ID A0A2I0FWL1_9GAMM Unreviewed; 1047 AA.
AC A0A2I0FWL1;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE SubName: Full=CusA/CzcA family heavy metal efflux RND transporter {ECO:0000313|EMBL:PKH23799.1};
GN ORFNames=CIG19_10290 {ECO:0000313|EMBL:PKH23799.1};
OS Enterobacterales bacterium CwR94.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales.
OX NCBI_TaxID=2025587 {ECO:0000313|EMBL:PKH23799.1, ECO:0000313|Proteomes:UP000237543};
RN [1] {ECO:0000313|EMBL:PKH23799.1, ECO:0000313|Proteomes:UP000237543}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CwR94 {ECO:0000313|EMBL:PKH23799.1,
RC ECO:0000313|Proteomes:UP000237543};
RA de Groot N.N.;
RL Submitted (AUG-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC (TC 2.A.6) family. {ECO:0000256|ARBA:ARBA00010942}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PKH23799.1}.
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DR EMBL; NVXY01000007; PKH23799.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2I0FWL1; -.
DR OrthoDB; 9758757at2; -.
DR Proteomes; UP000237543; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008324; F:monoatomic cation transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 3.30.70.1430; Multidrug efflux transporter AcrB pore domain; 2.
DR Gene3D; 3.30.70.1440; Multidrug efflux transporter AcrB pore domain; 1.
DR Gene3D; 3.30.70.1320; Multidrug efflux transporter AcrB pore domain like; 1.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR027463; AcrB_DN_DC_subdom.
DR InterPro; IPR001036; Acrflvin-R.
DR InterPro; IPR004763; CusA-like.
DR NCBIfam; TIGR00914; 2A0601; 1.
DR PANTHER; PTHR32063; -; 1.
DR PANTHER; PTHR32063:SF24; CATION EFFLUX SYSTEM (ACRB_ACRD_ACRF FAMILY); 1.
DR Pfam; PF00873; ACR_tran; 1.
DR PRINTS; PR00702; ACRIFLAVINRP.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000237543};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 338..357
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 364..384
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 390..411
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 441..461
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 473..500
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 531..550
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 867..886
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 893..912
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 924..944
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 965..984
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 996..1019
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 1047 AA; 113685 MW; 8C8418CB2D6398E4 CRC64;
MLSTLITLSL KFRLLIILLF LAAMGYGVMA YKNVPVDAFP DVTPVQVNVY TEASGLAAED
IEKLFTIPVE SNMAGLPNVE EIRSMSLAGL SYVSINFKDN TDIYLARQWV SEKLQEIGDT
LPAGYPPPVL GSNSSGLGQV FWYTLDAGNS GLNTMELRML QEWTIRMILK TVPGVDDVVS
WGGEEKQYQV TLDPNKMLQY NVTLADVLRV LAGNNRQAGG QSINIGEEQY LVRGYGQLES
LADIAALRVT NAGDRPVSIR DIARVEFTPA VRSGAVTQNG QEVVMGMVLA RINENASQVV
NGVKDKITSV VNTLLPEGVT LKTVYDRTDL VDLALKTAQS ALLEGALLVA IVLFLFLGEL
RSAAIVIIVL PGSMLLAFIL MQYFGLSANL MSLAGLAIGT GMMVDGAVVM VENIHRRLAI
NHARGIKNNL PLQIQEAARE VAAPVAFAIL IIVVVFTPLL TLDGLEGKLF RPMALTISFA
MLGSLILSLT VVPVLSSLWL KPAHENETRI VRWISAGYQP LLNLVLAHRK GTLAITVTAL
LLSLALFPFL GKSFMPQLQE GNLMFRVTSI PSTSLDTTLS LSRKVSAEIR EQFPQVKEVV
ANIGRAEKGE TADVNSMEIL LTLTPRDDWP DNISYAQLAS RIQTVLEQKN PGAQFSATQP
IQMRVDELIS GIRATLALKI YGPDSATLDR LSQQIQGTLA NITGVDELSM ESNKGKPQVV
IRVDREQAAR YGINVSDIMD VVEAGIGGAS VSTITEGAAR IDLVTRFSAP WRESVAAIGA
IPLRGASGQQ IYLSQVADIE RAEGYAFLRR EGLQRYVVLQ MEVEGRDIDG FVKEATQAIE
QNTPLPEGYW STWGGAFENQ QRAMGKLAVI LPLTIGLIFI LLYTAFGTLR HAVLIMANVP
FAMTGGILSL FLSGQYMSVP SSVGFIAVFG VSMLNGIVMV SFFNELRQQG AGIQEAVRLG
AVQRLRPVLI TATVAILGLI PMLLSSGVGA EVQRPLATVV VGGLLTSTAL TLLLLPLFYE
MMETWHLKKT QRHDRPDIEA PSALEKR
//
