ID A0A2I0LWK6_COLLI Unreviewed; 4396 AA.
AC A0A2I0LWK6;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=FAT atypical cadherin 2 {ECO:0000313|EMBL:PKK21808.1};
GN Name=FAT2 {ECO:0000313|EMBL:PKK21808.1};
GN ORFNames=A306_00010647 {ECO:0000313|EMBL:PKK21808.1};
OS Columba livia (Rock dove).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Columbiformes; Columbidae; Columba.
OX NCBI_TaxID=8932 {ECO:0000313|EMBL:PKK21808.1, ECO:0000313|Proteomes:UP000053872};
RN [1] {ECO:0000313|EMBL:PKK21808.1, ECO:0000313|Proteomes:UP000053872}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Blood {ECO:0000313|EMBL:PKK21808.1};
RX PubMed=23371554; DOI=10.1126/science.1230422;
RA Shapiro M.D., Kronenberg Z., Li C., Domyan E.T., Pan H., Campbell M.,
RA Tan H., Huff C.D., Hu H., Vickrey A.I., Nielsen S.C., Stringham S.A.,
RA Hu H., Willerslev E., Gilbert M.T., Yandell M., Zhang G., Wang J.;
RT "Genomic diversity and evolution of the head crest in the rock pigeon.";
RL Science 339:1063-1067(2013).
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PKK21808.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AKCR02000071; PKK21808.1; -; Genomic_DNA.
DR RefSeq; XP_005503435.1; XM_005503378.1.
DR STRING; 8932.A0A2I0LWK6; -.
DR GeneID; 102093070; -.
DR KEGG; clv:102093070; -.
DR CTD; 2196; -.
DR InParanoid; A0A2I0LWK6; -.
DR OrthoDB; 2961370at2759; -.
DR Proteomes; UP000053872; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 32.
DR CDD; cd00054; EGF_CA; 3.
DR CDD; cd00110; LamG; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 2.60.40.60; Cadherins; 33.
DR Gene3D; 2.10.25.10; Laminin; 3.
DR InterPro; IPR039808; Cadherin.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR001791; Laminin_G.
DR PANTHER; PTHR24027; CADHERIN-23; 1.
DR PANTHER; PTHR24027:SF422; NEURAL-CADHERIN 2-RELATED; 1.
DR Pfam; PF00028; Cadherin; 29.
DR Pfam; PF00008; EGF; 2.
DR Pfam; PF02210; Laminin_G_2; 1.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 33.
DR SMART; SM00181; EGF; 3.
DR SMART; SM00179; EGF_CA; 3.
DR SMART; SM00282; LamG; 1.
DR SUPFAM; SSF49313; Cadherin-like; 33.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 3.
DR PROSITE; PS00232; CADHERIN_1; 11.
DR PROSITE; PS50268; CADHERIN_2; 32.
DR PROSITE; PS00022; EGF_1; 3.
DR PROSITE; PS50026; EGF_3; 3.
DR PROSITE; PS50025; LAM_G_DOMAIN; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043}; Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000053872};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..4396
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014113908"
FT TRANSMEM 4082..4102
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 37..151
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 152..259
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 366..461
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 462..567
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 568..716
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 718..822
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 823..931
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 928..1034
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1043..1144
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1140..1245
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1246..1357
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1353..1450
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1451..1556
