ID A0A2I0LY30_COLLI Unreviewed; 428 AA.
AC A0A2I0LY30;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Growth differentiation factor 2 {ECO:0000313|EMBL:PKK22341.1};
GN Name=GDF2 {ECO:0000313|EMBL:PKK22341.1};
GN ORFNames=A306_00010362 {ECO:0000313|EMBL:PKK22341.1};
OS Columba livia (Rock dove).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Columbiformes; Columbidae; Columba.
OX NCBI_TaxID=8932 {ECO:0000313|EMBL:PKK22341.1, ECO:0000313|Proteomes:UP000053872};
RN [1] {ECO:0000313|EMBL:PKK22341.1, ECO:0000313|Proteomes:UP000053872}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Blood {ECO:0000313|EMBL:PKK22341.1};
RX PubMed=23371554; DOI=10.1126/science.1230422;
RA Shapiro M.D., Kronenberg Z., Li C., Domyan E.T., Pan H., Campbell M.,
RA Tan H., Huff C.D., Hu H., Vickrey A.I., Nielsen S.C., Stringham S.A.,
RA Hu H., Willerslev E., Gilbert M.T., Yandell M., Zhang G., Wang J.;
RT "Genomic diversity and evolution of the head crest in the rock pigeon.";
RL Science 339:1063-1067(2013).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PKK22341.1}.
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DR EMBL; AKCR02000063; PKK22341.1; -; Genomic_DNA.
DR RefSeq; XP_005498047.1; XM_005497990.1.
DR AlphaFoldDB; A0A2I0LY30; -.
DR STRING; 8932.A0A2I0LY30; -.
DR GeneID; 102087801; -.
DR KEGG; clv:102087801; -.
DR CTD; 2658; -.
DR InParanoid; A0A2I0LY30; -.
DR OrthoDB; 2912454at2759; -.
DR Proteomes; UP000053872; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR CDD; cd19400; TGF_beta_BMP9; 1.
DR Gene3D; 2.60.120.970; -; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR001111; TGF-b_propeptide.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848:SF157; GROWTH_DIFFERENTIATION FACTOR 2; 1.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR Pfam; PF00688; TGFb_propeptide; 1.
DR PRINTS; PR00669; INHIBINA.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354};
KW Reference proteome {ECO:0000313|Proteomes:UP000053872};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..428
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014137616"
FT DOMAIN 316..428
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
FT REGION 288..321
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 288..311
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 428 AA; 48504 MW; 2F003CB874E1F32F CRC64;
MHYFGVLAAL SVFNIIACLT RGKPLEDWDK LSAMGKSDAR FHDPGEVEDE THFDFKSLLE
NMKTDLLRSL NMSRVPSQVK TKEEPPQFMI DLYNRYAADK SSIPSSNIVR SFSTEDVVSL
ASPEENPFQK HILLFNISIP RYEEITRAEL RIYISCHREA GSLSRLEGNM VIYDILDSDH
WKNPESTKSF LVSHNIQECG WEMFEVSRAV KRWVRADKLK TKNKLEVVIK SKALGGFTCG
KLDISVTPDT KNLPLLIVFS NDRSNGTKET KVELRDMIVH EQESVLKKLG KNNTSSEEEE
QGEEKAIPGP HQHSSRSKRS ISANHCRRTS LHVNFEEIGW DSWIIAPKDY EAFECKGGCF
FPLTDNVTPT KHAIVQTLVH LQNPKKASKA CCVPTKLDSI SILYKDDAGV PTLIYNYEGM
KVAECGCR
//
