ID A0A2I0A809_9ASPA Unreviewed; 672 AA.
AC A0A2I0A809;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 08-NOV-2023, entry version 16.
DE SubName: Full=Putative rhamnose biosynthetic enzyme 1 {ECO:0000313|EMBL:PKA51676.1};
DE EC=4.2.1.76 {ECO:0000313|EMBL:PKA51676.1};
GN Name=RHM1 {ECO:0000313|EMBL:PKA51676.1};
GN ORFNames=AXF42_Ash003043 {ECO:0000313|EMBL:PKA51676.1};
OS Apostasia shenzhenica.
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Asparagales; Orchidaceae;
OC Apostasioideae; Apostasia.
OX NCBI_TaxID=1088818 {ECO:0000313|EMBL:PKA51676.1, ECO:0000313|Proteomes:UP000236161};
RN [1] {ECO:0000313|EMBL:PKA51676.1, ECO:0000313|Proteomes:UP000236161}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Shenzhen {ECO:0000313|Proteomes:UP000236161};
RC TISSUE=Stem {ECO:0000313|EMBL:PKA51676.1};
RX PubMed=28902843; DOI=10.1038/nature23897;
RA Zhang G.Q., Liu K.W., Li Z., Lohaus R., Hsiao Y.Y., Niu S.C., Wang J.Y.,
RA Lin Y.C., Xu Q., Chen L.J., Yoshida K., Fujiwara S., Wang Z.W., Zhang Y.Q.,
RA Mitsuda N., Wang M., Liu G.H., Pecoraro L., Huang H.X., Xiao X.J., Lin M.,
RA Wu X.Y., Wu W.L., Chen Y.Y., Chang S.B., Sakamoto S., Ohme-Takagi M.,
RA Yagi M., Zeng S.J., Shen C.Y., Yeh C.M., Luo Y.B., Tsai W.C.,
RA Van de Peer Y., Liu Z.J.;
RT "The Apostasia genome and the evolution of orchids.";
RL Nature 549:379-383(2017).
CC -!- COFACTOR:
CC Name=NAD(+); Xref=ChEBI:CHEBI:57540;
CC Evidence={ECO:0000256|ARBA:ARBA00001911};
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DR EMBL; KZ452013; PKA51676.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2I0A809; -.
DR STRING; 1088818.A0A2I0A809; -.
DR OrthoDB; 5486426at2759; -.
DR Proteomes; UP000236161; Unassembled WGS sequence.
DR GO; GO:0008460; F:dTDP-glucose 4,6-dehydratase activity; IEA:InterPro.
DR GO; GO:0050377; F:UDP-glucose 4,6-dehydratase activity; IEA:UniProtKB-EC.
DR GO; GO:0009225; P:nucleotide-sugar metabolic process; IEA:InterPro.
DR CDD; cd05246; dTDP_GD_SDR_e; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR Gene3D; 3.90.25.10; UDP-galactose 4-epimerase, domain 1; 1.
DR InterPro; IPR005888; dTDP_Gluc_deHydtase.
DR InterPro; IPR016040; NAD(P)-bd_dom.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR029903; RmlD-like-bd.
DR PANTHER; PTHR43000:SF7; DTDP-D-GLUCOSE 4,6-DEHYDRATASE; 1.
DR PANTHER; PTHR43000; DTDP-D-GLUCOSE 4,6-DEHYDRATASE-RELATED; 1.
DR Pfam; PF16363; GDP_Man_Dehyd; 1.
DR Pfam; PF04321; RmlD_sub_bind; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
PE 4: Predicted;
KW Lyase {ECO:0000313|EMBL:PKA51676.1}; NAD {ECO:0000256|ARBA:ARBA00023027};
KW Reference proteome {ECO:0000313|Proteomes:UP000236161}.
FT DOMAIN 10..315
FT /note="NAD(P)-binding"
FT /evidence="ECO:0000259|Pfam:PF16363"
FT DOMAIN 389..558
FT /note="RmlD-like substrate binding"
FT /evidence="ECO:0000259|Pfam:PF04321"
SQ SEQUENCE 672 AA; 75640 MW; 2A443470A2C4B794 CRC64;
MAPYTPKNIL ITGAAGFIAS HVCNRLIRNY PEYKIVVLDK LDYCSNLKNL LPSQSSPNFK
FVKGDIASAD LVNFLLITES IDTIMHFAAQ THVDNSFGNS FEFTKNNIYG THVLLEACKV
TGHVRRFIHV STDEVYGETD AEAVVGNHEA SQLLPTNPYS ATKAGAEMLV MAYGRSYGLP
VITTRGNNVY GPNQFPEKLI PKFILLAMRG KPLPIHGDGS NVRSYLYCED VAEAFEVILH
KGEVGHIYNI GTKKERRVID VAKDICKLFS LDPETVIKFV ENRPFNDQRY FLDDQKLKKL
GWSERTTWEE GLRKTMEWYT SNPDWWGDVA GALLPHPRML MMPGIERQFD GPADVKDMVS
QLMSSANQTR MVVPVSKSSS GSSDKSSLKF LIYGKTGWIG GLLGEICKKH GIPFEYGRGR
LENRSQLQLD IQTVKPTHVF NAAGVTGRPN VDWCESHKPD TIRTNVVGTL NLADVCRENG
LLMMNYATGC IFEYDAAHPE SSGIGFKEDD KPNFAGSFYS KTKAMVEELL KEYDNVCTLR
VRMPISSDLS NPRNFITKIS KYNKVVNIPN SMTVLDELLP LSVEMAKRNC RGIWNFTNPG
VVSHNEILEM YKKYIDPKFT WVNFTLEEQA KVIVAPRSNN EMDASKLKIE FPGLLSIKES
LVKFVFEPNR KP
//
