ID A0A2I0LWS7_COLLI Unreviewed; 429 AA.
AC A0A2I0LWS7;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 24-JAN-2024, entry version 17.
DE RecName: Full=Voltage-dependent calcium channel gamma-3 subunit {ECO:0000256|ARBA:ARBA00039975};
DE AltName: Full=Neuronal voltage-gated calcium channel gamma-3 subunit {ECO:0000256|ARBA:ARBA00042269};
DE AltName: Full=Transmembrane AMPAR regulatory protein gamma-3 {ECO:0000256|ARBA:ARBA00042597};
GN Name=CACNG3 {ECO:0000313|EMBL:PKK21884.1};
GN ORFNames=A306_00008467 {ECO:0000313|EMBL:PKK21884.1};
OS Columba livia (Rock dove).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Columbiformes; Columbidae; Columba.
OX NCBI_TaxID=8932 {ECO:0000313|EMBL:PKK21884.1, ECO:0000313|Proteomes:UP000053872};
RN [1] {ECO:0000313|EMBL:PKK21884.1, ECO:0000313|Proteomes:UP000053872}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Blood {ECO:0000313|EMBL:PKK21884.1};
RX PubMed=23371554; DOI=10.1126/science.1230422;
RA Shapiro M.D., Kronenberg Z., Li C., Domyan E.T., Pan H., Campbell M.,
RA Tan H., Huff C.D., Hu H., Vickrey A.I., Nielsen S.C., Stringham S.A.,
RA Hu H., Willerslev E., Gilbert M.T., Yandell M., Zhang G., Wang J.;
RT "Genomic diversity and evolution of the head crest in the rock pigeon.";
RL Science 339:1063-1067(2013).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU363085}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU363085}.
CC -!- SIMILARITY: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
CC {ECO:0000256|ARBA:ARBA00007111, ECO:0000256|RuleBase:RU363085}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU363085}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PKK21884.1}.
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DR EMBL; AKCR02000070; PKK21884.1; -; Genomic_DNA.
DR RefSeq; XP_013223506.1; XM_013368052.1.
DR AlphaFoldDB; A0A2I0LWS7; -.
DR STRING; 8932.A0A2I0LWS7; -.
DR InParanoid; A0A2I0LWS7; -.
DR Proteomes; UP000053872; Unassembled WGS sequence.
DR GO; GO:0034702; C:monoatomic ion channel complex; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0005262; F:calcium channel activity; IEA:UniProtKB-KW.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 1.20.140.150; -; 1.
DR InterPro; IPR000961; AGC-kinase_C.
DR InterPro; IPR017892; Pkinase_C.
DR InterPro; IPR004031; PMP22/EMP/MP20/Claudin.
DR InterPro; IPR008368; VDCC_gsu.
DR PANTHER; PTHR12107; VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA SUBUNIT; 1.
DR PANTHER; PTHR12107:SF5; VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA-3 SUBUNIT; 1.
DR Pfam; PF00433; Pkinase_C; 1.
DR Pfam; PF00822; PMP22_Claudin; 1.
DR PRINTS; PR01792; VDCCGAMMA.
DR SMART; SM00133; S_TK_X; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Calcium {ECO:0000256|RuleBase:RU363085};
KW Calcium channel {ECO:0000256|RuleBase:RU363085};
KW Calcium transport {ECO:0000256|RuleBase:RU363085};
KW Ion channel {ECO:0000256|RuleBase:RU363085};
KW Ion transport {ECO:0000256|RuleBase:RU363085};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Membrane {ECO:0000256|RuleBase:RU363085};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000053872};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|RuleBase:RU363085};
KW Transmembrane helix {ECO:0000256|RuleBase:RU363085};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU363085};
KW Voltage-gated channel {ECO:0000256|RuleBase:RU363085}.
FT TRANSMEM 220..242
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363085"
FT TRANSMEM 249..273
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363085"
FT TRANSMEM 293..315
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363085"
FT DOMAIN 96..143
FT /note="AGC-kinase C-terminal"
FT /evidence="ECO:0000259|SMART:SM00133"
SQ SEQUENCE 429 AA; 47175 MW; 01DB72B586CA0D5D CRC64;
MFLGGRTLGM PLLRRAEHCC LGISGTALNR EDCGMRLGAL ALQGKLLGGS AAEAVPRRRL
LRRGGLRVAT GSCCGCDVLL ARQDEDGEDL GHTLAVHLLE KDKRDTSNFD KEFTRQPVEL
TPTDKLFIMN LDQNEFAGFS YTNPEFVINV APGVSGFPQP GSSASGGGKQ AVVAKLLPPH
WKVLGTFRGV CKKIDHFPED ADYEQDTAEY LLRAVRASSI FPILSVGLLF FGGLCVAASE
FYKSKHNVIL SAGIFFVSAG LSNIIGIIVY ISANAGDPGQ SDSKKSYSYG WSFYFGALSF
IIAEMVGVIA VHMYIEKHRQ IRAKSHSELL KKSAFTRLPP YRYRFRRRSS SRSTEPRSRD
MSPVSKAFSA IPSTDISMFT LSRDPSKVTM GTLLNSERDH GFLQVHNSIP KEFKESLHNN
PANRRTTPV
//
