ID A0A2I0LPQ8_COLLI Unreviewed; 1385 AA.
AC A0A2I0LPQ8;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE RecName: Full=Enhancer of mRNA-decapping protein 4 {ECO:0000256|ARBA:ARBA00015762};
GN Name=EDC4 {ECO:0000313|EMBL:PKK19404.1};
GN ORFNames=A306_00011997 {ECO:0000313|EMBL:PKK19404.1};
OS Columba livia (Rock dove).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Columbiformes; Columbidae; Columba.
OX NCBI_TaxID=8932 {ECO:0000313|EMBL:PKK19404.1, ECO:0000313|Proteomes:UP000053872};
RN [1] {ECO:0000313|EMBL:PKK19404.1, ECO:0000313|Proteomes:UP000053872}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Blood {ECO:0000313|EMBL:PKK19404.1};
RX PubMed=23371554; DOI=10.1126/science.1230422;
RA Shapiro M.D., Kronenberg Z., Li C., Domyan E.T., Pan H., Campbell M.,
RA Tan H., Huff C.D., Hu H., Vickrey A.I., Nielsen S.C., Stringham S.A.,
RA Hu H., Willerslev E., Gilbert M.T., Yandell M., Zhang G., Wang J.;
RT "Genomic diversity and evolution of the head crest in the rock pigeon.";
RL Science 339:1063-1067(2013).
CC -!- SUBCELLULAR LOCATION: Cytoplasm, P-body
CC {ECO:0000256|ARBA:ARBA00004201}.
CC -!- SIMILARITY: Belongs to the WD repeat EDC4 family.
CC {ECO:0000256|ARBA:ARBA00009639}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PKK19404.1}.
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DR EMBL; AKCR02000148; PKK19404.1; -; Genomic_DNA.
DR RefSeq; XP_013225940.1; XM_013370486.1.
DR STRING; 8932.A0A2I0LPQ8; -.
DR GeneID; 102086999; -.
DR KEGG; clv:102086999; -.
DR CTD; 23644; -.
DR InParanoid; A0A2I0LPQ8; -.
DR OrthoDB; 2911539at2759; -.
DR Proteomes; UP000053872; Unassembled WGS sequence.
DR GO; GO:0000932; C:P-body; IEA:UniProtKB-SubCell.
DR GO; GO:0031087; P:deadenylation-independent decapping of nuclear-transcribed mRNA; IEA:InterPro.
DR Gene3D; 6.10.140.270; -; 1.
DR Gene3D; 1.10.220.100; conserved c-terminal region of ge- 1; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR045152; EDC4-like.
DR InterPro; IPR049404; EDC4_C.
DR InterPro; IPR044938; EDC4_C_sf.
DR InterPro; IPR032401; EDC4_WD40.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR15598; ENHANCER OF MRNA-DECAPPING PROTEIN 4; 1.
DR PANTHER; PTHR15598:SF5; ENHANCER OF MRNA-DECAPPING PROTEIN 4; 1.
DR Pfam; PF21289; EDC4_C; 1.
DR Pfam; PF16529; Ge1_WD40; 1.
DR SMART; SM00320; WD40; 3.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000053872};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 104..431
FT /note="Enhancer of mRNA-decapping protein 4 WD40 repeat
FT region"
FT /evidence="ECO:0000259|Pfam:PF16529"
FT REPEAT 283..316
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 1252..1372
FT /note="Enhancer of mRNA-decapping protein 4 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF21289"
FT REGION 623..681
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 770..938
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 939..966
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 638..664
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 772..788
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 799..817
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 831..875
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1385 AA; 152417 MW; 801C7D4A922CC7EE CRC64;
MKAGSDFSKT LWSGTWFSSV NENQRPSNSY NGDLNGLLVP DPIVAGDGPS LAKPVHRSIS
LGALQEKQVI CLSGDDSSTC IVISAKDVEI VASSDSSITS KARGSNKVKI QPVARYDWEQ
KYYYGNLIAV SNSYLAYAIR AATNGSAMVR VLSVSTAERT LLKGFTGGVA DLAFAHLNSN
QLACLDEAGN LFVWRLAMDK DKIQEEILVN IKRPDNTPLN TSRRIIWCPF IPDDNEESGE
EGSQTLALLH EDRAEVWDLD IIRANNSSWP VEVPSIKEGF IVVKGHSTCL SEGALSPDGT
VLATASHDGF VKFWQIYIEG QDEPRCLHEW KPHDGRPLSC LLFCDNHKKQ DPEVPFWRFL
ITGADQNREL KMWCTVSWTC LQTVRFSPDI FSSMSILPSL KVCLDLSAEY LILSDVQRKV
LYVMELMQNQ EEGKAYFSSI SEFLLTHPVL SFGIQAVSRC RLRHTEVLPA EEENDNLCVE
GAQGSGAVES AAGVLIKLFC VHTKALQDVQ IRFQPLHSPD MSTSMPSHGS HDEFAFPDHM
ADLSTEGLGS EKGSVHGSQP DLRRIADLPV PADFLSLSND AKPKLMTPDA FMTPSASLQQ
IAVSPGSSVS SLTAVTAMSS TSVTDASMPR PSEDLTVSPK MQLDTSLTLS SSSSSLQTSP
RSHSVLIPGL PDKLAPKAPV PVAPGNSSLA LELQEVEPLV VPQASPTRER SPDVISSAST
AMSKDIPEIA SETLQRSFAA APSGLPAEVL EPNHHADSMA SAASALHLLS PRNRHNSEHS
HHSLDMPPVE VDRLNAPSLL ETALTQENAS SDSVVSQPWP AAPDITRETR NSMADSPRDE
VEEKHKSSSY HRHSYHLLQH DSQDASAEQS DHDDEVASLA STSGGFGAKA STQRLPVKDW
KTKVSPRASP KLKRKGKKDD GDVNQSPRSS NNQMTPEFQD ELMCILRSQQ RELSELRQNQ
MELLQRLTDH LDAIQSSLMG HVERVIDSQQ EQEQRRLDRA LTEGQQRNGQ LQEHLSQQLS
QSLSTAVCNR LERTVREEMK KTVPQCISKS MDPVAGQLSN TITAKLTAVE GTLKESITKL
VKSKNLTDSV VRATADTLQG PIQSAYXXXX EKSCQSMFQQ INDTFKQGTQ EYIQQLENHL
KNKKVREQEA RDPLLNQLRQ LISTFQSTTE QLASTIAASV HAEVQHQLHI IVGNLQESIL
AQVQRVIKGE VSLAMKEQQA AVTSSIVQAM RSAAGTPIPS THLDFQSQQT HILQLLQQGH
LNQAFQQALT AADLNLVLYV CETVDTQQVF GQHPCPLSQP VLLSLIQQLS SDLGTRTELK
LNYLEEAVMH LDHSDPITRD HMGSVMNQVR QKLFQFLQVE PHNTLSKPAR RLMIMLQGLV
TPGMS
//
