ID A0A2H9TLJ1_9FUNG Unreviewed; 881 AA.
AC A0A2H9TLJ1;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE RecName: Full=Peptidase S54 rhomboid domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=PSACC_01565 {ECO:0000313|EMBL:PJF18623.1};
OS Paramicrosporidium saccamoebae.
OC Eukaryota; Fungi; Fungi incertae sedis; Cryptomycota;
OC Cryptomycota incertae sedis; Paramicrosporidium.
OX NCBI_TaxID=1246581 {ECO:0000313|EMBL:PJF18623.1, ECO:0000313|Proteomes:UP000240830};
RN [1] {ECO:0000313|EMBL:PJF18623.1, ECO:0000313|Proteomes:UP000240830}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KSL3 {ECO:0000313|EMBL:PJF18623.1,
RC ECO:0000313|Proteomes:UP000240830};
RA Quandt C.A., Beaudet D., Corsaro D., Michel R., Corradi N., James T.;
RT "The genome of Paramicrosporidium saccamoebae is the missing link in
RT understanding Cryptomycota and Microsporidia evolution.";
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Chromosome, centromere, kinetochore
CC {ECO:0000256|ARBA:ARBA00004629}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the NDC80/HEC1 family.
CC {ECO:0000256|ARBA:ARBA00007050}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PJF18623.1}.
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DR EMBL; MTSL01000112; PJF18623.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2H9TLJ1; -.
DR STRING; 1246581.A0A2H9TLJ1; -.
DR Proteomes; UP000240830; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0031262; C:Ndc80 complex; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0051315; P:attachment of mitotic spindle microtubules to kinetochore; IEA:InterPro.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR Gene3D; 6.10.250.1950; -; 1.
DR Gene3D; 1.10.418.30; Ncd80 complex, Ncd80 subunit; 1.
DR Gene3D; 1.20.1540.10; Rhomboid-like; 1.
DR InterPro; IPR040967; DUF5595.
DR InterPro; IPR005550; Kinetochore_Ndc80.
DR InterPro; IPR038273; Ndc80_sf.
DR InterPro; IPR022764; Peptidase_S54_rhomboid_dom.
DR InterPro; IPR035952; Rhomboid-like_sf.
DR PANTHER; PTHR10643; KINETOCHORE PROTEIN NDC80; 1.
DR PANTHER; PTHR10643:SF2; KINETOCHORE PROTEIN NDC80 HOMOLOG; 1.
DR Pfam; PF18077; DUF5595; 1.
DR Pfam; PF03801; Ndc80_HEC; 1.
DR Pfam; PF01694; Rhomboid; 1.
DR SUPFAM; SSF144091; Rhomboid-like; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Cell division {ECO:0000256|ARBA:ARBA00022618};
KW Centromere {ECO:0000256|ARBA:ARBA00023328};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Kinetochore {ECO:0000256|ARBA:ARBA00022838};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Mitosis {ECO:0000256|ARBA:ARBA00022776};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000240830};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 58..81
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 101..120
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 182..204
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 92..232
FT /note="Peptidase S54 rhomboid"
FT /evidence="ECO:0000259|Pfam:PF01694"
FT DOMAIN 490..547
FT /note="DUF5595"
FT /evidence="ECO:0000259|Pfam:PF18077"
FT REGION 275..296
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 528..555
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 594..659
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 741..846
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 881 AA; 99445 MW; F00023468893EEF2 CRC64;
MVVGGSTVAY SAAMIVDIER DKTRRRRWIS PPKNSIGYDN NASLASWWNG RRESEKTIIS
LIGINGLVFL AWKFPGLQTF MSRYFMHSTR SHPITMLNSS FSHVSGMHFL VNMIALYSFG
RMLHEKMGRE QFLAFYLSAG LASSAGSHMV RSIRGDFAKS LGASGAVFAV AAGCAHQPDV
RVSLIFLPFV SIPIGYALPA MMAYDAIGLV KRWATFDHAA HLSGALFGYI FYTASTRHIW
PQRYNILKSA GNCFVLAMVE RRLSTAPFQA PTMPSAAPRM SLAGPRQSLG PSRVRGSNVG
TAVSELAGMS IGTEQRKLSL GRSSLDPRES LNRRSSAFGK NLAGTYAGGK DPRPIREKSY
QLEVIKNLIN FLAKSGYPHP ISQKILTAPS AKDFQNIFKF LYAQLDPGYD FGKKFEDEVP
LVMKGLRYPF AGEISKSQLY ACGSMHAWPG LLAMLGWMVD LVNCCDILHA QFETEPSDMT
DLPGSTQTTA SEKVFFDYLC KSYKLFLAGS DNFDPLISEL GASFERRNEV VYQEVEQLSR
VVEEEEAEYQ MLITEEPPLA KAQREQSIYK GDIEKFRKFI SHLEVKRTKF DEVIRNTIND
VEICERELEE HEMLRATLQA QVEAQDICPE DIDRMNSDKE QLVKTLESLS QTKEEANKVF
WERELLVQKK LDAVEKLVQE YNYSGEQIAV IPQEAVNSKG LSLELAFNPH ATRADQLVNL
DIRTQVHPSF NSLREECHAM IHQAQDQLLS LQEALDKLNE ACNDKIEELR SNEKKIERTV
QSYLEEKESC AVENKKTDEE AELLEQTIQK LRSDISSHSI MSQQRLQRAT VEYDQLVTNV
ASEKERIGTD MYRLLEELIN FKTHVESSLE DLEQAFGRED L
//
