ID   A0A2H9TJR8_9FUNG        Unreviewed;       248 AA.
AC   A0A2H9TJR8;
DT   28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 1.
DT   27-MAR-2024, entry version 16.
DE   RecName: Full=Steroid 5-alpha reductase C-terminal domain-containing protein {ECO:0000259|PROSITE:PS50244};
GN   ORFNames=PSACC_02286 {ECO:0000313|EMBL:PJF17993.1};
OS   Paramicrosporidium saccamoebae.
OC   Eukaryota; Fungi; Fungi incertae sedis; Cryptomycota;
OC   Cryptomycota incertae sedis; Paramicrosporidium.
OX   NCBI_TaxID=1246581 {ECO:0000313|EMBL:PJF17993.1, ECO:0000313|Proteomes:UP000240830};
RN   [1] {ECO:0000313|EMBL:PJF17993.1, ECO:0000313|Proteomes:UP000240830}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KSL3 {ECO:0000313|EMBL:PJF17993.1,
RC   ECO:0000313|Proteomes:UP000240830};
RA   Quandt C.A., Beaudet D., Corsaro D., Michel R., Corradi N., James T.;
RT   "The genome of Paramicrosporidium saccamoebae is the missing link in
RT   understanding Cryptomycota and Microsporidia evolution.";
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PJF17993.1}.
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DR   EMBL; MTSL01000150; PJF17993.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2H9TJR8; -.
DR   Proteomes; UP000240830; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016627; F:oxidoreductase activity, acting on the CH-CH group of donors; IEA:InterPro.
DR   GO; GO:0006629; P:lipid metabolic process; IEA:InterPro.
DR   Gene3D; 1.20.120.1630; -; 1.
DR   InterPro; IPR001104; 3-oxo-5_a-steroid_4-DH_C.
DR   InterPro; IPR010721; UstE-like.
DR   PANTHER; PTHR32251; 3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE; 1.
DR   PANTHER; PTHR32251:SF17; STEROID 5-ALPHA REDUCTASE C-TERMINAL DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF06966; DUF1295; 1.
DR   PROSITE; PS50244; S5A_REDUCTASE; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000240830};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        38..58
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        125..143
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        149..170
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          106..171
FT                   /note="Steroid 5-alpha reductase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS50244"
SQ   SEQUENCE   248 AA;  28925 MW;  FCF82FE81E1AA670 CRC64;
     MLVSLWALRL GSFLLLRVLI RRKDTRFDRM RDSLPKLALF WGLQAVWVWV TSVPLMWVNM
     CRLETPVGLL DHVGWACWVV GFLCEGISDF QKHCFTQRTS DPRARPFLDT GLWHYSRHPN
     YFGEILLWFG VWLSAASGLA TVYPTRALIS FVSPLLAFTL LVFVSGIPLA EARDDRRNHR
     LMAYKQYKFC TSPLLPLPKT WYASVPIWAK RWLFFDRYQL AFITPHLSRS LESSTLRERP
     RRSASRAS
//