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Database: UniProt
Entry: A0A2I0LNA9_COLLI
LinkDB: A0A2I0LNA9_COLLI
Original site: A0A2I0LNA9_COLLI 
ID   A0A2I0LNA9_COLLI        Unreviewed;       394 AA.
AC   A0A2I0LNA9;
DT   28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 1.
DT   31-JUL-2019, entry version 10.
DE   SubName: Full=G protein-activated inward rectifier potassium channel 1-like {ECO:0000313|EMBL:PKK18912.1};
DE   Flags: Fragment;
GN   ORFNames=A306_00011900 {ECO:0000313|EMBL:PKK18912.1};
OS   Columba livia (Rock dove).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Columbiformes; Columbidae; Columba.
OX   NCBI_TaxID=8932 {ECO:0000313|EMBL:PKK18912.1, ECO:0000313|Proteomes:UP000053872};
RN   [1] {ECO:0000313|EMBL:PKK18912.1, ECO:0000313|Proteomes:UP000053872}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   TISSUE=Blood {ECO:0000313|EMBL:PKK18912.1};
RX   PubMed=23371554; DOI=10.1126/science.1230422;
RA   Shapiro M.D., Kronenberg Z., Li C., Domyan E.T., Pan H., Campbell M.,
RA   Tan H., Huff C.D., Hu H., Vickrey A.I., Nielsen S.C., Stringham S.A.,
RA   Hu H., Willerslev E., Gilbert M.T., Yandell M., Zhang G., Wang J.;
RT   "Genomic diversity and evolution of the head crest in the rock
RT   pigeon.";
RL   Science 339:1063-1067(2013).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003822};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003822}.
CC   -!- SIMILARITY: Belongs to the inward rectifier-type potassium channel
CC       (TC 1.A.2.1) family. {ECO:0000256|RuleBase:RU003822}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:PKK18912.1}.
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DR   EMBL; AKCR02000175; PKK18912.1; -; Genomic_DNA.
DR   RefSeq; XP_005513624.1; XM_005513567.1.
DR   GeneID; 102086370; -.
DR   KEGG; clv:102086370; -.
DR   Proteomes; UP000053872; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015467; F:G-protein activated inward rectifier potassium channel activity; IEA:InterPro.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.1400; -; 1.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR041647; IRK_C.
DR   InterPro; IPR016449; K_chnl_inward-rec_Kir.
DR   InterPro; IPR003274; K_chnl_inward-rec_Kir3.1.
DR   InterPro; IPR013518; K_chnl_inward-rec_Kir_cyto.
DR   InterPro; IPR040445; Kir_TM.
DR   PANTHER; PTHR11767; PTHR11767; 1.
DR   Pfam; PF01007; IRK; 1.
DR   Pfam; PF17655; IRK_C; 1.
DR   PIRSF; PIRSF005465; GIRK_kir; 1.
DR   PRINTS; PR01327; KIR31CHANNEL.
DR   PRINTS; PR01320; KIRCHANNEL.
DR   SUPFAM; SSF81296; SSF81296; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000053872};
KW   Ion channel {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434609, ECO:0000313|EMBL:PKK18912.1};
KW   Ion transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434639};
KW   Membrane {ECO:0000256|SAAS:SAAS00434581, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434575};
KW   Potassium transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434641};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053872};
KW   Transmembrane {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434543, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00036756,
KW   ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00036755};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00048561}.
FT   TRANSMEM     50     73       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN        1     78       IRK. {ECO:0000259|Pfam:PF01007}.
FT   DOMAIN       85    255       IRK_C. {ECO:0000259|Pfam:PF17655}.
FT   REGION      247    269       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   COMPBIAS    250    269       Polar. {ECO:0000256|SAM:MobiDB-lite}.
FT   SITE         64     64       Role in the control of polyamine-mediated
FT                                channel gating and in the blocking by
FT                                intracellular magnesium.
FT                                {ECO:0000256|PIRSR:PIRSR005465-1}.
FT   NON_TER       1      1       {ECO:0000313|EMBL:PKK18912.1}.
SQ   SEQUENCE   394 AA;  43680 MW;  7F7943328E3E40A9 CRC64;
     GDLHRAHDDA YSPCVANVYN FPSAFLFFIE TEATIGYGHR YITERCPEGI VLFLFQSLLG
     SIVDAFLIGC MFIKMSQPKK RAETLMFSRA AVVSQRDGKL CLMFRVGNLR NSHMVSAQIR
     CKLIKSRQTP EGEFLPLDQC ELDVGFGTGA DQLFLVSPLT ICHEINSKSP LFCLSQRSLQ
     SEQFEIVVIL EGIVETTGMT CQARTSYTED EVLWGHRFLP VMSLEDGFFH VDYSQFHATF
     EVPTPPYSVK EQEENPSLAS PLSSPVDTNR TRREQVCSLD CIDGTGDKNK LPFKLQKISS
     GKEELPRRAL RMSSSGTEKT CSAGDLLKIQ EVSPSSEGDD RIQLEALKAS AWALSQSTSN
     LGLQKSPPGV CAPDVKLEGN FPAKLQKMDS GHLS
//
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