ID   A0A2H5B2X0_9ACTN        Unreviewed;      1010 AA.
AC   A0A2H5B2X0;
DT   28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   SubName: Full=Transcriptional activator {ECO:0000313|EMBL:AUG78727.1};
GN   ORFNames=CFP65_3957 {ECO:0000313|EMBL:AUG78727.1};
OS   Kitasatospora sp. MMS16-BH015.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Kitasatospora.
OX   NCBI_TaxID=2018025 {ECO:0000313|EMBL:AUG78727.1, ECO:0000313|Proteomes:UP000239175};
RN   [1] {ECO:0000313|EMBL:AUG78727.1, ECO:0000313|Proteomes:UP000239175}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MMS16-BH015 {ECO:0000313|EMBL:AUG78727.1,
RC   ECO:0000313|Proteomes:UP000239175};
RA   Kim S.B., Yun B.-R.;
RT   "Genome sequence of Kitasatospora sp. MMS16-BH015.";
RL   Submitted (NOV-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the AfsR/DnrI/RedD regulatory family.
CC       {ECO:0000256|ARBA:ARBA00005820}.
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DR   EMBL; CP025394; AUG78727.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2H5B2X0; -.
DR   KEGG; kit:CFP65_3957; -.
DR   Proteomes; UP000239175; Chromosome.
DR   GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR   CDD; cd15831; BTAD; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 3.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 2.
DR   InterPro; IPR005158; BTAD.
DR   InterPro; IPR002182; NB-ARC.
DR   InterPro; IPR001867; OmpR/PhoB-type_DNA-bd.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR35807:SF1; TRANSCRIPTIONAL REGULATOR REDD; 1.
DR   PANTHER; PTHR35807; TRANSCRIPTIONAL REGULATOR REDD-RELATED; 1.
DR   Pfam; PF03704; BTAD; 1.
DR   Pfam; PF00931; NB-ARC; 1.
DR   Pfam; PF13424; TPR_12; 1.
DR   PRINTS; PR00364; DISEASERSIST.
DR   SMART; SM01043; BTAD; 1.
DR   SMART; SM00028; TPR; 5.
DR   SMART; SM00862; Trans_reg_C; 1.
DR   SUPFAM; SSF46894; C-terminal effector domain of the bipartite response regulators; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF48452; TPR-like; 4.
DR   PROSITE; PS51755; OMPR_PHOB; 1.
PE   3: Inferred from homology;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW   ProRule:PRU01091}; Reference proteome {ECO:0000313|Proteomes:UP000239175};
KW   Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT   DOMAIN          6..106
FT                   /note="OmpR/PhoB-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51755"
FT   DNA_BIND        6..106
FT                   /note="OmpR/PhoB-type"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01091"
SQ   SEQUENCE   1010 AA;  109535 MW;  40FC2F21958D34CA CRC64;
     MSAATSRGAQ EGQEAAEFAV LGSLEIRSGG ESVLVSGALQ RRVLVMLLLE AGRVVPVSRL
     VAAGWNEDPP DSAEHQVRKT VAKLRGRIPR GPELILTDGP GYRAVVGPDQ LDLLRHQQLL
     TQAREALEAG DPGQAVARFR AALALWRGPV LSGAGGPVID AASTALEEQR LGAAEQLYDL
     CIEAGEAAAV TGELRRLVED HPLRESLRSR LMLALYHSGQ QAAALDEFAR ARRHLAEELG
     IDPGAELTEL QERILRQNLS PAQRPAAVVT APAAAEAPYA LPFDVRDFSG RGTELQWVAE
     AAERAVPGIS TVLALDGMGG SGKTALAVRA AHLLAARYPD GCLFIDLHGF TPGQHPLSAF
     HAQGDLLAAA GIPSEEIPTV PAGRAARWQS FVRGRRLLLV LDNAASSEQV RGLLPAASDS
     LVLVTSRPRL TGLDGVRWRS VGALPEPDSK EILRNTLGPE RVAREPEAAR ELLRLCGGLP
     LAVRIAAARL ANRPHWTVQH LVERLRDHSR RLDELTSEGR GVAGALLLSY QSMPAEQRTA
     FRLLGHHPGR YLDAAEAAAL LDTDVLTAED VLEELVDVRL LEAREPGVYA LHDLVRSFVQ
     RVAQAEKATE DGQAVRRLLD HYVLMAERAG DVLFPGRRRY REDGEEQPAE PAGPAFDHKD
     KALLWLDQHR DGMLAAVDAA YTEGLYWHAA RLPRELGFHS SIRAYDASAN AALEKAVAAS
     RRLGDRSLTR LNLTNLGMGM WRLGRLSDAV ARLEEAAELS RQMADDLSEA ACQARLGQAY
     NSMGELERAL ELNQEVNRRA RELGLTRLDG SSLSMLGLIK VRMGRFEEAA EAAERAVAIF
     DSIQEVPLSV DALSNLSLAV EGLGRHEEAL ERAEEALERC ERINLPSVLP LVLARRADAL
     VRLGRLAEAA DSADHALARA AGSIDDIHRA AVHLTVGRVR YAQGELAPAR AQQLLAHEIA
     CRMELRYDEA CALRGLARTT GAQGDFVLAR RHQASAERLF TLMKVPETAW
//