ID A0A2I0LWN8_COLLI Unreviewed; 694 AA.
AC A0A2I0LWN8;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE RecName: Full=Zona pellucida sperm-binding protein 2 {ECO:0000256|ARBA:ARBA00040237};
DE AltName: Full=Zona pellucida glycoprotein 2 {ECO:0000256|ARBA:ARBA00042572};
DE AltName: Full=Zona pellucida protein A {ECO:0000256|ARBA:ARBA00042272};
DE Flags: Fragment;
GN Name=ZP2 {ECO:0000313|EMBL:PKK21856.1};
GN ORFNames=A306_00008424 {ECO:0000313|EMBL:PKK21856.1};
OS Columba livia (Rock dove).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Columbiformes; Columbidae; Columba.
OX NCBI_TaxID=8932 {ECO:0000313|EMBL:PKK21856.1, ECO:0000313|Proteomes:UP000053872};
RN [1] {ECO:0000313|EMBL:PKK21856.1, ECO:0000313|Proteomes:UP000053872}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Blood {ECO:0000313|EMBL:PKK21856.1};
RX PubMed=23371554; DOI=10.1126/science.1230422;
RA Shapiro M.D., Kronenberg Z., Li C., Domyan E.T., Pan H., Campbell M.,
RA Tan H., Huff C.D., Hu H., Vickrey A.I., Nielsen S.C., Stringham S.A.,
RA Hu H., Willerslev E., Gilbert M.T., Yandell M., Zhang G., Wang J.;
RT "Genomic diversity and evolution of the head crest in the rock pigeon.";
RL Science 339:1063-1067(2013).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}. Zona pellucida
CC {ECO:0000256|ARBA:ARBA00024183}.
CC -!- SIMILARITY: Belongs to the ZP domain family. ZPA subfamily.
CC {ECO:0000256|ARBA:ARBA00038403}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PKK21856.1}.
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DR EMBL; AKCR02000070; PKK21856.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2I0LWN8; -.
DR STRING; 8932.A0A2I0LWN8; -.
DR InParanoid; A0A2I0LWN8; -.
DR Proteomes; UP000053872; Unassembled WGS sequence.
DR GO; GO:0035805; C:egg coat; IEA:UniProtKB-SubCell.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0007338; P:single fertilization; IEA:UniProtKB-KW.
DR Gene3D; 2.60.40.4100; Zona pellucida, ZP-C domain; 1.
DR Gene3D; 2.60.40.3210; Zona pellucida, ZP-N domain; 1.
DR InterPro; IPR042235; ZP-C.
DR InterPro; IPR048290; ZP_chr.
DR InterPro; IPR001507; ZP_dom.
DR InterPro; IPR017977; ZP_dom_CS.
DR PANTHER; PTHR23343; ZONA PELLUCIDA SPERM-BINDING PROTEIN; 1.
DR PANTHER; PTHR23343:SF4; ZONA PELLUCIDA SPERM-BINDING PROTEIN 2; 1.
DR Pfam; PF00100; Zona_pellucida; 1.
DR PRINTS; PR00023; ZPELLUCIDA.
DR SMART; SM00241; ZP; 1.
DR PROSITE; PS00682; ZP_1; 1.
DR PROSITE; PS51034; ZP_2; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Fertilization {ECO:0000256|ARBA:ARBA00023279};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:PKK21856.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000053872};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..694
FT /note="Zona pellucida sperm-binding protein 2"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014180671"
FT TRANSMEM 655..680
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 346..612
FT /note="ZP"
FT /evidence="ECO:0000259|PROSITE:PS51034"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:PKK21856.1"
SQ SEQUENCE 694 AA; 77730 MW; 4A26E369EC92C168 CRC64;
LLLLFGFLLP LTPCADGWED QYLLESVTCH RDRMEVEFSR ELGNYSWLVY VVDMSGEEMV
SCDHTVDYER LLLSVLFVNC TSLEDDQHWL RLRLMVNDTM GEEKNVTYSA HCNTVNADEI
ITPFFAGVTN CTKDFMAVTF PRLIPDSGDE HMVPATPLAW TLLIYDGTRI QQLSLGQAMQ
QGYNFLADGH NLIFQVSFTA TGVVTYKHND KVLYTVAFKL MYGPPENRLT VESRMLCAPG
PAICNATHMT VAIPAFPGTL MAVGVENKTI PVDQLQENGI ALDTKRGVKL HISRRGLKSR
LHGESCSGLQ SYMPSLKLDF HFNGKTTAMV MHPECPCDKH APIAAVCTQD GYMDFEVLAD
STTPPLDLDT LRLRDSACRP AFKSPLNDRV WFHVPLKGCG TRYWFDGERI VYENEVRALW
ADLPLRIISR DSEFRLTVLC SFSNGDASLT IRVDNLPALA SSVNQGPLSL VLLSYPEVSY
RQPYRDDQYP IVRYLRQPIF LEVQVLNRND PNLHLVLDDC WATTSRDSSS IPQWNIVVDG
CEYDLDSYMT VFHPVGHGVS YANYRQRLEV KTFAFVSGDK ALPGLVYFHC SVLICDRFQP
DSHLCMARCP RPSRGKRESG MPDASSAVVS LQGPVLLVPE GWSASQGSNL LSKEVWAGVT
MTAVGILSLV AAMLLLLALL KWLKRRASMV NVTC
//
