ID A0A2H5SZP3_RHIID Unreviewed; 1049 AA.
AC A0A2H5SZP3;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 22-FEB-2023, entry version 23.
DE RecName: Full=MMS19 nucleotide excision repair protein {ECO:0000256|RuleBase:RU367072};
GN ORFNames=GLOIN_2v1762658 {ECO:0000313|EMBL:POG82073.1};
OS Rhizophagus irregularis (strain DAOM 181602 / DAOM 197198 / MUCL 43194)
OS (Arbuscular mycorrhizal fungus) (Glomus intraradices).
OC Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Glomeromycotina;
OC Glomeromycetes; Glomerales; Glomeraceae; Rhizophagus.
OX NCBI_TaxID=747089 {ECO:0000313|EMBL:POG82073.1, ECO:0000313|Proteomes:UP000018888};
RN [1] {ECO:0000313|EMBL:POG82073.1, ECO:0000313|Proteomes:UP000018888}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DAOM 181602 / DAOM 197198 / MUCL 43194
RC {ECO:0000313|Proteomes:UP000018888};
RX PubMed=24277808; DOI=10.1073/pnas.1313452110;
RA Tisserant E., Malbreil M., Kuo A., Kohler A., Symeonidi A., Balestrini R.,
RA Charron P., Duensing N., Frei Dit Frey N., Gianinazzi-Pearson V.,
RA Gilbert L.B., Handa Y., Herr J.R., Hijri M., Koul R., Kawaguchi M.,
RA Krajinski F., Lammers P.J., Masclaux F.G., Murat C., Morin E.,
RA Ndikumana S., Pagni M., Petitpierre D., Requena N., Rosikiewicz P.,
RA Riley R., Saito K., San Clemente H., Shapiro H., van Tuinen D., Becard G.,
RA Bonfante P., Paszkowski U., Shachar-Hill Y.Y., Tuskan G.A., Young P.W.,
RA Sanders I.R., Henrissat B., Rensing S.A., Grigoriev I.V., Corradi N.,
RA Roux C., Martin F.;
RT "Genome of an arbuscular mycorrhizal fungus provides insight into the
RT oldest plant symbiosis.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:20117-20122(2013).
RN [2] {ECO:0000313|EMBL:POG82073.1, ECO:0000313|Proteomes:UP000018888}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DAOM 181602 / DAOM 197198 / MUCL 43194
RC {ECO:0000313|Proteomes:UP000018888};
RX PubMed=29355972;
RA Chen E.C.H., Morin E., Beaudet D., Noel J., Yildirir G., Ndikumana S.,
RA Charron P., St-Onge C., Giorgi J., Kruger M., Marton T., Ropars J.,
RA Grigoriev I.V., Hainaut M., Henrissat B., Roux C., Martin F., Corradi N.;
RT "High intraspecific genome diversity in the model arbuscular mycorrhizal
RT symbiont Rhizophagus irregularis.";
RL New Phytol. 0:0-0(2018).
CC -!- FUNCTION: Key component of the cytosolic iron-sulfur protein assembly
CC (CIA) complex, a multiprotein complex that mediates the incorporation
CC of iron-sulfur cluster into apoproteins specifically involved in DNA
CC metabolism and genomic integrity. In the CIA complex, MMS19 acts as an
CC adapter between early-acting CIA components and a subset of cellular
CC target iron-sulfur proteins. {ECO:0000256|RuleBase:RU367072}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU367072}.
CC -!- SIMILARITY: Belongs to the MET18/MMS19 family.
CC {ECO:0000256|ARBA:ARBA00009340, ECO:0000256|RuleBase:RU367072}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:POG82073.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AUPC02000007; POG82073.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2H5SZP3; -.
DR STRING; 747089.A0A2H5SZP3; -.
DR VEuPathDB; FungiDB:GLOIN_2v1762658; -.
DR OrthoDB; 38995at2759; -.
