ID A0A2I0LRJ3_COLLI Unreviewed; 264 AA.
AC A0A2I0LRJ3;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=Ectodysplasin A {ECO:0000313|EMBL:PKK20046.1};
GN Name=EDA {ECO:0000313|EMBL:PKK20046.1};
GN ORFNames=A306_00012719 {ECO:0000313|EMBL:PKK20046.1};
OS Columba livia (Rock dove).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Columbiformes; Columbidae; Columba.
OX NCBI_TaxID=8932 {ECO:0000313|EMBL:PKK20046.1, ECO:0000313|Proteomes:UP000053872};
RN [1] {ECO:0000313|EMBL:PKK20046.1, ECO:0000313|Proteomes:UP000053872}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Blood {ECO:0000313|EMBL:PKK20046.1};
RX PubMed=23371554; DOI=10.1126/science.1230422;
RA Shapiro M.D., Kronenberg Z., Li C., Domyan E.T., Pan H., Campbell M.,
RA Tan H., Huff C.D., Hu H., Vickrey A.I., Nielsen S.C., Stringham S.A.,
RA Hu H., Willerslev E., Gilbert M.T., Yandell M., Zhang G., Wang J.;
RT "Genomic diversity and evolution of the head crest in the rock pigeon.";
RL Science 339:1063-1067(2013).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the tumor necrosis factor family.
CC {ECO:0000256|ARBA:ARBA00008670}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PKK20046.1}.
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DR EMBL; AKCR02000122; PKK20046.1; -; Genomic_DNA.
DR RefSeq; XP_005509422.1; XM_005509365.1.
DR AlphaFoldDB; A0A2I0LRJ3; -.
DR STRING; 8932.A0A2I0LRJ3; -.
DR GeneID; 102088643; -.
DR KEGG; clv:102088643; -.
DR CTD; 1896; -.
DR InParanoid; A0A2I0LRJ3; -.
DR OrthoDB; 5361136at2759; -.
DR Proteomes; UP000053872; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0005164; F:tumor necrosis factor receptor binding; IEA:InterPro.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR Gene3D; 2.60.120.40; -; 1.
DR InterPro; IPR008160; Collagen.
DR InterPro; IPR006052; TNF_dom.
DR InterPro; IPR008983; Tumour_necrosis_fac-like_dom.
DR PANTHER; PTHR15151:SF13; ECTODYSPLASIN-A; 1.
DR PANTHER; PTHR15151; PROTEIN EIGER; 1.
DR Pfam; PF01391; Collagen; 1.
DR Pfam; PF00229; TNF; 1.
DR SUPFAM; SSF49842; TNF-like; 1.
DR PROSITE; PS50049; TNF_2; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000053872}.
FT DOMAIN 128..258
FT /note="TNF family profile"
FT /evidence="ECO:0000259|PROSITE:PS50049"
FT REGION 17..124
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 18..39
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 61..108
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 264 AA; 27863 MW; E09CB36869BDCE86 CRC64;
MEKAVAAKLA LLNFFHPEEK LHVGEEGRRV RRNKRSKGSE GPDGPSSVKN KKKGKKAGPP
GPNGPQGPPG PPGPQGPPGI PGIPGIPGTT VMGPPGPPGP PGPQGPPGLQ GPSGATDKAG
SRDVQPAVVH LQGQGSAIQV KNGGVLNDWS RITMNPKVFK LHARSGELEV LVDGTYFIYS
QVYYINFTDF ASYEVVVDEK PFLQCTRSIE TGKTNFNTCY TAGVCLLKAR QKIAVKMVHA
DISINMSKHT TFFGAIRLGD APAS
//
