ID A0A2H9ZWA5_9ASPA Unreviewed; 1772 AA.
AC A0A2H9ZWA5;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE RecName: Full=Mediator of RNA polymerase II transcription subunit 13 {ECO:0000256|ARBA:ARBA00019618, ECO:0000256|RuleBase:RU364134};
GN Name=MED13 {ECO:0000313|EMBL:PKA47598.1};
GN ORFNames=AXF42_Ash014794 {ECO:0000313|EMBL:PKA47598.1};
OS Apostasia shenzhenica.
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Asparagales; Orchidaceae;
OC Apostasioideae; Apostasia.
OX NCBI_TaxID=1088818 {ECO:0000313|EMBL:PKA47598.1, ECO:0000313|Proteomes:UP000236161};
RN [1] {ECO:0000313|EMBL:PKA47598.1, ECO:0000313|Proteomes:UP000236161}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Shenzhen {ECO:0000313|Proteomes:UP000236161};
RC TISSUE=Stem {ECO:0000313|EMBL:PKA47598.1};
RX PubMed=28902843; DOI=10.1038/nature23897;
RA Zhang G.Q., Liu K.W., Li Z., Lohaus R., Hsiao Y.Y., Niu S.C., Wang J.Y.,
RA Lin Y.C., Xu Q., Chen L.J., Yoshida K., Fujiwara S., Wang Z.W., Zhang Y.Q.,
RA Mitsuda N., Wang M., Liu G.H., Pecoraro L., Huang H.X., Xiao X.J., Lin M.,
RA Wu X.Y., Wu W.L., Chen Y.Y., Chang S.B., Sakamoto S., Ohme-Takagi M.,
RA Yagi M., Zeng S.J., Shen C.Y., Yeh C.M., Luo Y.B., Tsai W.C.,
RA Van de Peer Y., Liu Z.J.;
RT "The Apostasia genome and the evolution of orchids.";
RL Nature 549:379-383(2017).
CC -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC regulated transcription of nearly all RNA polymerase II-dependent
CC genes. Mediator functions as a bridge to convey information from gene-
CC specific regulatory proteins to the basal RNA polymerase II
CC transcription machinery. Mediator is recruited to promoters by direct
CC interactions with regulatory proteins and serves as a scaffold for the
CC assembly of a functional preinitiation complex with RNA polymerase II
CC and the general transcription factors. {ECO:0000256|RuleBase:RU364134}.
CC -!- SUBUNIT: Component of the Mediator complex.
CC {ECO:0000256|RuleBase:RU364134}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU364134}.
CC -!- SIMILARITY: Belongs to the Mediator complex subunit 13 family.
CC {ECO:0000256|ARBA:ARBA00009354, ECO:0000256|RuleBase:RU364134}.
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DR EMBL; KZ453122; PKA47598.1; -; Genomic_DNA.
DR STRING; 1088818.A0A2H9ZWA5; -.
DR OrthoDB; 9289at2759; -.
DR Proteomes; UP000236161; Unassembled WGS sequence.
DR GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR InterPro; IPR009401; Med13_C.
DR InterPro; IPR041285; MID_MedPIWI.
DR PANTHER; PTHR48249; MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13; 1.
DR PANTHER; PTHR48249:SF3; MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13; 1.
DR Pfam; PF06333; Med13_C; 1.
DR Pfam; PF18296; MID_MedPIWI; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|RuleBase:RU364134};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU364134};
KW Reference proteome {ECO:0000313|Proteomes:UP000236161};
KW Repressor {ECO:0000256|ARBA:ARBA00022491, ECO:0000256|RuleBase:RU364134};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU364134};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU364134}.