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1557..1661
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1662..1759
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1768..1873
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1970..2071
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2072..2172
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2173..2273
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2274..2380
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2381..2482
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2483..2586
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2587..2693
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2694..2799
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2800..2907
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2908..3012
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3013..3114
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3115..3219
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3220..3324
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3325..3429
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3430..3534
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3535..3622
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3775..3947
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 3949..3986
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 3988..4024
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 4026..4062
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 4245..4270
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4250..4269
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 3976..3985
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 4014..4023
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 4052..4061
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 4396 AA; 484841 MW; 8ECB875DEF3FDE31 CRC64;
MEVTIRRHFL SVAVFLMSCV VHKASCEKGN TSPLHFTHFF YNATIYENSA PKTYVESYVK
MGIYKTDPEW DIRYRIASGD NTGLFKTEEH VIGDFCFLRI RTRSSNTALL NREVKDSYML
IIKATESTFA YEAWAKVLIH ILDRNDLKPL FSPPSYKVSI REDTPLKTVV CTLSATDADA
GQNAEFYYAL NTKSDLFTVH PTTGAVMTTG RLNSTHRGRH HLQVLAVDRM RKITEGNGFG
NLANLMIQVE PSARKPPSIS SVKVTPPDSD EDFLYATLSV ESGDSEAGID SVDFVDGDPG
RHFKAIKSYF GSTEFMIVST KEINWLLYPF GFNLSLQAKD KSKPPLFSPI RVIHIPPSRY
VSARFEKEVY HVQLSEFSPA GSQVVMVKIT PVFPNLKYIL RPTPDSTSFK INPHTGLITT
ARTMDFREQS HFVLEVTTTN SHTSTTVHID ITDCNNHAPS FSQSSYRGAF DENVPPGTSV
LTVQATDEDE GNNGFVTYTI ANQKSVPFVI DPYSGIISTS KSMDYELMQR WYHLRVWASD
WGSPFRHETE VYVSLMLSNV NDNAPVFEKA SCSGTIPRDF PVGNPVATVS AIDSDELQHI
KYEIKSGNEL RHFELNPVSG VISLRISLRD IPSEQPLFYS LKITATDGEN YALPTSVNIS
VVGQGLPVKM QCEETGVLKQ LTETIIHSIE SQSQGHGQDD ETSLNLHLIN HNAPKFDDSF
PRSIDIIETV PINSTIADLS AVDPDTGFNG KLVYVISDGN DDSCFTIDLE LGLLQVLSPL
DHERTSFYIL NITVYDLGTP QKSSWKLLAV NVLDTNDNTP KFPQGAYWVA IPEHVATGTT
IAQLKAEDAD TDDNGRVKYS LLSPTDKFAI NSVTGEVTVT GALDRELWPY YVLKIEARDQ
PKTGYELFSV TDLTVTLEDV NDNTPQCLPA LNNVKVPEDL PVGTILLFLE VFDPDTGSGG
EVRYSLISDE EMMFHMDKLT GALRLEKELD YEKKDSYNLT VQVSDGGKPF SRSSLCHLEV
NILDVNENLH PPRFASFVFK GWVQENSPEG TSVMMVTAKD IDKGKDGEVQ YFFREGTGLS
VFSIEKDTGT IRTTGPLDRE GTSHYWLTVL ALDLGTIPLS SVTEIYIEVT DTNDNPPQMS
RPVFYTSVME NSPPNTSVLQ LDALDPDSSS EGKLTFHILT GNPQGLFTIN LITGLISTTS
RQLDREYKAE HILEVAVSDN GEPALKSTSR VVIQVLDAND SPPTFPHKLF MVQLPERDAS
ETPLPVYRLI ASDRDQGQNS HITYTIEEED EGIFTINPTT GMVFSRKAFP ASEYNILTVK
