ID A0A2H9VP90_9SPHI Unreviewed; 702 AA.
AC A0A2H9VP90;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=ATP-dependent DNA helicase RecG {ECO:0000256|ARBA:ARBA00017846, ECO:0000256|RuleBase:RU363016};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551, ECO:0000256|RuleBase:RU363016};
GN Name=recG {ECO:0000256|RuleBase:RU363016};
GN ORFNames=CLV57_3291 {ECO:0000313|EMBL:PJJ80146.1};
OS Mucilaginibacter auburnensis.
OC Bacteria; Bacteroidota; Sphingobacteriia; Sphingobacteriales;
OC Sphingobacteriaceae; Mucilaginibacter.
OX NCBI_TaxID=1457233 {ECO:0000313|EMBL:PJJ80146.1, ECO:0000313|Proteomes:UP000242687};
RN [1] {ECO:0000313|EMBL:PJJ80146.1, ECO:0000313|Proteomes:UP000242687}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 28175 {ECO:0000313|EMBL:PJJ80146.1,
RC ECO:0000313|Proteomes:UP000242687};
RA Goeker M.;
RT "Genomic Encyclopedia of Archaeal and Bacterial Type Strains, Phase II
RT (KMG-II): From Individual Species to Whole Genera.";
RL Submitted (NOV-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Critical role in recombination and DNA repair. Helps process
CC Holliday junction intermediates to mature products by catalyzing branch
CC migration. Has a DNA unwinding activity characteristic of a DNA
CC helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-
CC DNA). {ECO:0000256|RuleBase:RU363016}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|RuleBase:RU363016};
CC -!- SIMILARITY: Belongs to the helicase family. RecG subfamily.
CC {ECO:0000256|ARBA:ARBA00007504, ECO:0000256|RuleBase:RU363016}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PJJ80146.1}.
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DR EMBL; PGFJ01000002; PJJ80146.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2H9VP90; -.
DR OrthoDB; 9804325at2; -.
DR Proteomes; UP000242687; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-UniRule.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR CDD; cd17992; DEXHc_RecG; 1.
DR CDD; cd04488; RecG_wedge_OBF; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR004609; ATP-dep_DNA_helicase_RecG.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR047112; RecG/Mfd.
DR InterPro; IPR045562; RecG_dom3_C.
DR InterPro; IPR033454; RecG_wedge.
DR NCBIfam; TIGR00643; recG; 1.
DR PANTHER; PTHR47964; ATP-DEPENDENT DNA HELICASE HOMOLOG RECG, CHLOROPLASTIC; 1.
DR PANTHER; PTHR47964:SF1; ATP-DEPENDENT DNA HELICASE HOMOLOG RECG, CHLOROPLASTIC; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF19833; RecG_dom3_C; 1.
DR Pfam; PF17191; RecG_wedge; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU363016};
KW DNA damage {ECO:0000256|RuleBase:RU363016};
KW DNA recombination {ECO:0000256|RuleBase:RU363016};
KW DNA repair {ECO:0000256|RuleBase:RU363016};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|RuleBase:RU363016};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU363016};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU363016};
KW Reference proteome {ECO:0000313|Proteomes:UP000242687}.
FT DOMAIN 287..449
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 458..635
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
SQ SEQUENCE 702 AA; 80355 MW; B497566AF2B37F2D CRC64;
MNGHTLQTPI EYLKGVGAAR AEVLKKELGI HFFDDLLRHY PFRHIDRTRF YKIREVNDEL
PYVQVIARLI NKEILGEKHT KRLVANVRDD TGLMELVWFQ GIKWIEKTLV PGKAYVLFGK
PGSFNGRAQM SHPEMDLYTP EAAKRKGNLT LQPVYSSTEK LKQFQLDSKG LQKLVAALLE
QYGNSITENL PLYILNRFKL MSRAEAYRQI HFPDDAIKLA EAQHRLKFEE LFFLQLKLLR
TKLLRVQKFK GNVFDKIGHY FNEFYEYKLP FELTGAQKRV LKEIRQDTQR GVQMNRLLQG
DVGSGKTIVA LMSMLIAIDN GFQTCIMAPT EILASQHYQT IKGVIGDDFL EVALLTGSTP
QRQRRLIHEK LENGELKILI GTHALIEDKV QYQNLGMVVI DEQHRFGVEQ RAKLWRKNTI
PPHVLVMTAT PIPRTLAMTL YGDLDVSVID ELPAGRKPIE TLHFYESQRL RMFGFMKQEI
AKGRQIYVVY PLIKESEKLD LKNLEDGIEI MRREFPLPQY HISIVHGKLK AAEKEAEMQR
FVKGDTQIMV ATTVIEVGVN VPNASVMIIE NAERFGLSQL HQLRGRVGRG AEQSYCLLMS
KDKLSPDGRV RLNTMVKTNN GFEISETDLK LRGPGNIEGT QQSGIMDLKV ADLVTDQELL
TQIRNFVEVV FSKDPQLAAP ENELLRVAFQ SKTNGLSWDK IS
//
