ID A0A2H9U9N2_9GAMM Unreviewed; 709 AA.
AC A0A2H9U9N2;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000256|ARBA:ARBA00021982};
DE Flags: Fragment;
GN Name=mutS {ECO:0000313|EMBL:PJG60717.1};
GN ORFNames=CUC53_00300 {ECO:0000313|EMBL:PJG60717.1};
OS Aeromonas cavernicola.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Aeromonadales;
OC Aeromonadaceae; Aeromonas.
OX NCBI_TaxID=1006623 {ECO:0000313|EMBL:PJG60717.1, ECO:0000313|Proteomes:UP000235861};
RN [1] {ECO:0000313|EMBL:PJG60717.1, ECO:0000313|Proteomes:UP000235861}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MDC 2508 {ECO:0000313|EMBL:PJG60717.1,
RC ECO:0000313|Proteomes:UP000235861};
RA Colston S.M., Navarro A., Martinez-Murcia A.J., Graf J.;
RT "Draft genome sequence of environmental isolate Aeromonas cavernicola sp.
RT nov. MDC 2508.";
RL Submitted (NOV-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000256|ARBA:ARBA00024647}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|RuleBase:RU003756}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PJG60717.1}.
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DR EMBL; PGGC01000003; PJG60717.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2H9U9N2; -.
DR OrthoDB; 9802448at2; -.
DR Proteomes; UP000235861; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 2.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|RuleBase:RU003756};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|RuleBase:RU003756};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU003756};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU003756}.
FT DOMAIN 690..706
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT NON_TER 709
FT /evidence="ECO:0000313|EMBL:PJG60717.1"
SQ SEQUENCE 709 AA; 79491 MW; CFA7A6114C017054 CRC64;
MTLTENIHNH TPMMQQYLGL KAENPEILLF YRMGDFYELF YDDARKASLL LDISLTKRGQ
SAGIPIPMAG VPYHAIEGYL AKLVQLGESA AICEQVGDPA TSKGPVERKV IRIITPGTVS
DEALLSERQD NLIAAVYHDG RRFGYGTMDI SSGRFFINQF DKEETLLAEL QRTNPAELLY
PESFAFLHHI EGRRGLRRRP EWEFELGTAR KLLCQQFGTQ DLVGFGVEQS ETALCAAGCL
MQYVKDTQRT ALPHIRSVRL EQPDHAVIMD AATRRNLELT QNLAGGHDNT LAAVLDGTAT
PMGSRLLKRW LHQPIRDRVI LKGRQSTIKE LIEQNLYDEL GSLLRQVGDV ERVLARLALR
SARPRDLTRL RQAFAQLPEL QRLLADNEHE AVQQLRDRAS TFPALLDLLE RAVMEVPPVL
IRDGGVIRDG FNQELDELRD LANGATASLA RIEEREKLLT GINTLKVGYN KVHGFYIEVS
RANSHLVPAH YIRRQTLKNN ERYIIDELKK YEDKVLTAQS QALALEKRLY EELLDALLPH
LGDLQDSAAA LAELDVLANL AERAETLDYR CPTLIDEDQI LIEAGRHPVV EQVMTDPFIA
NPIRLERERR MLIITGPNMG GKSTYMRQTA LIVLLAHIGA FVPADSAHIG PIDRIFTRIG
ASDDLASGRS TFMVEMTETA NILNNATARS LVLMDEIGRG TSTYDGLSL
//
