ID A0A2I0LIS3_COLLI Unreviewed; 679 AA.
AC A0A2I0LIS3;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 24-JAN-2024, entry version 16.
DE SubName: Full=EWS RNA-binding protein 1 {ECO:0000313|EMBL:PKK17330.1};
DE Flags: Fragment;
GN Name=EWSR1 {ECO:0000313|EMBL:PKK17330.1};
GN ORFNames=A306_00014623 {ECO:0000313|EMBL:PKK17330.1};
OS Columba livia (Rock dove).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Columbiformes; Columbidae; Columba.
OX NCBI_TaxID=8932 {ECO:0000313|EMBL:PKK17330.1, ECO:0000313|Proteomes:UP000053872};
RN [1] {ECO:0000313|EMBL:PKK17330.1, ECO:0000313|Proteomes:UP000053872}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Blood {ECO:0000313|EMBL:PKK17330.1};
RX PubMed=23371554; DOI=10.1126/science.1230422;
RA Shapiro M.D., Kronenberg Z., Li C., Domyan E.T., Pan H., Campbell M.,
RA Tan H., Huff C.D., Hu H., Vickrey A.I., Nielsen S.C., Stringham S.A.,
RA Hu H., Willerslev E., Gilbert M.T., Yandell M., Zhang G., Wang J.;
RT "Genomic diversity and evolution of the head crest in the rock pigeon.";
RL Science 339:1063-1067(2013).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the RRM TET family.
CC {ECO:0000256|ARBA:ARBA00008448}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PKK17330.1}.
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DR EMBL; AKCR02000346; PKK17330.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2I0LIS3; -.
DR STRING; 8932.A0A2I0LIS3; -.
DR InParanoid; A0A2I0LIS3; -.
DR Proteomes; UP000053872; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd12533; RRM_EWS; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR Gene3D; 4.10.1060.10; Zinc finger, RanBP2-type; 1.
DR InterPro; IPR034869; EWS_RRM.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR InterPro; IPR034870; TET_fam.
DR InterPro; IPR001876; Znf_RanBP2.
DR InterPro; IPR036443; Znf_RanBP2_sf.
DR PANTHER; PTHR23238; RNA BINDING PROTEIN; 1.
DR PANTHER; PTHR23238:SF3; RNA-BINDING PROTEIN EWS; 1.
DR Pfam; PF00076; RRM_1; 1.
DR Pfam; PF00641; zf-RanBP; 1.
DR SMART; SM00360; RRM; 1.
DR SMART; SM00547; ZnF_RBZ; 1.
DR SUPFAM; SSF90209; Ran binding protein zinc finger-like; 1.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
DR PROSITE; PS50102; RRM; 1.
DR PROSITE; PS01358; ZF_RANBP2_1; 1.
DR PROSITE; PS50199; ZF_RANBP2_2; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000053872};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU00176}; Signal {ECO:0000256|SAM:SignalP};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00322}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..679
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014193188"
FT DOMAIN 371..457
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 533..564
FT /note="RanBP2-type"
FT /evidence="ECO:0000259|PROSITE:PS50199"
FT REGION 132..372
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 454..541
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 565..679
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 152..187
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 189..203
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 204..244
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 255..305
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 471..494
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 660..679
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:PKK17330.1"
SQ SEQUENCE 679 AA; 70826 MW; 3F477BA6ED4FC270 CRC64;
FVNVFVFLFP FLVDYSTYSQ AAAQQGYSAY APQPAQGYAQ TTQTYGQQSY GTYGQPTDVS
YTQPQTTATY GQTAYATSYG QPPTGYTAPT APPAYSQPVQ GYGTAAYDTN TATVTTTQAS
YAAPSAYGTQ PAYPAYGQQP TAPAPARPQD GSKPAETSQP QSSTTGYSQP SLGYGQSNYS
YPQVPASYPM QPVTAPPSYP PTSYSSSQPS SYDQSTYSQQ STYGQQSTYG QQTSYGQQSS
YGQQPPPTSY PPPTGSYSQA PSQYSQQSSS YGQQSSFRQD HPSSMNVYGQ DSGGFSGSGE
NRNMSGPDNR GRGRGGYDRG GMSRGGRGGG RGGMGSAGER GGFNKPGGHM EEGPDLDLGP
PMDPDEDSDN SSVYVQGLND NVTLEDLADF FKQCGVVKMN KRTGQPMINL YINKETGKPK
GDAMVSYDDP STAKTAVEWF DGKDFQGNKL KVSLARKKGP MNTMRGGMPP REPRGMPPPL
RGGPGGPGGP GGPSGPSGPM GRMGGRGGER GGFSSRGPRG SRGNPSGGSV QHRAGDWQCP
NPGCGNQNFS WRTECNQCKA PKPEGFLPPP FPPPGGDRGR GGPGGMRGGR GGGLMDRGGP
GGMFRGGRGG DRGGFRGGRG MDRGGYGGGG RRGGGGGGPG GPPGPLMEQM GGGGRGGRRG
GPGKMDKGEH RQERRDRPY
//
