ID A0A2I0LI66_COLLI Unreviewed; 868 AA.
AC A0A2I0LI66;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE RecName: Full=phosphoinositide 5-phosphatase {ECO:0000256|ARBA:ARBA00013044};
DE EC=3.1.3.36 {ECO:0000256|ARBA:ARBA00013044};
GN Name=OCRL {ECO:0000313|EMBL:PKK17131.1};
GN ORFNames=A306_00014803 {ECO:0000313|EMBL:PKK17131.1};
OS Columba livia (Rock dove).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Columbiformes; Columbidae; Columba.
OX NCBI_TaxID=8932 {ECO:0000313|EMBL:PKK17131.1, ECO:0000313|Proteomes:UP000053872};
RN [1] {ECO:0000313|EMBL:PKK17131.1, ECO:0000313|Proteomes:UP000053872}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Blood {ECO:0000313|EMBL:PKK17131.1};
RX PubMed=23371554; DOI=10.1126/science.1230422;
RA Shapiro M.D., Kronenberg Z., Li C., Domyan E.T., Pan H., Campbell M.,
RA Tan H., Huff C.D., Hu H., Vickrey A.I., Nielsen S.C., Stringham S.A.,
RA Hu H., Willerslev E., Gilbert M.T., Yandell M., Zhang G., Wang J.;
RT "Genomic diversity and evolution of the head crest in the rock pigeon.";
RL Science 339:1063-1067(2013).
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, phagosome membrane
CC {ECO:0000256|ARBA:ARBA00004580}. Early endosome membrane
CC {ECO:0000256|ARBA:ARBA00004146}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004608}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}.
CC -!- SIMILARITY: Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase
CC type II family. {ECO:0000256|ARBA:ARBA00005910}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PKK17131.1}.
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DR EMBL; AKCR02000426; PKK17131.1; -; Genomic_DNA.
DR RefSeq; XP_013223019.1; XM_013367565.1.
DR AlphaFoldDB; A0A2I0LI66; -.
DR STRING; 8932.A0A2I0LI66; -.
DR InParanoid; A0A2I0LI66; -.
DR Proteomes; UP000053872; Unassembled WGS sequence.
DR GO; GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030670; C:phagocytic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0052745; F:inositol phosphate phosphatase activity; IEA:InterPro.
DR GO; GO:0004439; F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0046856; P:phosphatidylinositol dephosphorylation; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd09093; INPP5c_INPP5B; 1.
DR CDD; cd04380; RhoGAP_OCRL1; 1.
DR Gene3D; 2.30.29.110; -; 1.
DR Gene3D; 3.60.10.10; Endonuclease/exonuclease/phosphatase; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR046985; IP5.
DR InterPro; IPR000300; IPPc.
DR InterPro; IPR048869; OCRL-1_2_ASH.
DR InterPro; IPR037793; OCRL1/INPP5B_INPP5c.
DR InterPro; IPR031995; OCRL_clath-bd.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR047078; RhoGAP_OCRL1.
DR PANTHER; PTHR11200; INOSITOL 5-PHOSPHATASE; 1.
DR PANTHER; PTHR11200:SF176; INOSITOL POLYPHOSPHATE 5-PHOSPHATASE OCRL; 1.
DR Pfam; PF21310; OCRL-like_ASH; 1.
DR Pfam; PF16726; OCRL_clath_bd; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00128; IPPc; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF56219; DNase I-like; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 3: Inferred from homology;
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Reference proteome {ECO:0000313|Proteomes:UP000053872}.
FT DOMAIN 687..868
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 132..168
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 868 AA; 100272 MW; 1510F68031C4300C CRC64;
MPVVQVVIHS QEKENSDPDY IPINSRFKCV QEAEETLLID IATNTGCKVR IQGDKTAERL
FEIPDEERCL GFLSEVQSIQ EAQLKASLPE PKDSDTWHQV EKNLPGLSQD SLGALEFEDD
FNALSLEEKR NMQNHQTGSR REPPPPPVPQ NRQFHREREG TSRDQPKVTN TMRKMFLPST
QSGQREGLIR HVLAKREEAY VNLHNFRFFV GTWNVNGQSP DGSLEPWLVC DAEPPDFYCI
GFQELDLSTE AFFYFDSAKE QEWLAAVEKA LHPQAKYKKV QMVRLVGMML LVFAKKGHLS
NIREIMTESV GTGIMGKMGN KGGVAVRFVF HNTTFCVVNS HLAAHVEDFE RRNQDYKDIC
ARMSFVTPDD SLPQLNIMKH DVVIWLGDLN YRLCLPDANE VKSLISKNEL QKLLTYDQLN
IQRIHKKAFA DFTEGEIKFI PTYKYDSKTD RWDSSGKCRV PAWCDRILWR GGNINQLRYC
SHMELKTSDH KPVSALFRIG VKVVDEQKYR KLFEDIVRMM DRMENDFLPS LELSRREFEF
ENVKFRQLQK QKFQITNNGQ VTCHFSFIPK LNDTHYCKPW LRAEPCEGYL EPDESTDISL
DVYVSKDSVT LLNSGEDKIE DILVLHLDRG KDYFLTISGT YLPSCFGTSL EALCRMRRPI
REVPVTKLID LGEDNFLEKE KSILQMGSLD SEDASEMPLQ VPKEIWLLVD HLFKHACHQE
DLFQTPGMQE ELEQIIDCLD TSIPETIPGS NHSVAEALLI FLEALPEPVI CYELYQRCLD
WSHNSRLCRQ VIFQLPRCHR SVFRYLMSFL RELLKYSEDN NVSVAMIAAL FSSLLLRPPP
NLMAKQTQQD RQRAINFLYS FLLAGDEE
//
