ID A0A2I0LW13_COLLI Unreviewed; 982 AA.
AC A0A2I0LW13;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE SubName: Full=RAS p21 protein activator (GTPase activating protein) 1 {ECO:0000313|EMBL:PKK21597.1};
GN Name=RASA1 {ECO:0000313|EMBL:PKK21597.1};
GN ORFNames=A306_00014215 {ECO:0000313|EMBL:PKK21597.1};
OS Columba livia (Rock dove).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Columbiformes; Columbidae; Columba.
OX NCBI_TaxID=8932 {ECO:0000313|EMBL:PKK21597.1, ECO:0000313|Proteomes:UP000053872};
RN [1] {ECO:0000313|EMBL:PKK21597.1, ECO:0000313|Proteomes:UP000053872}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Blood {ECO:0000313|EMBL:PKK21597.1};
RX PubMed=23371554; DOI=10.1126/science.1230422;
RA Shapiro M.D., Kronenberg Z., Li C., Domyan E.T., Pan H., Campbell M.,
RA Tan H., Huff C.D., Hu H., Vickrey A.I., Nielsen S.C., Stringham S.A.,
RA Hu H., Willerslev E., Gilbert M.T., Yandell M., Zhang G., Wang J.;
RT "Genomic diversity and evolution of the head crest in the rock pigeon.";
RL Science 339:1063-1067(2013).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PKK21597.1}.
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DR EMBL; AKCR02000078; PKK21597.1; -; Genomic_DNA.
DR RefSeq; XP_005515984.1; XM_005515927.1.
DR AlphaFoldDB; A0A2I0LW13; -.
DR STRING; 8932.A0A2I0LW13; -.
DR InParanoid; A0A2I0LW13; -.
DR Proteomes; UP000053872; Unassembled WGS sequence.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0050896; P:response to stimulus; IEA:UniProt.
DR CDD; cd08400; C2_Ras_p21A1; 1.
DR CDD; cd13260; PH_RASA1; 1.
DR CDD; cd05391; RasGAP_p120GAP; 1.
DR CDD; cd10354; SH2_Cterm_RasGAP; 1.
DR CDD; cd11788; SH3_RasGAP; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 3.30.505.10; SH2 domain; 2.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR039360; Ras_GTPase.
DR InterPro; IPR035842; RasGAP_C_SH2.
DR InterPro; IPR023152; RasGAP_CS.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR035652; RasGAP_SH3.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR10194:SF146; RAS GTPASE-ACTIVATING PROTEIN 1; 1.
DR PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00616; RasGAP; 1.
DR Pfam; PF00017; SH2; 2.
DR Pfam; PF00018; SH3_1; 1.
DR PRINTS; PR00401; SH2DOMAIN.
DR SMART; SM00239; C2; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00323; RasGAP; 1.
DR SMART; SM00252; SH2; 2.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF55550; SH2 domain; 2.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
DR PROSITE; PS50001; SH2; 2.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000053872};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 117..207
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 214..276
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 286..376
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 409..512
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 512..625
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 683..877
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
SQ SEQUENCE 982 AA; 112497 MW; 976F3BE2EAE8EF5D CRC64;
MCVRVPSKSR RSFALSSPLP FASPRSSLAG RLLRRVRRSR CGQTRVPALG PRWGRAGTGF
DPLHLEEESF LDLQGVSYFV NVGLSLVRVV VTFTGNEQTC VPDVLCMLTS GIFNPGWYHG
KLDRTIAEER LRQAGKPGSY LIRESDRRPG SFVLSFLSKT NVNHFRIIAM CGDYYIGGRR
FASLSDLIGY YSHVSCLLKG EKLLFPVAPP EPVEDRRRVR AILPYTKVPE TDEISFLKGD
MFIVHNELED GWMWVTNLRT DEQGLIVEDL VEEVGREEDP HEGKIWFHGK ISKQEAYNLL
MTVGQVCSFL VRPSDNTPGD YSLYFRTSEN IQRFKICPTS NNQFMMGGRY YNSIADIIEH
YRKEQIVEGY YLKDPVPMQH QEQVLNDTLD GKEIYNTIRR KTKDAFYKNI VKKGYLLKKS
KGKRWKNLYF ILEGNDAQLI YFESEKRATK PKGLIDLSVC SVYGVHDSLF GRPNCFQIVV
QHFSEEHYIF YFAGETPEQA QDWMKALQMF CSLRKTSPGT SNKRLRQVSS LILHVEEAHT
LPVKHFTNPY CNIYLNSVQV AKTHIREGQN PVWSEEFVFD DLSSDINRFE ISLSNKTKKS
KDPDILFMRC QLSRLQKGHA TDEWFQLSSH VPLKGIEPGS LRVRARYSME KIMPEEEYSE
FKELILQKEL HVVYALSHVC GQDRTLLAGI LLKIFLHEKL ESLLLRTLND REISMEDEAT
TLFRATTLAS TLMEQYMKAT ATSFVHHALK DSILKIMESK QSCELNPSKL EKNEDVNTNL
AHLLSILSEL VEKIFMAAEI LPPTLRYIYG CLQKSVQNKW PANTTMRTRV VSGFVFLRLI
CPAILNPRMF NIISDSPSPT AARTLTLVAK SVQNLANLVE FGAKEPYMEG VNPFIKSNKH
RMIMFLDELG NVPELPDTTE HSRTDLSRDL AALHEICVAH SDELRTLSNE RGVMQHVLKK
LLAITELLQQ KQNQYSVSNN TR
//