ID A0A2I0LY10_COLLI Unreviewed; 464 AA.
AC A0A2I0LY10;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 24-JAN-2024, entry version 16.
DE RecName: Full=Tubby-like protein {ECO:0000256|RuleBase:RU361125};
GN Name=TULP3 {ECO:0000313|EMBL:PKK22319.1};
GN ORFNames=A306_00010032 {ECO:0000313|EMBL:PKK22319.1};
OS Columba livia (Rock dove).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Columbiformes; Columbidae; Columba.
OX NCBI_TaxID=8932 {ECO:0000313|EMBL:PKK22319.1, ECO:0000313|Proteomes:UP000053872};
RN [1] {ECO:0000313|EMBL:PKK22319.1, ECO:0000313|Proteomes:UP000053872}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Blood {ECO:0000313|EMBL:PKK22319.1};
RX PubMed=23371554; DOI=10.1126/science.1230422;
RA Shapiro M.D., Kronenberg Z., Li C., Domyan E.T., Pan H., Campbell M.,
RA Tan H., Huff C.D., Hu H., Vickrey A.I., Nielsen S.C., Stringham S.A.,
RA Hu H., Willerslev E., Gilbert M.T., Yandell M., Zhang G., Wang J.;
RT "Genomic diversity and evolution of the head crest in the rock pigeon.";
RL Science 339:1063-1067(2013).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the TUB family. {ECO:0000256|ARBA:ARBA00007129,
CC ECO:0000256|RuleBase:RU361125}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PKK22319.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AKCR02000064; PKK22319.1; -; Genomic_DNA.
DR RefSeq; XP_005509835.2; XM_005509778.2.
DR AlphaFoldDB; A0A2I0LY10; -.
DR STRING; 8932.A0A2I0LY10; -.
DR GeneID; 102085458; -.
DR KEGG; clv:102085458; -.
DR CTD; 7289; -.
DR InParanoid; A0A2I0LY10; -.
DR OrthoDB; 603296at2759; -.
DR Proteomes; UP000053872; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR InterPro; IPR025659; Tubby-like_C.
DR InterPro; IPR000007; Tubby_C.
DR InterPro; IPR018066; Tubby_C_CS.
DR InterPro; IPR005398; Tubby_N.
DR PANTHER; PTHR16517; TUBBY-RELATED; 1.
DR PANTHER; PTHR16517:SF138; TUBBY-RELATED PROTEIN 3; 1.
DR Pfam; PF01167; Tub; 1.
DR Pfam; PF16322; Tub_N; 2.
DR PRINTS; PR01573; SUPERTUBBY.
DR PRINTS; PR01574; TUBBYPROTEIN.
DR SUPFAM; SSF54518; Tubby C-terminal domain-like; 1.
DR PROSITE; PS01200; TUB_1; 1.
DR PROSITE; PS01201; TUB_2; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000053872};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 30..85
FT /note="Tubby N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16322"
FT DOMAIN 85..196
FT /note="Tubby N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16322"
FT DOMAIN 217..459
FT /note="Tubby C-terminal"
FT /evidence="ECO:0000259|Pfam:PF01167"
FT REGION 37..83
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 111..199
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 173..199
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 464 AA; 52168 MW; 1BF05194E8CB33B2 CRC64;
MEGARGRSGP IDDRIFEDES MKLRQLKLEN QRALLEKKQR KKRLDPLMVQ PNPEAKLCRS
KPKGHEEQTP LVESPTPFHS EVTLHGIDGP AAFLKSEVQD LDTKLQNLCA GSSKTEDNAD
QEDYGEALTD TSGKPDLQEI LQKRGISGSL NFDEEDTEEE EAAKRPASHS PCPESERPSS
ATSEKSFAET GASCSPSTQT DVQLGEVENL ENFALCPAPR GITVKCRITR DKKGMDRGLF
PTYYMHLERD DNRKTFLLAG RKRKKSKTSN YLISVDPTDL SREGESFIGK LRSNLMGTKF
TVYDHGVSPV KAQGLVEKAY MRQELAAICY ETNVLGFKGP RKMSVIIPGM NMNHKRIPIH
PRNEHESLLS KWQSKNLENL IELHNKAPVW NDDTQSYVLN FHGRVTQASV KNFQIVHDND
PDYIVMQFGR VAEDVFTLDY NYPLCALQAF AIGLSSFDSK LACE
//
