ID A0A2I0LG77_COLLI Unreviewed; 380 AA.
AC A0A2I0LG77;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE RecName: Full=Toll-like receptor {ECO:0000256|RuleBase:RU363040};
DE Flags: Fragment;
GN ORFNames=A306_00015372 {ECO:0000313|EMBL:PKK16449.1};
OS Columba livia (Rock dove).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Columbiformes; Columbidae; Columba.
OX NCBI_TaxID=8932 {ECO:0000313|EMBL:PKK16449.1, ECO:0000313|Proteomes:UP000053872};
RN [1] {ECO:0000313|EMBL:PKK16449.1, ECO:0000313|Proteomes:UP000053872}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Blood {ECO:0000313|EMBL:PKK16449.1};
RX PubMed=23371554; DOI=10.1126/science.1230422;
RA Shapiro M.D., Kronenberg Z., Li C., Domyan E.T., Pan H., Campbell M.,
RA Tan H., Huff C.D., Hu H., Vickrey A.I., Nielsen S.C., Stringham S.A.,
RA Hu H., Willerslev E., Gilbert M.T., Yandell M., Zhang G., Wang J.;
RT "Genomic diversity and evolution of the head crest in the rock pigeon.";
RL Science 339:1063-1067(2013).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU363040}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU363040}.
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634, ECO:0000256|RuleBase:RU363040}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PKK16449.1}.
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DR EMBL; AKCR02003528; PKK16449.1; -; Genomic_DNA.
DR RefSeq; XP_005515912.1; XM_005515855.1.
DR AlphaFoldDB; A0A2I0LG77; -.
DR STRING; 8932.A0A2I0LG77; -.
DR GeneID; 102090750; -.
DR KEGG; clv:102090750; -.
DR InParanoid; A0A2I0LG77; -.
DR OrthoDB; 21383at2759; -.
DR Proteomes; UP000053872; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0002224; P:toll-like receptor signaling pathway; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR017241; Toll-like_receptor.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR24365; TOLL-LIKE RECEPTOR; 1.
DR PANTHER; PTHR24365:SF422; TOLL-LIKE RECEPTOR 6; 1.
DR Pfam; PF13516; LRR_6; 1.
DR Pfam; PF13855; LRR_8; 1.
DR Pfam; PF01463; LRRCT; 1.
DR Pfam; PF01582; TIR; 1.
DR PRINTS; PR01537; INTRLKN1R1F.
DR PRINTS; PR00019; LEURICHRPT.
DR SMART; SM00082; LRRCT; 1.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS51450; LRR; 3.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Immunity {ECO:0000256|ARBA:ARBA00022859, ECO:0000256|RuleBase:RU363040};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198,
KW ECO:0000256|RuleBase:RU363040};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588,
KW ECO:0000256|RuleBase:RU363040}; Membrane {ECO:0000256|RuleBase:RU363040};
KW Receptor {ECO:0000256|RuleBase:RU363040, ECO:0000313|EMBL:PKK16449.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000053872};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|RuleBase:RU363040};
KW Transmembrane helix {ECO:0000256|RuleBase:RU363040}.
FT TRANSMEM 183..207
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363040"
FT DOMAIN 238..380
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
FT NON_TER 380
FT /evidence="ECO:0000313|EMBL:PKK16449.1"
SQ SEQUENCE 380 AA; 43492 MW; D39AADABC4DDF1BF CRC64;
MKSLKYLDMS SNLLSHDGAD ARCQWAESLS ELDLSSNQLT DVVFECLPVN IKTLNLQNNQ
IASVPRGVTE LKSLAELNLA SNRLADLPGC SGFSSLEFLN TEMNLILTPS ADFFQSCPRV
RELQAGHNPF KCSCELQDFL RLERRSGGKL AGWPAAYLCE YPSALRGTQL KDFHLSELAC
NTALLLVTAL LLTLVLVAVV AFLCIYLDVP WYVRMTWQWT QTKRRAWHSR PEGQETVLQF
HAFVSYSERD ALWVKNELIP NLEKGEDCVQ LCQHERNFIP GKSIVENIIT CIEKSYKSIF
VLSPNFVQSE WCHYELYFAH HKLFSENSNS LILILLEPIP PYIIPARYHK LKALMAKRTY
LEWPKERSKR ALFWANLRAA
//