DR Proteomes; UP000018888; Unassembled WGS sequence.
DR GO; GO:0097361; C:CIA complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR GO; GO:0016226; P:iron-sulfur cluster assembly; IEA:UniProtKB-UniRule.
DR GO; GO:0097428; P:protein maturation by iron-sulfur cluster transfer; IEA:UniProtKB-UniRule.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR039920; MET18/MMS19.
DR InterPro; IPR024687; MMS19_C.
DR InterPro; IPR029240; MMS19_N.
DR PANTHER; PTHR12891; DNA REPAIR/TRANSCRIPTION PROTEIN MET18/MMS19; 1.
DR PANTHER; PTHR12891:SF0; MMS19 NUCLEOTIDE EXCISION REPAIR PROTEIN HOMOLOG; 1.
DR Pfam; PF12460; MMS19_C; 1.
DR Pfam; PF14500; MMS19_N; 1.
DR SUPFAM; SSF48371; ARM repeat; 2.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|RuleBase:RU367072};
KW DNA repair {ECO:0000256|RuleBase:RU367072};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU367072};
KW Reference proteome {ECO:0000313|Proteomes:UP000018888};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 41..301
FT /note="MMS19 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF14500"
FT DOMAIN 556..999
FT /note="MMS19 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF12460"
SQ SEQUENCE 1049 AA; 118316 MW; 9482D66B4E06DC6E CRC64;
MERLVRNYMV TSNDATEEAK SIVSEIVSSI KSGQATLITL VQVLGEFLTN EDVTIRAKGT
GLLSAVLADC PQEQVNNAAI NVLVDFYCER LSDTASVPEL LQGIESLTRF NAFHDENSVK
VAKSIFTSVN VQSFQQTTRH YVFQIFDRLL KHHLSALKQA EQDFVIGFIQ VMDGEKDPRN
LLLAFSLVKL IIHEFDISKR IELLFEVTFC YFPITFKPPP DDPYGITADD LKIALRECLS
ATPYFAELAM PLLIEKLTSS SGNAKKDSME TLASCAPVYG AKSIVPHLEE LWEYLREEVV
NATDDSFEII ALEAIKSVVA TLSSGIINKM DHLQQFLKTI ITECMENLKE PELKLAKPCG
RILMYCAMAS DPSFNIVMLA TLRVLIQQYK ESELATRKKG ILEVLRVFIT ASKNLYGSIE
NPLQDLDADF VTPLSSFKDV YIEIFSSALL SQNEYNELRL CGLLGLHDMI FLHQFFNDDE
VGIILQYFNR AVLEETDQEI SNEALKSLAN IAKYKSNIVL EVTLPVFLDI LPYDKDEMKI
DNIHGMNLKK ANYVKTLDAL SELAIEPILF EAYVPQILNK LDFASAEIDL EYSESLLQSL
HNLLLKKTHH SDISRYVDII IPHLLTKSIG PSLYGNSDIE NTIQSVFFDK KVIKIVAGII
SVITKNLNVS EQSIFISQMF EIFVKGNLNL NYLGFSDQEK ALFSTTFYPL SVESSSQQQN
LTLLFTAAVG SCRKEVPYPS PNISEFLSNL VEISLNTKNE LQHHSLAQLA ASILNKWNQE
NELNQFVETK ILGELRNHFA LSSTGNEVMR QPSLDIFIWL TKALILRTHL LGYRCVDQIT
SQFNDPMLGK RASERFEVLI GESDLLNKQS FAVVKTLHKQ RFFNYCMPIL AEGFKLSSDE
VKHNYLIALS HLLRNIPKQV LLSELPSLIT LLIHSLSLPD AELKSSTIDT FYIISANAPH
IISEHISSLI PLLLSSTKGD KGNTMRVRIS ALQCLGILPN HIPFDVLFPF KSKILRELSA
ALDDKKRLVR KQAVDCRNKW FLFIGPRTD
//
