ID A0A2I0LYD9_COLLI Unreviewed; 1353 AA.
AC A0A2I0LYD9;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 15.
DE SubName: Full=Latent transforming growth factor beta binding protein 1, transcript variant X2 {ECO:0000313|EMBL:PKK22436.1};
GN Name=LTBP1 {ECO:0000313|EMBL:PKK22436.1};
GN ORFNames=A306_00010435 {ECO:0000313|EMBL:PKK22436.1};
OS Columba livia (Rock dove).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Columbiformes; Columbidae; Columba.
OX NCBI_TaxID=8932 {ECO:0000313|EMBL:PKK22436.1, ECO:0000313|Proteomes:UP000053872};
RN [1] {ECO:0000313|EMBL:PKK22436.1, ECO:0000313|Proteomes:UP000053872}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Blood {ECO:0000313|EMBL:PKK22436.1};
RX PubMed=23371554; DOI=10.1126/science.1230422;
RA Shapiro M.D., Kronenberg Z., Li C., Domyan E.T., Pan H., Campbell M.,
RA Tan H., Huff C.D., Hu H., Vickrey A.I., Nielsen S.C., Stringham S.A.,
RA Hu H., Willerslev E., Gilbert M.T., Yandell M., Zhang G., Wang J.;
RT "Genomic diversity and evolution of the head crest in the rock pigeon.";
RL Science 339:1063-1067(2013).
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PKK22436.1}.
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DR EMBL; AKCR02000062; PKK22436.1; -; Genomic_DNA.
DR RefSeq; XP_013222882.1; XM_013367428.1.
DR GeneID; 102090468; -.
DR CTD; 4052; -.
DR OrthoDB; 354414at2759; -.
DR Proteomes; UP000053872; Unassembled WGS sequence.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 11.
DR Gene3D; 2.10.25.10; Laminin; 16.
DR Gene3D; 3.90.290.10; TGF-beta binding (TB) domain; 4.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR017878; TB_dom.
DR InterPro; IPR036773; TB_dom_sf.
DR PANTHER; PTHR24034; EGF-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24034:SF166; VACUOLAR-SORTING RECEPTOR 1; 1.
DR Pfam; PF07645; EGF_CA; 14.
DR Pfam; PF00683; TB; 4.
DR SMART; SM00181; EGF; 16.
DR SMART; SM00179; EGF_CA; 15.
DR SUPFAM; SSF57196; EGF/Laminin; 5.
DR SUPFAM; SSF57184; Growth factor receptor domain; 4.
DR SUPFAM; SSF57581; TB module/8-cys domain; 4.
DR PROSITE; PS00010; ASX_HYDROXYL; 10.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS01186; EGF_2; 9.
DR PROSITE; PS50026; EGF_3; 8.
DR PROSITE; PS01187; EGF_CA; 7.
DR PROSITE; PS51364; TB; 4.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000053872};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022530};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..1353
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014183560"
FT DOMAIN 73..105
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 232..277
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 301..341
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 352..404
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 715..755
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 756..796
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 797..837
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 838..879
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 880..921
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 983..1037
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 1160..1213
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 1298..1342
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 179..198
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 432..456
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 77..87
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 95..104
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 1353 AA; 148668 MW; 76B4372E35FD50AD CRC64;
MDTKVICLFF FFSLPPLTVG NHTGRIKVVF TPSICKVTCT KGNCQNNCEK GNTTTLISEN
GHAADTLTAT NFRVVICHLP CMNGGQCSSR DKCQCPPNYT GKLCQIPVQT ANTPKLYHQP
QQVNKAVGSQ IIHSTHTLPL TMSGQQGVKV KFPPNIVNIH VKHPPEASVQ IHQVSRIDST
STGQKAKVPQ PGHPQVSYQG LPYQKTQKGH TTYTNQQPIP HMFPVSVKTQ LGRCFQETIG
TQCGKALPGL SKQEDCCGTV GTSWGFNKCQ KCPKKPSYHG YSPMMECPQG YKRINATFCQ
DINECQLQGV CPNGECLNTM GSYRCTCKMG FVPDPTLSRC IPDNPVVAEE KGPCYRFVSA
GKQCMHPLSV QLSKQLCCCS VGKAWGPHCE KCPLPGTAAF KEICPGGMGY TVSGPHRNKL
YHHPAVRVQP PVIGKTPITQ PVAKGTSPPP LPAKEEPVEA LTFSQKSETE MAVQEVATAA
PDQELASLDQ EKQPDLEPGQ PQLSPGISTI NLHPQFPVIE KTSPPLPVEV APEVSTSSAS
QVIAPTQVTE INECTVNPDI CGAGHCVNLP VGYTCICYEG YRLNDQQTKC SDINECIQAP
HLCSLGRCEN TEGSFLCICQ AGFMASEDGT DCVDFDECSR PHICGEGFCI NTLGSYRCEY
CDSGYQMNRR GECEDIDECL TPTTCPDAQC INAPGSYQCI PCRVGFRGWN GQCRDIDECQ
YGNLCTNGRC ENVEGSFRCI CGQGFKLSAS EDQCEDIDEC QQRSLCTNGR CRNTEGSFRC
ICSQGYALSA TGDQCEDVDE CLQDSDICRG GSCINTDGSY KCTCPDGFQQ IANRGCQDIN
ECERSDLCSP HGECLNTDGS YQCICERGFS VSADGRTCED VDECENGTIC GSHGFCENMD
GSYRCLCYQG YQDAQDGQGC TDVNECEMLS GVCGEALCEN VDGSFLCLCS DENQEYDPMT
GQCRFRTSPE LPIEADEHED GKKECYYNLN DANFCDNVLT SNVTKQECCC TLGAGWGDNC
EIFPCPVFGT AEFTDLCPEG KGFIPSGESS YGLPAQNYKD ADECQLFGQE ICKNGFCLNT
QPGYECYCKQ GTYYDPVKLQ CFDTDECQDP NSCIDGQCIN TEGSYNCFCT HPMVLDATEK
RCIRPADSSE QTEETEVYQD LCWQHLSDDF VCSRPLVGKQ TTYTECCCLY GEAWGMQCAL
CPMKESEDYA QLCNIPVPGS RRPYGQDALV DFEEHYTPET NPYFVEDRFL NSFEELQAEE
CGILNGCENG RCVRVQEGYT CDCFDGYHLD MAKMTCVDVN ECNELNNRMS LCKNAKCINT
EGSYKCLCLP GYVPSDKPNY CTPLNSELDS ELE
//
