ID A0A2I0AYB8_9ASPA Unreviewed; 977 AA.
AC A0A2I0AYB8;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE RecName: Full=Protein HIRA {ECO:0000256|RuleBase:RU364014};
GN ORFNames=AXF42_Ash017949 {ECO:0000313|EMBL:PKA60543.1};
OS Apostasia shenzhenica.
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Asparagales; Orchidaceae;
OC Apostasioideae; Apostasia.
OX NCBI_TaxID=1088818 {ECO:0000313|EMBL:PKA60543.1, ECO:0000313|Proteomes:UP000236161};
RN [1] {ECO:0000313|EMBL:PKA60543.1, ECO:0000313|Proteomes:UP000236161}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Shenzhen {ECO:0000313|Proteomes:UP000236161};
RC TISSUE=Stem {ECO:0000313|EMBL:PKA60543.1};
RX PubMed=28902843; DOI=10.1038/nature23897;
RA Zhang G.Q., Liu K.W., Li Z., Lohaus R., Hsiao Y.Y., Niu S.C., Wang J.Y.,
RA Lin Y.C., Xu Q., Chen L.J., Yoshida K., Fujiwara S., Wang Z.W., Zhang Y.Q.,
RA Mitsuda N., Wang M., Liu G.H., Pecoraro L., Huang H.X., Xiao X.J., Lin M.,
RA Wu X.Y., Wu W.L., Chen Y.Y., Chang S.B., Sakamoto S., Ohme-Takagi M.,
RA Yagi M., Zeng S.J., Shen C.Y., Yeh C.M., Luo Y.B., Tsai W.C.,
RA Van de Peer Y., Liu Z.J.;
RT "The Apostasia genome and the evolution of orchids.";
RL Nature 549:379-383(2017).
CC -!- FUNCTION: Required for replication-independent chromatin assembly and
CC for the periodic repression of histone gene transcription during the
CC cell cycle. {ECO:0000256|RuleBase:RU364014}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU364014}.
CC -!- SIMILARITY: Belongs to the WD repeat HIR1 family.
CC {ECO:0000256|ARBA:ARBA00007306, ECO:0000256|RuleBase:RU364014}.
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DR EMBL; KZ451937; PKA60543.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2I0AYB8; -.
DR STRING; 1088818.A0A2I0AYB8; -.
DR OrthoDB; 5478541at2759; -.
DR Proteomes; UP000236161; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006338; P:chromatin remodeling; IEA:InterPro.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR031120; HIR1-like.
DR InterPro; IPR011494; HIRA-like_C.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR13831; MEMBER OF THE HIR1 FAMILY OF WD-REPEAT PROTEINS; 1.
DR PANTHER; PTHR13831:SF0; PROTEIN HIRA; 1.
DR Pfam; PF07569; Hira; 1.
DR Pfam; PF00400; WD40; 5.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50960; TolB, C-terminal domain; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 4.
DR PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE 3: Inferred from homology;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853,
KW ECO:0000256|RuleBase:RU364014}; Nucleus {ECO:0000256|RuleBase:RU364014};
KW Reference proteome {ECO:0000313|Proteomes:UP000236161};
KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|RuleBase:RU364014};
KW Repressor {ECO:0000256|RuleBase:RU364014};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU364014};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU364014};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT REPEAT 9..44
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 61..102
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 120..161
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 162..203
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 698..897
FT /note="Protein HIRA-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF07569"
FT REGION 418..485
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 418..448
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 977 AA; 107425 MW; 7ABFEFB1D4700D7C CRC64;
MITEKPGWIK HEGMQIFSID IQTGSLRFAT GGGDHKVRIW NMKSVGRGTD CDQSQRLLAT
LWDHFGSVNC VRWAKHGRYL ASGSDDQVIL VYERKPGSGT TEFGSGQPPD VENWKVAMTL
RGHTADVVDL NWSPDDLILA SGSLDNTIHI WNIANGICTA VLRGHSSLVK GVSWDPIGTF
IASQSDDKTV IIWRTSDWSL AHRTDGHWAK SIGSTFFRRL GWSPCGHFIT TTHGFQKPRH
SAPVLERGEW SATFDFLGHN APIIVVKFNH SMFRKHYSNG QDMKAASTGW SNGTSKNTAK
EHQPYNVIAI GSQDRTITVW TTASARPLFV AKHFFMQSVV DLSWSSDGYA LFACSLDGTV
ATFHFEVTEL GQRLTDTELD DLKRSRYGDV RGRQANVAES PAQLLLEAVA AKQYASRKGT
PSLQQSQQVK PTIDPVNPID SQSTVYTPEV PAEEAKKDAM SGNDSLNKAA SGRISSPVKQ
REYRRADGRK RIIPEALGVS SHQVNIGSAA QARVVDLSSL TSDQLKDDHG LIPGEVGNGA
PSFKKQYNAS SDVTNPSGRC NNCGSKERSG ITARANIHES LLITKSPSLM EPSGLVGMPA
SPTSCNAISI RVFNNKDNDD SFPTCFEAKP VEHSVNDMVY HGFGNASLTK ETEISCRKGP
QTLWSDRISG KVTVLAGNAN FWAVGCEDGC LQVYTKCGRR SIPAMMMGSA AVFIDCDECW
KLLVVTKRGL MYVWDLFNKI CILNDSLASL VSSREDASSK DAGSIRVISA RFSKSGSPLV
VLATRHAFLY DLNLKCWLRI ADDCFPASNF ASSFSLNSIH SGELGNLQVD VGKFMARKPT
WTRVTDDGVQ TRAHLETQLA SALVLKSPNE YRQCLLAYIR FLAREADESR LREVCESFLG
PPTGMAEAAF SDTKTWDPCV LGMKKHKLLR EDILPAMASN RKVQRLLNEF MDLLSEYDFD
ANCDQVEVTA AVKDATS
//
