ID A0A2I0LT24_COLLI Unreviewed; 1323 AA.
AC A0A2I0LT24;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE RecName: Full=SOS1 protein {ECO:0008006|Google:ProtNLM};
DE Flags: Fragment;
GN ORFNames=A306_00011570 {ECO:0000313|EMBL:PKK20579.1};
OS Columba livia (Rock dove).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Columbiformes; Columbidae; Columba.
OX NCBI_TaxID=8932 {ECO:0000313|EMBL:PKK20579.1, ECO:0000313|Proteomes:UP000053872};
RN [1] {ECO:0000313|EMBL:PKK20579.1, ECO:0000313|Proteomes:UP000053872}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Blood {ECO:0000313|EMBL:PKK20579.1};
RX PubMed=23371554; DOI=10.1126/science.1230422;
RA Shapiro M.D., Kronenberg Z., Li C., Domyan E.T., Pan H., Campbell M.,
RA Tan H., Huff C.D., Hu H., Vickrey A.I., Nielsen S.C., Stringham S.A.,
RA Hu H., Willerslev E., Gilbert M.T., Yandell M., Zhang G., Wang J.;
RT "Genomic diversity and evolution of the head crest in the rock pigeon.";
RL Science 339:1063-1067(2013).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PKK20579.1}.
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DR EMBL; AKCR02000106; PKK20579.1; -; Genomic_DNA.
DR RefSeq; XP_005508800.1; XM_005508743.2.
DR STRING; 8932.A0A2I0LT24; -.
DR InParanoid; A0A2I0LT24; -.
DR Proteomes; UP000053872; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd01261; PH_SOS; 1.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 6.10.250.3060; -; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 1.10.20.10; Histone, subunit A; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR009072; Histone-fold.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF168; SON OF SEVENLESS HOMOLOG 1; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF47113; Histone-fold; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000053872}.
FT DOMAIN 204..394
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 447..550
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 601..745
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 784..1023
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 1023..1323
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1095..1135
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1194..1208
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1241..1262
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1296..1311
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:PKK20579.1"
SQ SEQUENCE 1323 AA; 151645 MW; D7C6C04328E00AB8 CRC64;
DASLPGYCYF ESAKEECCKD PWLLLKGSNC DDEVQVQVHP KLSSTEDALQ YVEELILQLL
NTLCQAQPRS FLDVEDRVQK SFPHPIDKWA IADAQSAIEK RKRRNPLSLP VEKIHPLLKE
VLGYKIDHQV SVYIVAVLEY ISADILKLVG NYVRNIRHYE ITKQDIKVAM CADKVLMDMF
NQDVEDLSAL TLSDEEPSTS GEQTYYDLVK SFMAEVRQYI RELNLIIRVF REPYASNSKL
FSSHDVENIF SRISDIHELS VKLLGHIEDT VEMTDEGSPH PLVGSCFEDM AEELAFDPYE
SYAQDILRPG FHDHFLSQLS KPGAAFYLQS IGEGFKEAVQ YVLPRLLLAP VYHCLHYFEL
LKQLEEKSED EEDKECLKQA ITALLNLQSS MERICSKSLA KRRLSESACR FYTQQMKGKQ
LAIKKMNEIQ KNIDGWEGKD IGQCCNEFIM EGTLTRVGAK HERHIFLFDG LMICCKSNHG
QPRLPGASNA EYRLKEKFFM RKVQINDKDD TNEYRHAFEI ILKDENSVIF AAKSAEEKNN
WMAALISLQY RSTLERMLDV TMLQEEKEEQ MRFPNSELYR FAEPDSEENI VFEENMQPKS
GIPIIKAGTV VKLIERLTYH MYADPNFVRT FLTTYRSFCK PQELLSLLIE RFEIPEPEPT
EADRIAMENG DQPISAELKR FRKEYIQPVQ LRVLNVCRHW VEHHFYDFER DADLLHRLEE
FIGTVRGKAM KKWVESITKI INRKKQAQAI GPSHNITFES PPPAIEWHIS KPGHTETFDL
LTLHPIEIAR QLTLLESDFY RAVQPSELVG SVWTKEDKEI NSPNLLKMIR HTTNLTLWFE
KCIVETENLE ERVIVVSRII EILQVFQELN NFNGVLEIVS AMNSAAVYRL DHTFEQIPSR
QKKVLEEAYE LSEDHYKKYL AKLRSINPPC VPFFGIYLTN ILKTEEGNPE FLKRHGKELI
NFSKRRKVAE ITGEIQQYQN QPYCLRVEFD IRRFFENLNP MGNSMETEFT DYLFNKSLEI
EPRNVKPPPR FPKKYSYPLK SPGVRPSNPR PGTMRHPTPL QQEPRKISYS RIPESETETT
ASAPNSPRTP LTPPPASATS STTDACSVFD SDPSSPFHAR SASVSSINFT KNSDETHVPP
PVPPRRRPES APAESSPSKI TSVHLDSPPA IPPRQPTSKV YSPRYSVPDR TCISDPPESP
PVLPPREPVR TPDVFSSSPL HLQPPPLGRK SELGNTFFPN SPSPFTPPPP QIPSPHVARK
HLPSPPLIPQ DVDLHSVAGP PVPPRQSTSQ HIPKLPPKTY KREHTHPSMH RDGPPLLENA
HSS
//
