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Database: UniProt
Entry: A0A2I0LU61_COLLI
LinkDB: A0A2I0LU61_COLLI
Original site: A0A2I0LU61_COLLI 
ID   A0A2I0LU61_COLLI        Unreviewed;       635 AA.
AC   A0A2I0LU61;
DT   28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 1.
DT   05-DEC-2018, entry version 4.
DE   RecName: Full=Beta-galactosidase {ECO:0000256|RuleBase:RU000675};
DE            EC=3.2.1.23 {ECO:0000256|RuleBase:RU000675};
GN   Name=GLB1 {ECO:0000313|EMBL:PKK20958.1};
GN   ORFNames=A306_00012640 {ECO:0000313|EMBL:PKK20958.1};
OS   Columba livia (Rock dove).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Columbiformes; Columbidae; Columba.
OX   NCBI_TaxID=8932 {ECO:0000313|EMBL:PKK20958.1, ECO:0000313|Proteomes:UP000053872};
RN   [1] {ECO:0000313|EMBL:PKK20958.1, ECO:0000313|Proteomes:UP000053872}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   TISSUE=Blood {ECO:0000313|EMBL:PKK20958.1};
RX   PubMed=23371554; DOI=10.1126/science.1230422;
RA   Shapiro M.D., Kronenberg Z., Li C., Domyan E.T., Pan H., Campbell M.,
RA   Tan H., Huff C.D., Hu H., Vickrey A.I., Nielsen S.C., Stringham S.A.,
RA   Hu H., Willerslev E., Gilbert M.T., Yandell M., Zhang G., Wang J.;
RT   "Genomic diversity and evolution of the head crest in the rock
RT   pigeon.";
RL   Science 339:1063-1067(2013).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Hydrolysis of terminal non-reducing beta-D-galactose
CC         residues in beta-D-galactosides.; EC=3.2.1.23;
CC         Evidence={ECO:0000256|RuleBase:RU000675};
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 35 family.
CC       {ECO:0000256|RuleBase:RU003679, ECO:0000256|SAAS:SAAS00534244}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:PKK20958.1}.
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DR   EMBL; AKCR02000094; PKK20958.1; -; Genomic_DNA.
DR   RefSeq; XP_005500008.1; XM_005499951.1.
DR   Proteomes; UP000053872; Unassembled WGS sequence.
DR   GO; GO:0004565; F:beta-galactosidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   Gene3D; 2.60.120.260; -; 2.
DR   InterPro; IPR026283; B-gal_1-like.
DR   InterPro; IPR025300; BetaGal_jelly_roll_dom.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   InterPro; IPR031330; Gly_Hdrlase_35_cat.
DR   InterPro; IPR019801; Glyco_hydro_35_CS.
DR   InterPro; IPR001944; Glycoside_Hdrlase_35.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   PANTHER; PTHR23421; PTHR23421; 2.
DR   Pfam; PF13364; BetaGal_dom4_5; 1.
DR   Pfam; PF01301; Glyco_hydro_35; 1.
DR   PIRSF; PIRSF006336; B-gal; 2.
DR   PRINTS; PR00742; GLHYDRLASE35.
DR   SUPFAM; SSF49785; SSF49785; 1.
DR   SUPFAM; SSF51445; SSF51445; 1.
DR   PROSITE; PS01182; GLYCOSYL_HYDROL_F35; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000053872};
KW   Glycosidase {ECO:0000256|RuleBase:RU000675,
KW   ECO:0000256|SAAS:SAAS00108888};
KW   Hydrolase {ECO:0000256|RuleBase:RU000675,
KW   ECO:0000256|SAAS:SAAS00108869};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053872}.
FT   DOMAIN       51    366       Glyco_hydro_35. {ECO:0000259|Pfam:
FT                                PF01301}.
FT   DOMAIN      549    591       BetaGal_dom4_5. {ECO:0000259|Pfam:
FT                                PF13364}.
FT   ACT_SITE    198    198       Proton donor. {ECO:0000256|PIRSR:
FT                                PIRSR006336-1}.
FT   ACT_SITE    278    278       Nucleophile. {ECO:0000256|PIRSR:
FT                                PIRSR006336-1}.
SQ   SEQUENCE   635 AA;  71646 MW;  A3374CAF7C5C0D95 CRC64;
     MRTSNQLFSG VLRTKVILVK GMPKTHGRYK IGGVKDIPER SFGIDYDSGC FVKDGRPFRY
     ISGSIHYSRV PRYYWSDRLL KMKMAGLDAI QTYVPWNYHE TQMGVYDFSG DKDLEHFLQL
     ASDTGLLVIL RAGPYICAEW DMGGLPAWLL EKKSIVLRSS DSDYLAAVEK WMGVLLPKMR
     PHLYQNGGPV IMVQVENEYG SYFACDYDYL RFLLKLFRQH LGDEVVLFTT DGASQFHLRC
     GALQGLYATV DFAPGGNVTA AFLAQRGSEP RGPLVNSEFY TGWLDHWGHR HSVVPTETIA
     KTLNEILACG ANVNLYMFIG GTNFAYWNGA NMPYAPQPTS YDYDAPLSEA GDLTEKYFAL
     REVIGMYKQL PEGLIPPTTP KFAYGSVHLQ KYFGFVLYRT KLPKNCTEPT QLSSPLNGVH
     DRAYVSVDGI PQGVLERDKS LMINITGKAG ANLDILVENM GRVNFGRYNN DFKGLVSNLT
     LDQDTLVEWE IYPLDIDGAV NRGHLDQPKR FVGNPLSYEV PTFYTGRLSI PGGIPDLPQD
     TYVKFPDWTK GQIWINGFNL GRYWPARGPQ LTLFVPRNIL VSSVPNNITV LELEHSPCST
     SACEIEFVDK PIINATTQYE KYDSRLHLRD KLNHL
//
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