ID A0A2H5N2S4_CITUN Unreviewed; 3414 AA.
AC A0A2H5N2S4;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Cysteine-rich receptor-like protein kinase 10 {ECO:0008006|Google:ProtNLM};
GN ORFNames=CUMW_010290 {ECO:0000313|EMBL:GAY34227.1};
OS Citrus unshiu (Satsuma mandarin) (Citrus nobilis var. unshiu).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Sapindales; Rutaceae; Aurantioideae; Citrus.
OX NCBI_TaxID=55188 {ECO:0000313|EMBL:GAY34227.1};
RN [1] {ECO:0000313|EMBL:GAY34227.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=29259619; DOI=10.3389/fgene.2017.00180;
RA Shimizu T., Tanizawa Y., Mochizuki T., Nagasaki H., Yoshioka T., Toyoda A.,
RA Fujiyama A., Kaminuma E., Nakamura Y.;
RT "Draft sequencing of the heterozygous diploid genome of Satsuma (Citrus
RT unshiu Marc.) using a hybrid assembly approach.";
RL Front. Genet. 8:180-180(2017).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAY34227.1}.
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DR EMBL; BDQV01000002; GAY34227.1; -; Genomic_DNA.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd14066; STKc_IRAK; 4.
DR Gene3D; 3.30.430.20; Gnk2 domain, C-X8-C-X2-C motif; 11.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 5.
DR InterPro; IPR002902; GNK2.
DR InterPro; IPR038408; GNK2_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR27002:SF814; ATP BINDING PROTEIN; 1.
DR PANTHER; PTHR27002; RECEPTOR-LIKE SERINE/THREONINE-PROTEIN KINASE SD1-8; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 3.
DR Pfam; PF00069; Pkinase; 2.
DR Pfam; PF01657; Stress-antifung; 10.
DR SMART; SM00220; S_TKc; 5.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 5.
DR PROSITE; PS51473; GNK2; 11.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 5.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 5.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Kinase {ECO:0000256|ARBA:ARBA00022777}; Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..3414
FT /note="Cysteine-rich receptor-like protein kinase 10"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014123243"
FT TRANSMEM 1679..1704
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2065..2084
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2967..2988
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 30..132
FT /note="Gnk2-homologous"
FT /evidence="ECO:0000259|PROSITE:PS51473"
FT DOMAIN 138..244
FT /note="Gnk2-homologous"
FT /evidence="ECO:0000259|PROSITE:PS51473"
FT DOMAIN 358..634
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 689..793