FT DOMAIN 964..1198
FT /note="MID"
FT /evidence="ECO:0000259|Pfam:PF18296"
FT DOMAIN 1350..1746
FT /note="Mediator complex subunit Med13 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF06333"
FT REGION 208..229
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 872..896
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 872..893
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1772 AA; 192105 MW; EC95202B9F062BA9 CRC64;
MKHIRCLAGD DIERVLRQQS RKFITKGLPV IVSPNGMRGR LTGCCPVDIV NQLYARLKAS
DEIPAGAPSI MRSAVCLFRG QKCFVEVTLG YPSCSDRSAE AICSDNVNAV CLRSEDPCTV
SSGKCHHTGS FPKLERTFVY PVEFVLVPVF DRAFARSSFK RFFLQILAGT SPFELWPFWN
FSTLSEHRSQ FLEELAIDFG GTGLKRKYNS SSNSTCSSTS STSSTSSASD HAAFTGATDL
EADADSLTSR QSGLSSNDQL DNDGNRMVAK RIRSSVIDTF GQVTTVGSET AQSLTKSEYS
VVDVVDVAGG GSANAQVGSN WDWEEDERGI GVDIQVLLSE FGDFGDFFES DVLTFGEPPG
TAESQALVFP SIEGGDLSGS PYTMGIDSPD QKISTVGLTS FENFNQSSVT SMEDTQSICV
DTAKDSKASA TTSHTLVLFT GKFDYLKKAE AVLTFAPEYA AVEMSSNEFC TSIFRNPYLP
CSKRVESSQI SSNAYIYSAA PPLIDDSEEN PEKSCKVKLG NGGYGTTGLS GKLYTQVQSG
TKEVHKRLFN VDMPTHKGQN PSSLCVKTSS SGISVLPLMN DKTIEAGHFL LSLKTVLATE
IECIMFQAAM CRIRHMLVSF NCQVPLRLNK RSENAMLDVI SCDASSIHDV LPTKHEARKN
DALPVRIAGD VDVGMHDASV AAPVGVWRPV GVPKGTEPSN KCMFEKSPSL QNNSANEESV
HGQRQALQEF LDALGFLVQQ SASFVDVALD TDDTVGPYSW LALQEQQRRG FSCGPSMVHA
GCGGILATCH YVDIAGVDLM DPLSADVQVS TVISMLQSDI KSALKSAFAS LDGPLSLTEW
CRGRHQSGDS GTTGDGYSFQ CNLSEAKDSL SNVTMGGDPI SSPQSTSSSR EGIRIDDSSQ
KRLNQEVCSS DSETQKLNSR LRPTLSVLPL PLLLVGYQDD WLKTSVSCLP LWEKAPLEPY
ALPKPVSYFA VCPDIDLLTS AATDFFQQLG TVYEACKLGS HTPHNTGSIV ESSPGKLSSS
GLVLVNCPQE LKALSGTMPI SSINDYFVAL SKSWNLTSYV NSLKKVLLDL HFTVTSSTNQ
KEGNTGPCMV VYVVCPFPGH AAVLQTVIQC SKAIGSVALS LDKEKQSLLH SHVAKALCFS
AAADEASVSS VVMLSGFRIP KLVLQIVTVD SLLRLNRPAK ELAILKELAF TVYNKVRRIP
RAVSSAADIP LNVPSRGQST LMHVNSPIPG IWKDCLAPRI SSSVLARETE LDSALRPATW
DNSWQTRVGG LNFDSSRSVE LLFQDDPRYL FEPLFILAEP GFVEHEPSGS KSAAEDNSCI
YMQTSTSGGA TEIGKGSLVD GSEHDCRPAN LHCCYGWTED WCWLICIWTD SRGELLDCGI
FPFGGISSRQ DTKVLQNLFI QVLHHSCQIL SSLSDLGNIK QRDMIITRIG CFFELECQEW
QKAIYSVGGN DVKKWPIQLR RAIPDAVLAN NGTSLEQQEM GLIQERTLPS SPSPSLYSTQ
SKSSFIKGSL GQANAKKPML GGQTGLDSSK GLLHLIRSIS LVSVSMDHSL HLIIPAHFSS
AGGQNNVSTS FPSYLEGFIP VKSLGSLSTS YLLIPSPSMR FLPPSPFQLP TCLTSESPPL
THLLHSKGSA IPQSTGFVIS KSVPTMRRDP VDPLKEDWPS ILAVSLVDHY GGGRSSLVQE
KLTGRGSTGS TAAANKQGRS IGPEAYEMEA HLVLESVAAE LHALSWMTVS PLYVDRRSAL
PFHCDMLLRL RRLLHYADKE FSRPPSDQPD LL
//