ATDGGSPPLS SHVRLHISWV TRPSPSSEPL AFDEPHFNFA VMETDPVNHM VGVISIEMGP
SQVWFNITGG DDDMDFDIEK STGSMVIARP LDARKKSSYN LTVEVTDGST TIKTQAFIHV
IDINQHRPQF LESHYEERIP EDTPSGREIL RVSATDKDKG KGLIYTIHGS VDPKSTRLFQ
LDPSSGVLTT AEGFSSQPMP QHTLTVMVRD QEVPIKRNFV RVIIHVDNCN LHPPQFSSIH
YEAEVLDSAV VGTEIMQVRA LDQDQGANAE IHYSLQAGNG EGFFSIDLYS GIITVAQKLD
PSRQERFTLI VKAEDQGFPQ LKDSATVHVR IRPSDRTPPK FPEAEYITEI SESIAVGSPL
IQVSATSLSP VSYEIKDGNG DGVFSMNYQS GLISTQKSLD FEQVSFYQLK VRGTNMAGAF
TDTIVLIYVI DENDNAPIFV KPSFVGWIME NAPSQSMVLD ESNAPLVTHA TDADQDSNAL
LVYEILETEA LKYFTVDPST GTLTSRADID YELTPVFHFS VHAHDSGNPS LFASKPAKVT
IHVKDVNDSP PVFSKDNYEL SVLLPAHPGM ELLSVQAKDA DSEVTYSIVK GNLDNAFYIH
PVTGLLSILN ATGLGSHREL TVRAGDGLYK STALVKLNLT QAQGKGLKFD QDVYTATVME
NSTDEKTLTV LGVKGYQLNE PLFYSLLNGK ERFKMIQASG VLQTKGVKFD REAQDMHEVA
VEVKDNRKPP RVSQATVKVY VEDVNDNPPQ FENVPYYTSV QDGTEPGDVL FQVSATDKDI
GDNGAITYSF AEDYKYFWID PYLGDISLKK PLDYQALNKY NLRVIAKDKG EPPLHAEEEV
VISVRNKSNP LFQSLYYRVK VPENIPLYTS ILHIQARSPE GLRLIYNIVE EDSLKLFSTD
FKTGVLTVTG QLDYELETKH TFTVKATDTA LGSFSEARVE VEVEDVNDNP PVFSQMIYTA
SVSESLPAQT PVVQLFASDK DSGRNKAVSY QILDDGSDAT KFFNIDGSTG QITTAQALDY
ERNQQFRMKV RATDHGMPPL SSDALVIVDV TDINDNPPEF SQLQYEAKVS EMATCGHIVI
KVQALDPDSG DTTRLEYVIL SGNDNRHFTI NSTSGIISMF NRCKKDLESF YNLRVSASDG
VFKSTVPVYI NTTNANKYSP SFRQNVYEAE LAENAEIGTK VIELLAIDPD GGPYGTIDYT
IINKLAHEKF SIDDKGHITT LQKLDRENST ERVIAIKVMA KDGGGKVAFC TVKIILTDEN
DNPPQFKASE YTLSIQSNVS KGSPVIQVLA YDADEGANAD VIYSVDSVED VAEDLVEINA
ATGVVKVKES LVGLENRAFN FKVKAEDSRP PHWNSLVPVN LQIVPREVTL PRFSEPLYTF
SASEDLPEGS EIGSVRAFAE EPIIYSLVKG TTAESNKDEV FTLDKQTGAL KIKKAMDHET
TKWYQIDVMA HCSHQETELV SLVSVNIHVQ DVNDNRPVFE ADPYKAFVME NMPSGTTVIQ
VTANDQDTGN DGQVTYSLEA ESGNLRGLFT IDGESGWITT LKELDCEAQE IYRFYVVATD
HGRKVQLSSQ TLVEVTVSDE NDNAPQFTSD FYKGSVIENA EPGQVVVTLS TIDADISEQN
RRVTCYITEG DALGQFTVNQ IEGEWTISSK KPLDREDTEK YLLKVMASDG KFQAITEVEI
FVLDINDNSP ECGQIFYTGR VSEGALPGLF ILKISATDPD VGSNAQITYS LHGPGAEEFR
LGPHTGELTT SAPLDREQKP MYHLVAKATD GGGRSCQADI TLIVEDTNDN APRFFPSHCA
VAVFDNTTTK TPIAVVAARD LDEGPNAEVV YSLSDSANGH FSIEETTGVI RLEKPLKDSQ
HSAFELTVRA TDRGTPEPLS ALGTVTVSVV DLNEYLPVFL APEYMAMVKE DVAVGTEVLN
LSALTRDNAE NTEIKYEIVN GNDHGKFQLN SNTGALYING SLDFEASHEY YLSIEGTRKG
SASLSDVTMV VINITDINDH APEFIQDPYF ADIREDAAVG EIILTVSADD LDGAMNNQIT
YSIVEGNPLG HFAIQPKSGQ ISIAKHLDRE EIPSYSLTVR ATDNGHPAQF SDVALHIHVS
DVNDNPPRFF QLNYSVVVQE NAPVGTSVLE LIMSDRDTPE NGPPYSFQIT QGNDGKAFDV
TQNGLLVTSS ILNRRMKEQY LLQVQVSDSG IPPLSSSAFI NIQVTEQSQY APSALPLEIF
ITTNEEAFRG GVLGKIHATD RDPHDTLVYT LVAEVPQEGL FSVGTADGKI IAGDKLPHGH
YLLNVTVSDG TFTATTSVNV HVWCFTQEAL DKAVVLHFRH LSPEEFVGDH WRNLQRFLGN
ILVTRRQNIH MASLQPAATS DGVDLLLAVG EPHGSLYEPR ILANKITVSA GEMDQLVGLR
MKKAIHVPCH GPDCAHRVCK ETIQLDPGMM STYSTARLSV LTPRHSLEQI CSCNGTAVRF
GGHSYIWYQH SQVSSWHMHF RLKTRQLHAV VFHSNGTDHT ILEMINGVPQ LGYSCQGNYT
GNLSSSRFVS DGEWHSVFLE VKNTSVRLLI DGLGNTSLQL PLTCSISWGR RDLLFGGLRQ
PLQSQRVTRG FRGCLDVVAI NGREVVLLPG KGQSKEIVEE MGIKQCCSPT GACSSNPCLN
NGMCSETHGG GYTCICPGLF SGEHCELGDS PCESKPCLHG GTCTLSATGY SCHCPDWYLG
ERCEKLAEEC QDNPCRNAGR CVSNQGSIHC ICPSDYQGAY CTQPIITPAI VPTQWAVGPE
EIAEIAAGVL GVAILAAAFV VIRKRYRHRA KAHKPVARED PDLLSKSEFS KSVGVGTQAV
PPIELNILSD TAHNNLDRAT PEQRKPTSTP EFVTFNSANA PKHRGTIVCS VAPNLPPAAP
PSNSDNESFI KCTWAREEMV YPAETTYWPP RYLSSDVQEY SHYEIIQGPP PSSSHPPLPP
PPPPPADTEP VALYGGFPFP LDQSNKRAPI PPRYSNQNLE DFLPLGPVDM GASQCQNEYT
AISYYPAQLV QGEGAPYQPD PGYKRVSMRL SVAQPSYADC EVGHQPSIRA QPLPPPNYEG
SDMVESDYGS CEEVMF
//
