ID A0A2I0LSE0_COLLI Unreviewed; 148 AA.
AC A0A2I0LSE0;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE RecName: Full=Gastric inhibitory polypeptide {ECO:0000256|ARBA:ARBA00013490};
DE AltName: Full=Glucose-dependent insulinotropic polypeptide {ECO:0000256|ARBA:ARBA00031537};
GN Name=GIP {ECO:0000313|EMBL:PKK20339.1};
GN ORFNames=A306_00011188 {ECO:0000313|EMBL:PKK20339.1};
OS Columba livia (Rock dove).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Columbiformes; Columbidae; Columba.
OX NCBI_TaxID=8932 {ECO:0000313|EMBL:PKK20339.1, ECO:0000313|Proteomes:UP000053872};
RN [1] {ECO:0000313|EMBL:PKK20339.1, ECO:0000313|Proteomes:UP000053872}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Blood {ECO:0000313|EMBL:PKK20339.1};
RX PubMed=23371554; DOI=10.1126/science.1230422;
RA Shapiro M.D., Kronenberg Z., Li C., Domyan E.T., Pan H., Campbell M.,
RA Tan H., Huff C.D., Hu H., Vickrey A.I., Nielsen S.C., Stringham S.A.,
RA Hu H., Willerslev E., Gilbert M.T., Yandell M., Zhang G., Wang J.;
RT "Genomic diversity and evolution of the head crest in the rock pigeon.";
RL Science 339:1063-1067(2013).
CC -!- FUNCTION: Potent stimulator of insulin secretion and relatively poor
CC inhibitor of gastric acid secretion. {ECO:0000256|ARBA:ARBA00002766}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the glucagon family.
CC {ECO:0000256|ARBA:ARBA00008369}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PKK20339.1}.
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DR EMBL; AKCR02000113; PKK20339.1; -; Genomic_DNA.
DR RefSeq; XP_005508274.1; XM_005508217.1.
DR AlphaFoldDB; A0A2I0LSE0; -.
DR GeneID; 102090960; -.
DR KEGG; clv:102090960; -.
DR CTD; 2695; -.
DR InParanoid; A0A2I0LSE0; -.
DR OrthoDB; 3805553at2759; -.
DR Proteomes; UP000053872; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR GO; GO:0042304; P:regulation of fatty acid biosynthetic process; IEA:InterPro.
DR GO; GO:0050796; P:regulation of insulin secretion; IEA:InterPro.
DR GO; GO:0009749; P:response to glucose; IEA:InterPro.
DR Gene3D; 6.10.250.590; -; 1.
DR InterPro; IPR039078; GIP.
DR InterPro; IPR000532; Glucagon_GIP_secretin_VIP.
DR PANTHER; PTHR15211:SF0; GASTRIC INHIBITORY POLYPEPTIDE; 1.
DR PANTHER; PTHR15211; GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE; 1.
DR Pfam; PF00123; Hormone_2; 1.
DR SMART; SM00070; GLUCA; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000053872};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..148
FT /note="Gastric inhibitory polypeptide"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014152860"
FT DOMAIN 36..62
FT /note="Glucagon / GIP / secretin / VIP family"
FT /evidence="ECO:0000259|SMART:SM00070"
SQ SEQUENCE 148 AA; 16831 MW; DF38A390F0A46D69 CRC64;
MLSVKILSLL LASLGFVLME DNVSGAPSAR PVHRRYSEAT LASDYSRTMD TMLKKNFVEW
LLARREKKSD NIIEPYKREA ESQVAAANGQ RWDLGTQEHK DLFPWLLRAR ENPSFTSLEG
LEGLKDVLTP EILTWLMSTG LCRDTSQM
//
