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Database: UniProt
Entry: A0A2I0LSM4_COLLI
LinkDB: A0A2I0LSM4_COLLI
Original site: A0A2I0LSM4_COLLI 
ID   A0A2I0LSM4_COLLI        Unreviewed;       473 AA.
AC   A0A2I0LSM4;
DT   28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 1.
DT   13-FEB-2019, entry version 5.
DE   RecName: Full=Hyaluronidase {ECO:0000256|RuleBase:RU610713};
DE            EC=3.2.1.35 {ECO:0000256|RuleBase:RU610713};
DE   AltName: Full=Hyaluronoglucosaminidase {ECO:0000256|RuleBase:RU610713};
DE   Flags: Fragment;
GN   Name=HYAL1 {ECO:0000313|EMBL:PKK20431.1};
GN   ORFNames=A306_00010754 {ECO:0000313|EMBL:PKK20431.1};
OS   Columba livia (Rock dove).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Columbiformes; Columbidae; Columba.
OX   NCBI_TaxID=8932 {ECO:0000313|EMBL:PKK20431.1, ECO:0000313|Proteomes:UP000053872};
RN   [1] {ECO:0000313|EMBL:PKK20431.1, ECO:0000313|Proteomes:UP000053872}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   TISSUE=Blood {ECO:0000313|EMBL:PKK20431.1};
RX   PubMed=23371554; DOI=10.1126/science.1230422;
RA   Shapiro M.D., Kronenberg Z., Li C., Domyan E.T., Pan H., Campbell M.,
RA   Tan H., Huff C.D., Hu H., Vickrey A.I., Nielsen S.C., Stringham S.A.,
RA   Hu H., Willerslev E., Gilbert M.T., Yandell M., Zhang G., Wang J.;
RT   "Genomic diversity and evolution of the head crest in the rock
RT   pigeon.";
RL   Science 339:1063-1067(2013).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Random hydrolysis of (1->4)-linkages between N-acetyl-
CC         beta-D-glucosamine and D-glucuronate residues in hyaluronate.;
CC         EC=3.2.1.35; Evidence={ECO:0000256|RuleBase:RU610713};
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 56 family.
CC       {ECO:0000256|RuleBase:RU610713}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:PKK20431.1}.
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DR   EMBL; AKCR02000111; PKK20431.1; -; Genomic_DNA.
DR   Proteomes; UP000053872; Unassembled WGS sequence.
DR   GO; GO:0004415; F:hyalurononglucosaminidase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   Gene3D; 3.20.20.70; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   InterPro; IPR018155; Hyaluronidase.
DR   PANTHER; PTHR11769; PTHR11769; 1.
DR   Pfam; PF01630; Glyco_hydro_56; 1.
DR   PIRSF; PIRSF038193; Hyaluronidase; 1.
DR   PRINTS; PR00846; GLHYDRLASE56.
DR   SUPFAM; SSF51445; SSF51445; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000053872};
KW   Disulfide bond {ECO:0000256|PIRSR:PIRSR038193-3};
KW   Glycosidase {ECO:0000256|RuleBase:RU610713};
KW   Hydrolase {ECO:0000256|RuleBase:RU610713};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053872}.
FT   ACT_SITE    173    173       Proton donor. {ECO:0000256|PIRSR:
FT                                PIRSR038193-1}.
FT   CARBOHYD    388    388       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000256|PIRSR:PIRSR038193-2}.
FT   DISULFID     85    371       {ECO:0000256|PIRSR:PIRSR038193-3}.
FT   DISULFID    249    263       {ECO:0000256|PIRSR:PIRSR038193-3}.
FT   DISULFID    396    407       {ECO:0000256|PIRSR:PIRSR038193-3}.
FT   DISULFID    401    455       {ECO:0000256|PIRSR:PIRSR038193-3}.
FT   DISULFID    457    466       {ECO:0000256|PIRSR:PIRSR038193-3}.
FT   NON_TER       1      1       {ECO:0000313|EMBL:PKK20431.1}.
SQ   SEQUENCE   473 AA;  53004 MW;  4A8E71F59EEB08D2 CRC64;
     HCPGTGLWIN TGPCLGWAKN IEVCSGLSSP EAAPGPSCTA GTMASGWFCC VLLLLLPAPA
     HAGGPGPVLI NRPFVTIWNI PTENCAEKYN VTLNLEVFDV LANDQQFFIG QDITLFYSKE
     LGLLPYYTSE GMPLNGGLPQ NASLEAHLHQ ATWDIKVTLP SPAYSGLAVI DWEKWRPLWI
     RNWDSMDIYR QKSEELVWQQ HPQWSPELVN KTAKQQFEHS ARAFMEHTLQ LGKTLRPDGY
     WGFYGFPDCY NYNFDSLPYT GTCPMVEQQR NAELQWLWES SRALYPSIYL PARLNGTNKV
     LAYVRHRVAE AFAVFNGSIP VLPYSQIAFN CTVNFLSQED LMNTIGESAA QGTAGIVLWG
     SHIYSSSKEM CLRLKDYVEG PLGHYIVNVT ASAELCSQSL CSGQGRCVRR ENKLGFLHLD
     PFRFAIDLQA GKPWLVAQSL EAVDDTIRLA EEFSCQCYNK WQGPRCDTQG FTE
//
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