ID A0A2I0LPM2_COLLI Unreviewed; 719 AA.
AC A0A2I0LPM2;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Engulfment and cell motility 3, transcript variant X1 {ECO:0000313|EMBL:PKK19385.1};
GN Name=ELMO3 {ECO:0000313|EMBL:PKK19385.1};
GN ORFNames=A306_00012002 {ECO:0000313|EMBL:PKK19385.1};
OS Columba livia (Rock dove).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Columbiformes; Columbidae; Columba.
OX NCBI_TaxID=8932 {ECO:0000313|EMBL:PKK19385.1, ECO:0000313|Proteomes:UP000053872};
RN [1] {ECO:0000313|EMBL:PKK19385.1, ECO:0000313|Proteomes:UP000053872}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Blood {ECO:0000313|EMBL:PKK19385.1};
RX PubMed=23371554; DOI=10.1126/science.1230422;
RA Shapiro M.D., Kronenberg Z., Li C., Domyan E.T., Pan H., Campbell M.,
RA Tan H., Huff C.D., Hu H., Vickrey A.I., Nielsen S.C., Stringham S.A.,
RA Hu H., Willerslev E., Gilbert M.T., Yandell M., Zhang G., Wang J.;
RT "Genomic diversity and evolution of the head crest in the rock pigeon.";
RL Science 339:1063-1067(2013).
CC -!- FUNCTION: Involved in cytoskeletal rearrangements required for
CC phagocytosis of apoptotic cells and cell motility. Acts in association
CC with DOCK1 and CRK. Was initially proposed to be required in complex
CC with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine
CC nucleotide exchange factor (GEF) activity of DOCK1.
CC {ECO:0000256|ARBA:ARBA00024863}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PKK19385.1}.
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DR EMBL; AKCR02000148; PKK19385.1; -; Genomic_DNA.
DR RefSeq; XP_005512685.1; XM_005512628.1.
DR AlphaFoldDB; A0A2I0LPM2; -.
DR STRING; 8932.A0A2I0LPM2; -.
DR GeneID; 102095855; -.
DR KEGG; clv:102095855; -.
DR CTD; 79767; -.
DR InParanoid; A0A2I0LPM2; -.
DR OrthoDB; 4872856at2759; -.
DR Proteomes; UP000053872; Unassembled WGS sequence.
DR GO; GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0006909; P:phagocytosis; IEA:UniProtKB-KW.
DR CDD; cd13359; PH_ELMO1_CED-12; 1.
DR Gene3D; 6.10.250.810; -; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR024574; ELMO_ARM.
DR InterPro; IPR006816; ELMO_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR12771; ENGULFMENT AND CELL MOTILITY; 1.
DR PANTHER; PTHR12771:SF16; ENGULFMENT AND CELL MOTILITY PROTEIN 3; 1.
DR Pfam; PF11841; ELMO_ARM; 1.
DR Pfam; PF04727; ELMO_CED12; 1.
DR Pfam; PF16457; PH_12; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS51335; ELMO; 1.
PE 4: Predicted;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Phagocytosis {ECO:0000256|ARBA:ARBA00022907};
KW Reference proteome {ECO:0000313|Proteomes:UP000053872};
KW SH3-binding {ECO:0000256|ARBA:ARBA00023036}.
FT DOMAIN 307..480
FT /note="ELMO"
FT /evidence="ECO:0000259|PROSITE:PS51335"
SQ SEQUENCE 719 AA; 82931 MW; BAFB9960B54259EF CRC64;
MPPPKDVVKI AIQMVGAIPQ LIELHQTKPL TSVLKDVCDA WSLPNAERYA LQYTDGRQTY
ITESNRREIK NGSILRLTTS PDQEAERLYS GIQSNNSDVK TDSLKKLASL SQDVTFAQEF
INRNGLKQIF YIVEEGNATG EMLAHTLKAF MELMEHDFVS WETLSAAFIR KIVSYVNMNA
VDASVQQLSL SILENMVPTS RLLFELVKKE VTLDRLLTHL QVTNAQLQLK AMALLIALLL
AATDTERRDM MDYLREKNIR QFIHKNIIHS SEPLGDEMAH YLYVLQSVSL NLCERRMRSS
MDPYSQEQRE LLHSLRQTAF ESESEVPASN FSTERRRSLC AKEFRKLGFT NNSNPAEDFR
RAPPGLLALD NMVYFARHTP SAYGRFVLEN SSREDKHECP FARSSIQLTL ILCEILHIGE
PCSETAQAFY PMFFGQDHFF EELFCICIQL VNKTWKEMRA TQEDFDKVLQ VVREQITRTL
SLKPTSLELF KIRVNTLNYS EILKLRQTER LHQEETLAVP VLELRERLKP ELLELIRQQR
LLHLCEGTLF RKISSRRRQD KLWYCRLSPN HKVLHYGDVE EGVHSAPIES LLEKIPVADM
KMLLVGKECP HTKEKSSGKQ NKDVLELAFS LVYDVEEYCL NFVAPTRYEF CLWTDGLNVL
LGKEMTSERM QTDLDVLLSM ELKLRLLDLE NISIPVTPPP IPKPPSNLNF CYDFSHAEQ
//
