ID A0A2I0LNC8_COLLI Unreviewed; 708 AA.
AC A0A2I0LNC8;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE SubName: Full=G protein-coupled receptor kinase interacting ArfGAP 1 {ECO:0000313|EMBL:PKK18932.1};
GN Name=GIT1 {ECO:0000313|EMBL:PKK18932.1};
GN ORFNames=A306_00013268 {ECO:0000313|EMBL:PKK18932.1};
OS Columba livia (Rock dove).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Columbiformes; Columbidae; Columba.
OX NCBI_TaxID=8932 {ECO:0000313|EMBL:PKK18932.1, ECO:0000313|Proteomes:UP000053872};
RN [1] {ECO:0000313|EMBL:PKK18932.1, ECO:0000313|Proteomes:UP000053872}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Blood {ECO:0000313|EMBL:PKK18932.1};
RX PubMed=23371554; DOI=10.1126/science.1230422;
RA Shapiro M.D., Kronenberg Z., Li C., Domyan E.T., Pan H., Campbell M.,
RA Tan H., Huff C.D., Hu H., Vickrey A.I., Nielsen S.C., Stringham S.A.,
RA Hu H., Willerslev E., Gilbert M.T., Yandell M., Zhang G., Wang J.;
RT "Genomic diversity and evolution of the head crest in the rock pigeon.";
RL Science 339:1063-1067(2013).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PKK18932.1}.
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DR EMBL; AKCR02000173; PKK18932.1; -; Genomic_DNA.
DR STRING; 8932.A0A2I0LNC8; -.
DR InParanoid; A0A2I0LNC8; -.
DR Proteomes; UP000053872; Unassembled WGS sequence.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0007420; P:brain development; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 1.10.220.150; Arf GTPase activating protein; 1.
DR Gene3D; 1.20.120.330; Nucleotidyltransferases domain 2; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR001164; ArfGAP_dom.
DR InterPro; IPR038508; ArfGAP_dom_sf.
DR InterPro; IPR047161; GIT-like.
DR InterPro; IPR032352; GIT1/2_CC.
DR InterPro; IPR022018; GIT1_C.
DR InterPro; IPR013724; GIT_SHD.
DR PANTHER; PTHR46097:SF1; ARF GTPASE-ACTIVATING PROTEIN GIT1; 1.
DR PANTHER; PTHR46097; G PROTEIN-COUPLED RECEPTOR KINASE INTERACTING ARFGAP; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF12205; GIT1_C; 1.
DR Pfam; PF16559; GIT_CC; 1.
DR Pfam; PF08518; GIT_SHD; 2.
DR SMART; SM00248; ANK; 3.
DR SMART; SM00105; ArfGap; 1.
DR SMART; SM00555; GIT; 2.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Kinase {ECO:0000313|EMBL:PKK18932.1};
KW Receptor {ECO:0000313|EMBL:PKK18932.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000053872};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transferase {ECO:0000313|EMBL:PKK18932.1}.
FT DOMAIN 1..97
FT /note="Arf-GAP"
FT /evidence="ECO:0000259|SMART:SM00105"
FT REPEAT 139..171
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 246..276
FT /note="GIT Spa2 homology (SHD)"
FT /evidence="ECO:0000259|SMART:SM00555"
FT DOMAIN 310..340
FT /note="GIT Spa2 homology (SHD)"
FT /evidence="ECO:0000259|SMART:SM00555"
FT REGION 353..399
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 441..495
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 547..579
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 383..399
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 473..487
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 708 AA; 78689 MW; 0BCFFF96A95FB821 CRC64;
MQVLVRERRG AGSSQYTLNV TLHLRHSPWP ATLLQMVHTL ASNGANSIWE HSLLDPAQVQ
SGRRKANPQD KVHPTKSEFI RAKYQMLAFV HKLPCRDDDG VTAKDLSKQL HSSVRTGNLE
TCLRLLSLGA QANFFHPEKG TTPLHVAAKA GQILQAELLV VYGADPGAPD VNGRTPIDYA
RQAAQHELAE RLVECQYELT DRLAFYLCGR KPDHKNGHYI IPQMADRVRP KCMAQSLDLS
ELAKAAKKKL QALSNRLFEE LAMDVYDEVD RRENDAVWLT TQNHSTLVTE RSAVPFLPVN
PEYSATRNQG RQKLARFNAR EFATLLIDIL GEAKRRQQGK SLLSPTDALD YSLRSQSDLD
DQHDYDSVAS DEDTDQELLR NASRNNRARS MDSSDLSDGP ITLQEYLEVK KALAASEAKV
QQLMKVNNSL SDELRRLQRE IHKLQAENTQ IRQQTGPAHP TPAPSERPEH GHPPGTAPPH
RRDRQAFSMY EPGSALKPFG QPVEELVTRL QPFGTGEVED EALYSMHIPA SVYRIRKGPS
ASSVPFPPSS PLLSCPPDGA RHMSKLDRHG SGTDSDYDNT QAGEALISME GKRFVELSKD
EDFPHELDPL DGELDAGLPS TEDVILKTEQ VTKNIQELLR AAQESKHDSF VPCSEKIHSA
VTEMASLFPK KPALETVRSS LRLPXXAPRA GCRRGLPAPD PAGHPVCL
//
