ID A0A2I0LNN3_COLLI Unreviewed; 339 AA.
AC A0A2I0LNN3;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 24-JAN-2024, entry version 18.
DE RecName: Full=Nuclear transcription factor Y subunit {ECO:0000256|RuleBase:RU367155};
GN Name=NFYA {ECO:0000313|EMBL:PKK19026.1};
GN ORFNames=A306_00013397 {ECO:0000313|EMBL:PKK19026.1};
OS Columba livia (Rock dove).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Columbiformes; Columbidae; Columba.
OX NCBI_TaxID=8932 {ECO:0000313|EMBL:PKK19026.1, ECO:0000313|Proteomes:UP000053872};
RN [1] {ECO:0000313|EMBL:PKK19026.1, ECO:0000313|Proteomes:UP000053872}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Blood {ECO:0000313|EMBL:PKK19026.1};
RX PubMed=23371554; DOI=10.1126/science.1230422;
RA Shapiro M.D., Kronenberg Z., Li C., Domyan E.T., Pan H., Campbell M.,
RA Tan H., Huff C.D., Hu H., Vickrey A.I., Nielsen S.C., Stringham S.A.,
RA Hu H., Willerslev E., Gilbert M.T., Yandell M., Zhang G., Wang J.;
RT "Genomic diversity and evolution of the head crest in the rock pigeon.";
RL Science 339:1063-1067(2013).
CC -!- FUNCTION: Component of the sequence-specific heterotrimeric
CC transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3'
CC box motif found in the promoters of its target genes.
CC {ECO:0000256|RuleBase:RU367155}.
CC -!- SUBUNIT: Heterotrimer. {ECO:0000256|RuleBase:RU367155}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU367155}.
CC -!- SIMILARITY: Belongs to the NFYA/HAP2 subunit family.
CC {ECO:0000256|RuleBase:RU367155}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PKK19026.1}.
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DR EMBL; AKCR02000169; PKK19026.1; -; Genomic_DNA.
DR RefSeq; XP_013226865.1; XM_013371411.1.
DR AlphaFoldDB; A0A2I0LNN3; -.
DR STRING; 8932.A0A2I0LNN3; -.
DR GeneID; 102089598; -.
DR CTD; 4800; -.
DR InParanoid; A0A2I0LNN3; -.
DR OrthoDB; 5490901at2759; -.
DR Proteomes; UP000053872; Unassembled WGS sequence.
DR GO; GO:0016602; C:CCAAT-binding factor complex; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR Gene3D; 6.10.250.2430; -; 1.
DR InterPro; IPR018362; CCAAT-binding_factor_CS.
DR InterPro; IPR001289; NFYA.
DR PANTHER; PTHR12632:SF6; NUCLEAR TRANSCRIPTION FACTOR Y SUBUNIT ALPHA; 1.
DR PANTHER; PTHR12632; TRANSCRIPTION FACTOR NF-Y ALPHA-RELATED; 1.
DR Pfam; PF02045; CBFB_NFYA; 1.
DR PRINTS; PR00616; CCAATSUBUNTB.
DR SMART; SM00521; CBF; 1.
DR PROSITE; PS00686; NFYA_HAP2_1; 1.
DR PROSITE; PS51152; NFYA_HAP2_2; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU367155};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU367155};
KW Reference proteome {ECO:0000313|Proteomes:UP000053872};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU367155};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU367155}.
FT REGION 290..339
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 304..323
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 324..339
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 339 AA; 36067 MW; DCC1F681E2E5B26B CRC64;
MEQYTANSNS STEQIVVQAG QIQQQQQGGV TAVQLQTEAQ VASASGQQVQ TLQVVQGQPL
MVQVSGGQLI TSTGQPIMVQ AVPGGQGQTI MQVPVSGTQG LQQIQLVQPG QIQIQGGQAV
QVQGQQGQTQ QIIIQQPQTA VTAGQTQTQQ QIAVQGQQVA QAAEGQTIVC YFVTVTVPVT
GMITIPAASL AGAQIVQTGA NTNTTSSGQG TVTVTLPVAG NVVNSGGMVM MVPGAGSVPA
IQRIPLPGAE MLEEEPLYVN AKQYHRILKR RQARAKLEAE GKIPKERRKY LHESRHRHAM
ARKRGEGGRF FSPKEKDSPH MQDPSQANEE AMTQMIRVS
//
