ID A0A2H5B3M6_9ACTN Unreviewed; 1131 AA.
AC A0A2H5B3M6;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Adenylate/guanylate cyclase {ECO:0000313|EMBL:AUG78987.1};
GN ORFNames=CFP65_4233 {ECO:0000313|EMBL:AUG78987.1};
OS Kitasatospora sp. MMS16-BH015.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Kitasatospora.
OX NCBI_TaxID=2018025 {ECO:0000313|EMBL:AUG78987.1, ECO:0000313|Proteomes:UP000239175};
RN [1] {ECO:0000313|EMBL:AUG78987.1, ECO:0000313|Proteomes:UP000239175}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MMS16-BH015 {ECO:0000313|EMBL:AUG78987.1,
RC ECO:0000313|Proteomes:UP000239175};
RA Kim S.B., Yun B.-R.;
RT "Genome sequence of Kitasatospora sp. MMS16-BH015.";
RL Submitted (NOV-2017) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CP025394; AUG78987.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2H5B3M6; -.
DR KEGG; kit:CFP65_4233; -.
DR OrthoDB; 5476461at2; -.
DR Proteomes; UP000239175; Chromosome.
DR GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProt.
DR GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd07302; CHD; 1.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR041664; AAA_16.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR16305:SF28; ADENYLATE CYCLASE 10; 1.
DR PANTHER; PTHR16305; TESTICULAR SOLUBLE ADENYLYL CYCLASE; 1.
DR Pfam; PF13191; AAA_16; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR SMART; SM00044; CYCc; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE 4: Predicted;
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000239175}.
FT DOMAIN 40..170
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
FT REGION 539..558
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 942..961
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1083..1131
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1131 AA; 116852 MW; 29E29E6B889DB4B1 CRC64;
MNCTSCAQEL PAGARFCPGC GTPAAAAPAR PVVDERRLVT LVFCDLVGST ALSGRLDPEA
LRSVTLRYFE LMTARIEAHG GTVEKFIGDA VMAVFGIPVL HEDDARRALA ATLDMRTALA
GLNAELEAAL GIRLNVRIGV NTGEAVASTD ASSRQALVSG EVVNIAARLE QNAGPGEILI
GPDTLRAVGP AARTEDAGLL TLKGKAEPFP AYRLLGLHED APELLRRFDT PFIGRSLELA
VLENALAIGR RGSGLLTVAG EAGIGKTRLL REWLRRTTPR YGAGRCRPYG ESGSLAPLAE
AVRQLLGPGP AGPEVPPALR AGLLRDGTPS PTVADTCAAL GELFAGFAPG GPTVLILDDF
HWAGPALREA VARLATGPGP VLVVCAARPE LVERVPEWAD TGRLIPLPGL SPTESHRLAA
GLAEVTAHTT GPVEVTAHGA GLAAAAGRTD AGTGGPRPTG SDAAGALLAS LVERAEGNPL
HLEQLYAMAA DGRDPGELPP TVHALLGARI DALAAPERTA LSLAAVVGRE FERGELTGLA
RSGPEGRAGG ELAPDAAGLD SVRPTLHRLT RRRLVEADQD EARYRFSSGL VQEVSYQGMA
KRVRADRHER VAELLTDRGA GDATLGGHLA RAYRYRAQLG TLDPHTERLR HRAAAHLAAA
GAQALARADL GWADELLTGA VELAREEDPG WLTTAWRLAE VRLATGRVEE GRALLLRVAG
AADPVLAAHA RLGLAVLDPG PGLADAARTA EQVLPLFEAA GEELGQARAC LRLAQHQQVL
GRHGTADRLL DRALAHAVRA GAEPERAAAL GAVGVSLWLG PLPVPAAVER CRALLAEHGA
DRRAVRITLN CPLAVLLALR EDWAGARQCL AEAAALGEEL GFAEALVFLP VFRAAVEALA
GRPSRAAELL RAVERTCRDL GAVTLLPAIT RDLTRALLDA GDSVDGDAGD NPGGDAGDNA
SRAAGADAIE AAAAGAGEAD PAAADAADLH GSLARLHALA GRATAADRAA ARAVAEAAGT
DSPVVRATAA LDRAHAALAL GRPAEAASWA EQAHHWYRTK GHLPGLRRAA ALLGTDLSAA
ALSPETRHAE ASAAEVPGPE HPAAGTPTAT APGTTAPGAE RPTRTEESEP R
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