ID A0A2I0LIG5_COLLI Unreviewed; 350 AA.
AC A0A2I0LIG5;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=TNF receptor-associated factor 2 {ECO:0000313|EMBL:PKK17224.1};
GN Name=TRAF2 {ECO:0000313|EMBL:PKK17224.1};
GN ORFNames=A306_00014674 {ECO:0000313|EMBL:PKK17224.1};
OS Columba livia (Rock dove).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Columbiformes; Columbidae; Columba.
OX NCBI_TaxID=8932 {ECO:0000313|EMBL:PKK17224.1, ECO:0000313|Proteomes:UP000053872};
RN [1] {ECO:0000313|EMBL:PKK17224.1, ECO:0000313|Proteomes:UP000053872}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Blood {ECO:0000313|EMBL:PKK17224.1};
RX PubMed=23371554; DOI=10.1126/science.1230422;
RA Shapiro M.D., Kronenberg Z., Li C., Domyan E.T., Pan H., Campbell M.,
RA Tan H., Huff C.D., Hu H., Vickrey A.I., Nielsen S.C., Stringham S.A.,
RA Hu H., Willerslev E., Gilbert M.T., Yandell M., Zhang G., Wang J.;
RT "Genomic diversity and evolution of the head crest in the rock pigeon.";
RL Science 339:1063-1067(2013).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PKK17224.1}.
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DR EMBL; AKCR02000383; PKK17224.1; -; Genomic_DNA.
DR RefSeq; XP_005513258.1; XM_005513201.1.
DR AlphaFoldDB; A0A2I0LIG5; -.
DR STRING; 8932.A0A2I0LIG5; -.
DR InParanoid; A0A2I0LIG5; -.
DR Proteomes; UP000053872; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:InterPro.
DR GO; GO:0005164; F:tumor necrosis factor receptor binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR GO; GO:0033209; P:tumor necrosis factor-mediated signaling pathway; IEA:InterPro.
DR CDD; cd16639; RING-HC_TRAF2; 1.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR002083; MATH/TRAF_dom.
DR InterPro; IPR012227; TNF_rcpt-assoc_TRAF_met.
DR InterPro; IPR008974; TRAF-like.
DR InterPro; IPR027133; TRAF2_RING-HC.
DR InterPro; IPR049441; TRAF2_Znf.
DR InterPro; IPR032070; TRAF_BIRC3-bd.
DR InterPro; IPR049342; TRAF_MEP1_MATH_dom.
DR InterPro; IPR018957; Znf_C3HC4_RING-type.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR10131; TNF RECEPTOR ASSOCIATED FACTOR; 1.
DR PANTHER; PTHR10131:SF21; TNF RECEPTOR-ASSOCIATED FACTOR 2; 1.
DR Pfam; PF21355; TRAF-mep_MATH; 1.
DR Pfam; PF21341; TRAF2_zf; 1.
DR Pfam; PF16673; TRAF_BIRC3_bd; 1.
DR Pfam; PF00097; zf-C3HC4; 1.
DR PIRSF; PIRSF015614; TRAF; 2.
DR SMART; SM00061; MATH; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR SUPFAM; SSF49599; TRAF domain-like; 2.
DR SUPFAM; SSF57953; Trimerization domain of TRAF; 1.
DR PROSITE; PS50144; MATH; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Receptor {ECO:0000313|EMBL:PKK17224.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000053872};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 34..72
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 200..345
FT /note="MATH"
FT /evidence="ECO:0000259|PROSITE:PS50144"
SQ SEQUENCE 350 AA; 39247 MW; A7DB05C051D99954 CRC64;
MAAANSTPPG SLDLNQPGFA KEILGTKLEV KYLCSDCKNI LRRPFQAQCG HRYCSYCLKK
IISAGPQKCA SCIQEGIYEE GISILETSSA FPDNAARREV ESLPAVCINS GCTWKGTIKE
YEAHDEVCPE FPLTCEGCGK KVPREKVPTE AYSRQHRLDQ EKIETLSNKV RQLERSIGLK
DLAMAEMEEK IRNMEASTYD GVFIWKITEF ARKRQEAITG RSPAIFSPAF YTSKYGYKMC
LRVYLNGDGT GRGTHLSLFF VVMKGPNDAL LRWPFNQKVT LMLLDQNNRE HIIDAFRPDV
TSSSFQRPVT EMNIASGCPL FCPVSVMEAK NSYVRDDAIF IKAIVDLTGL
//