FT /note="Gnk2-homologous"
FT /evidence="ECO:0000259|PROSITE:PS51473"
FT DOMAIN 853..958
FT /note="Gnk2-homologous"
FT /evidence="ECO:0000259|PROSITE:PS51473"
FT DOMAIN 960..1067
FT /note="Gnk2-homologous"
FT /evidence="ECO:0000259|PROSITE:PS51473"
FT DOMAIN 1136..1407
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 1439..1542
FT /note="Gnk2-homologous"
FT /evidence="ECO:0000259|PROSITE:PS51473"
FT DOMAIN 1548..1655
FT /note="Gnk2-homologous"
FT /evidence="ECO:0000259|PROSITE:PS51473"
FT DOMAIN 1764..2042
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 2087..2188
FT /note="Gnk2-homologous"
FT /evidence="ECO:0000259|PROSITE:PS51473"
FT DOMAIN 2196..2301
FT /note="Gnk2-homologous"
FT /evidence="ECO:0000259|PROSITE:PS51473"
FT DOMAIN 2364..2640
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 2716..2823
FT /note="Gnk2-homologous"
FT /evidence="ECO:0000259|PROSITE:PS51473"
FT DOMAIN 2829..2934
FT /note="Gnk2-homologous"
FT /evidence="ECO:0000259|PROSITE:PS51473"
FT DOMAIN 2836..3250
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 2661..2680
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 2392
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 3414 AA; 382304 MW; 8C0725F99CDAFBAC CRC64;
MPIVIFSASK TIHLLHLLSF LSLVMSQSPE NMPFHCSQLP NNAASDKFTS NLRRLFETIS
EVAGKDAYNK TTEGKYPDKV YGLYLCRGDV NNESCGECVD LATDTIQKDC DGTKEAVIWS
DKCMVRYSDR SLSPNSETWP SNCSTHRENS TEPETLRKTV AKSLKEVIAM ATLNNESKYA
THVVNFSSKH KLYSLVQCIP ELSTEDCRAC LTSAATSILR CYQDKKGARF LNPSCNIRFE
LYPFFTSNPP PAAGPNVINP LKATVEAFGT ELYMVEHDST SNVPGFHQVE GTQTENGLKL
AVQYQEERAI SREAQLLELG EIQIGSHYSY ILREEKEVES KELPLFPFDL TVEATQHFSD
ENKLGEGGFG PVYKGVLADG KEIAVKRLSR TSGQGLEEFM NEVTVIAKLQ HKNLVRLLGC
CLRGNELLLI YEYMPNKSLD FLLFDSTRNG QLDWERRVGI INGIARGLLY LHEDSRLKII
HRDLKASNIL LDHDMNPKIS DFGMARIFRG NQNEANTNRV VGTYGYMAPE YAMEGLFSVK
SDVFSFGVLL LEIISGKKNS SFYLSDESRS LLAHAWKLWC EGNALELMDP VLKQSFNPDE
VLKCIHIGLL CVQADPEDRL TMSSVVVMLA SDTVTLPKPT QPPFSFSRVA LKMTMLFWAS
IITLRLFLLL AILSHSHVIM SQTTFVDKNM VLTCPASINN INTSSYTFIR NVHSLFNRKL
HSEAGNSLYY SATEGHFPDT AYGLYLCKFD ITFQSCQRCI ATAVKAVMKK CNGTRKAIIW
YRECMVRYSD KSLPIMDTST VLCMYIVRNV SVPRNVKSYR RTMPTAANLA SQAIRWLHFL
SIVSSVMSQY VVEEDMVLSC SVSNNTASNT FTSNLNILFN QKLHTEAGKS LYYNASEGEF
PDSVYGLYLC KFNVSFQSCQ NCIVAAVNSV LQKCSGTKEA LIWYQVQECM VRFSDHSLSL
MDTSAPLCMK IFQNTYNVTK SLAQSFNDVI AMPSLSSFRN ATKGTNISNI IRLETFGQCI
PVLSVDDCRD CLNNTIRWIQ RCFDPPGTGF GRILFPSCIM GFELHSYSKV PAVGALAPSS
APEEKRNSQE VQFLHWEGRI GNHYSYDILR GGKQQAESQE FPLFPLRLAL EATNHFSDEN
