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Database: UniProt
Entry: A0A2I0LG77_COLLI
LinkDB: A0A2I0LG77_COLLI
Original site: A0A2I0LG77_COLLI 
ID   A0A2I0LG77_COLLI        Unreviewed;       380 AA.
AC   A0A2I0LG77;
DT   28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 1.
DT   24-JAN-2024, entry version 21.
DE   RecName: Full=Toll-like receptor {ECO:0000256|RuleBase:RU363040};
DE   Flags: Fragment;
GN   ORFNames=A306_00015372 {ECO:0000313|EMBL:PKK16449.1};
OS   Columba livia (Rock dove).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Columbiformes; Columbidae; Columba.
OX   NCBI_TaxID=8932 {ECO:0000313|EMBL:PKK16449.1, ECO:0000313|Proteomes:UP000053872};
RN   [1] {ECO:0000313|EMBL:PKK16449.1, ECO:0000313|Proteomes:UP000053872}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   TISSUE=Blood {ECO:0000313|EMBL:PKK16449.1};
RX   PubMed=23371554; DOI=10.1126/science.1230422;
RA   Shapiro M.D., Kronenberg Z., Li C., Domyan E.T., Pan H., Campbell M.,
RA   Tan H., Huff C.D., Hu H., Vickrey A.I., Nielsen S.C., Stringham S.A.,
RA   Hu H., Willerslev E., Gilbert M.T., Yandell M., Zhang G., Wang J.;
RT   "Genomic diversity and evolution of the head crest in the rock pigeon.";
RL   Science 339:1063-1067(2013).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC       ECO:0000256|RuleBase:RU363040}; Single-pass type I membrane protein
CC       {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU363040}.
CC   -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC       {ECO:0000256|ARBA:ARBA00009634, ECO:0000256|RuleBase:RU363040}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PKK16449.1}.
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DR   EMBL; AKCR02003528; PKK16449.1; -; Genomic_DNA.
DR   RefSeq; XP_005515912.1; XM_005515855.1.
DR   AlphaFoldDB; A0A2I0LG77; -.
DR   STRING; 8932.A0A2I0LG77; -.
DR   GeneID; 102090750; -.
DR   KEGG; clv:102090750; -.
DR   InParanoid; A0A2I0LG77; -.
DR   OrthoDB; 21383at2759; -.
DR   Proteomes; UP000053872; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   GO; GO:0002224; P:toll-like receptor signaling pathway; IEA:InterPro.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR   Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR   InterPro; IPR000483; Cys-rich_flank_reg_C.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR000157; TIR_dom.
DR   InterPro; IPR017241; Toll-like_receptor.
DR   InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR   PANTHER; PTHR24365; TOLL-LIKE RECEPTOR; 1.
DR   PANTHER; PTHR24365:SF422; TOLL-LIKE RECEPTOR 6; 1.
DR   Pfam; PF13516; LRR_6; 1.
DR   Pfam; PF13855; LRR_8; 1.
DR   Pfam; PF01463; LRRCT; 1.
DR   Pfam; PF01582; TIR; 1.
DR   PRINTS; PR01537; INTRLKN1R1F.
DR   PRINTS; PR00019; LEURICHRPT.
DR   SMART; SM00082; LRRCT; 1.
DR   SMART; SM00255; TIR; 1.
DR   SUPFAM; SSF52058; L domain-like; 1.
DR   SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR   PROSITE; PS51450; LRR; 3.
DR   PROSITE; PS50104; TIR; 1.
PE   3: Inferred from homology;
KW   Immunity {ECO:0000256|ARBA:ARBA00022859, ECO:0000256|RuleBase:RU363040};
KW   Inflammatory response {ECO:0000256|ARBA:ARBA00023198,
KW   ECO:0000256|RuleBase:RU363040};
KW   Innate immunity {ECO:0000256|ARBA:ARBA00022588,
KW   ECO:0000256|RuleBase:RU363040}; Membrane {ECO:0000256|RuleBase:RU363040};
KW   Receptor {ECO:0000256|RuleBase:RU363040, ECO:0000313|EMBL:PKK16449.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053872};
KW   Signal {ECO:0000256|ARBA:ARBA00022729};
KW   Transmembrane {ECO:0000256|RuleBase:RU363040};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU363040}.
FT   TRANSMEM        183..207
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363040"
FT   DOMAIN          238..380
FT                   /note="TIR"
FT                   /evidence="ECO:0000259|PROSITE:PS50104"
FT   NON_TER         380
FT                   /evidence="ECO:0000313|EMBL:PKK16449.1"
SQ   SEQUENCE   380 AA;  43492 MW;  D39AADABC4DDF1BF CRC64;
     MKSLKYLDMS SNLLSHDGAD ARCQWAESLS ELDLSSNQLT DVVFECLPVN IKTLNLQNNQ
     IASVPRGVTE LKSLAELNLA SNRLADLPGC SGFSSLEFLN TEMNLILTPS ADFFQSCPRV
     RELQAGHNPF KCSCELQDFL RLERRSGGKL AGWPAAYLCE YPSALRGTQL KDFHLSELAC
     NTALLLVTAL LLTLVLVAVV AFLCIYLDVP WYVRMTWQWT QTKRRAWHSR PEGQETVLQF
     HAFVSYSERD ALWVKNELIP NLEKGEDCVQ LCQHERNFIP GKSIVENIIT CIEKSYKSIF
     VLSPNFVQSE WCHYELYFAH HKLFSENSNS LILILLEPIP PYIIPARYHK LKALMAKRTY
     LEWPKERSKR ALFWANLRAA
//
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