVYGPAECSD DVSISVITAQ
DDFRRRRAPI GQLLRNMQAY VLDDHLQLLP AGIPGELYVG GAGLARGYAG RPEVTAQRFV
ANPFGEPGDR MYRTGDLVRW NTVGELEFLA RVDHQVKIRG FRVEPGEVQA VLEQHDLVHQ
AFVAAREDLP GDKRLVAYVV PTAAGEPVDG EELRRHAALL LPPHMVPAAV VHLDALPVTA
NGKIDRKALP APSAGPATAG RPPRTAEERA LCGLFAEVLG RPEVGVDEDF FALGGHSLLA
MRLVSLIRSS QGLELGVRTL YAAPTVAGLL ATAGRGSAGP ATAGSPASAP ASTAASASGA
SDPAAPAFAS ASGASDPAAA TAGPAAAAAF ASASGGSDPA AAAAGTASDA AALALASAPA
GTASDAAASA AAALAEDFAV LLPLRPGTGG RPLFCVHPAT GLAWSYTGLA GLLPPEVPVH
GLQAPGLADP AELPADLETM LDHLLARIRA AQPTGPYRLL GWSLGGNIAH ALAARLEAEA
EQVELLALVD SFPGPAWPYP DGVAPELWDE WSLLATLLPA AADPTGGAMR TVAADPTGRA
VPTGATDPTG GAMPTGAADP TGGAVPTGAT DRTDTADPAG TAGSTDTADP AGTAGSTDTA
DPAGTAGSTG AADPTDRAVP ADTAGPADTA DPTGAADLRV RLTELRATAA EHTGLAPEVL
DRLVAVGVNA SRLIAEYRPV PVRAPALHFT ATLGHGPGRP GPETWLPHLA ELDRHELACR
HEEAMGPEPR ALVAAVVGAL LARS
//