KLGQGGFGPV YKGTLADGKA IAVKRLSRTS GQGLQEFKNE VNLIAKLQHK NLVRLLGCCL
EGQELLLIYE YMPNKSLDVH LFDATRSVQL DWKRRLSIIN GIARGILYLH EDSRLKIIHR
DLKASNILLD DDMNPKISDF GLARIFGGNQ NQANTNIIAG TYGYMAPDFG VLLLEIISGR
KNNGFYFSEH GQTLLTYTWK LWCEGPAVEL IDPVIKQSCA PDELLKFIHI GLLCVQQDPA
DRPTMSSVVV MLASDSMTIP QPTEPAFSVG RVVANSGHFL SPDKMYPPAT LHDLAFGDSP
PYNTCSSSAA DYGHAGPIYS NLKKVLISLA LNASAAKFSD ASSGNDSDRV YGLYMCLNYI
SNDTCNNCIT TATQDITKLC PNKTDAIVWE EVCQLRYAYG NFFGQLDVPG NIPKYNRKNI
SEPERYRSVV NNTLNNLTKL AAFDPSNEMY ATGEVPFTNS DTLYALVQCT KDLSADDCDA
CLNKAIADIL SCCYFSRGAR LLSRSCYLRY ELYAFYNGDT EASVSVGNQA SGKSNQRRMW
MIIILAAVAA FLLLVVASTG YFFAAKKVAR KRKGMVRKQI QLHKIGDASK TGLRYQHVRG
RDDDLKAQDF YIDLETLHVA TSNFSDSNML GQGGFGPVYK GVLSDGKEIA VKRLSSCSEQ
GYAEFTNEVL LILKLQHKNL VKLLGFCVDG DEKLLVYEFM PNSSLDAILF DPRKRGLLCW
SKRINIVNGI AKGILYLHED SRLRIIHRDL KASNVLLDYD MNPKISDFGM ARIFAGSEGE
VNTARIVGTY GYMAPEYAME GLYSTKSDVF SFGVLLIEII TGRRNRGFNQ SRGATAPNLL
AYAWHLWNEG NALDLIDPLL TDTCSPDEFL RYIHIGLLCV QEDAFGRPTM SSVVVMLQGE
TITLCQPQKP AFSFGRVTDD DDNNYCSVNA MLLLVVQFFT LSIFTDANPL DIACSNTSYA
PNSPFESNLK LLLESIATNT SQGFYNLSIG DDPNRVFGRA LCRGDVNRTV CQNCLENARH
EILKNCKTAE EAIIWYELCQ IQYSYRKFLV MVYAGQYAEK WNNQWKSVSN PARFIEVLTY
LMTNLSIEAS SDPAMFAVGE VKFPKRKTIY GLVQCTRDIN SRDCNDCLTG ALGDLKACCG
AREAGIIVNE NCNLRFQLSL FYNASTRISL TYPTSTDEKR SQRGLLHELA GPISVSLTQE
GDLVSSEELP FVHLAVIKAA TDGFSDSNKL GQGGFGTVYK CVLPNGKEVA VKRLSRKSWQ
GLEEFKNEII LIAKLQHRNL VRLVGCGIEG EEKLLIYEFM PNRSLDCFIF DSERRLQLNW
NTCYNIIGGI AKGLLYLHED SRLKIIHRDL KPNNVLLDKD MVAKISDFGM ARIFCENQKT
ANTRRVVGTY GYMAPEYAME GLFSVKSDVF SFGVIVLEII SGKRNSGFYL TGHAQTLLAY
VWQLWKEGKE MEFVDPLLMK SSSIPQVVRC IHIGLLCVQE DPAVRPTMSN VVALLGSASI
ALSEPRQPPF PVGRTIVLAE QPSTKDPSIE KKKNTRKRKK GQRIVFVIHS TQQKPGIPNA
ALEILHFSFT AAVNPEYVYN FCPTTANFTR NSTYDKNLNL FLSSIPTNAS RGNGFSSGFF
NATAGQDPNR VYGLFLCRGD QTTSGCQDCV TYATRNVLQL CRVSKQTILW YAECLLRYSD
QSFFSTMATV PGVSLLNTQN VTDQGRFNEL VGTQMSQAVT QAVNNTKRFA TRKANFTASQ
TLYSLAQCTP DLSSSDCNIC LRGAIAQLPN CCSGKQGGRV LTPSCNVRYE LYPFYNESAT
APPAPAPVLL LLHLNWLSKS ESQSSTIIAS VFPIAVTAVL FIVGYCFLEG KQKKKVDVGR
FISFNTEICI GLRGILLGGR EKRYLCLTNF VANYKRLDYF LYVLMFAMCT DPEKQGQLDW
SRRYKIIGGI ARGILYLHED SRLRIIHRDL KASNILLDAE MNPKISDFGM ARIFGVDQTQ
GNTSRIVGTY GYMAPEYAMH GQFSVKSDVY SFGVLVLEII TGKKNSNFYQ TDGAADLLSY
AWKQWRDGTP LQLLDPNLTD SYSRNEVIRC IHLGLLCVQE DPTERPSMAT IVLMLNSYSV
TLPSPQQPAF FIGSRTERSL PPKEFEFSDK STSKSMPWSV DEASITECMI IVWMSNDTTL
GYQIFHYDVA CVLCRLEFSL LDKMLYKFLN TNVNYFVEME YLENEHAFEE LQETRANDVN
EIMEPNKCEP ALGMLFDNHE EMFAFYKAYG KQEGFPVKVR STKNGTDGIR QVRK
//
